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    WDFY2 WD repeat and FYVE domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 115825, updated on 5-Aug-2018
    Official Symbol
    WDFY2provided by HGNC
    Official Full Name
    WD repeat and FYVE domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:20482
    See related
    Ensembl:ENSG00000139668 MIM:610418; Vega:OTTHUMG00000017407
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PROF; WDF2; ZFYVE22
    Summary
    This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in skin (RPKM 5.8), bone marrow (RPKM 4.0) and 25 other tissues See more
    Orthologs
    See WDFY2 in Genome Data Viewer
    Location:
    13q14.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (51584194..51766799)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (52158484..52340935)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene microRNA 4703 Neighboring gene RNA, U6 small nuclear 65, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 413, pseudogene Neighboring gene RNA, Ro-associated Y1 pseudogene 6 Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene 1 Neighboring gene dehydrogenase/reductase 12 Neighboring gene uncharacterized LOC107984561 Neighboring gene transmembrane protein 272

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
      Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
    • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
      Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    WD repeat and FYVE domain-containing protein 2
    Names
    WD40 and FYVE domain containing 2
    WD40- and FYVE domain-containing protein 2
    propeller-FYVE protein
    zinc finger FYVE domain-containing protein 22

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052950.3NP_443182.1  WD repeat and FYVE domain-containing protein 2

      See identical proteins and their annotated locations for NP_443182.1

      Status: REVIEWED

      Source sequence(s)
      AL136525, BC014004, DA124107
      Consensus CDS
      CCDS9429.1
      UniProtKB/Swiss-Prot
      Q96P53
      Related
      ENSP00000298125.4, OTTHUMP00000018795, ENST00000298125.6, OTTHUMT00000045985
      Conserved Domains (3) summary
      cd15718
      Location:279348
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:159197
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:16272
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      51584194..51766799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449316.1XP_024305084.1  WD repeat and FYVE domain-containing protein 2 isoform X2

      Conserved Domains (4) summary
      smart00320
      Location:292328
      WD40; WD40 repeats
      cd15718
      Location:213282
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:93131
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:2210
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_017020386.1XP_016875875.1  WD repeat and FYVE domain-containing protein 2 isoform X3

      Conserved Domains (5) summary
      smart00320
      Location:269305
      WD40; WD40 repeats
      COG2319
      Location:13305
      WD40; WD40 repeat [General function prediction only]
      cd15718
      Location:190259
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:70108
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:11183
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_011534915.2XP_011533217.1  WD repeat and FYVE domain-containing protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011533217.1

      Conserved Domains (5) summary
      smart00320
      Location:269305
      WD40; WD40 repeats
      COG2319
      Location:13305
      WD40; WD40 repeat [General function prediction only]
      cd15718
      Location:190259
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:70108
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:11183
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_011534914.1XP_011533216.1  WD repeat and FYVE domain-containing protein 2 isoform X1

      Conserved Domains (4) summary
      COG2319
      Location:18272
      WD40; WD40 repeat [General function prediction only]
      cd15718
      Location:279348
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:202239
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:16272
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_024449317.1XP_024305085.1  WD repeat and FYVE domain-containing protein 2 isoform X2

      Conserved Domains (4) summary
      smart00320
      Location:292328
      WD40; WD40 repeats
      cd15718
      Location:213282
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:93131
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:2210
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_941484.2 RNA Sequence

    2. XR_941485.2 RNA Sequence

    3. XR_941483.1 RNA Sequence

    4. XR_001749475.1 RNA Sequence

    5. XR_941489.1 RNA Sequence

    6. XR_941487.1 RNA Sequence

    7. XR_941488.1 RNA Sequence

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