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    WDFY2 WD repeat and FYVE domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 115825, updated on 5-Aug-2022

    Summary

    Official Symbol
    WDFY2provided by HGNC
    Official Full Name
    WD repeat and FYVE domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:20482
    See related
    Ensembl:ENSG00000139668 MIM:610418; AllianceGenome:HGNC:20482
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PROF; WDF2; ZFYVE22
    Summary
    This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in skin (RPKM 5.8), bone marrow (RPKM 4.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See WDFY2 in Genome Data Viewer
    Location:
    13q14.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (51584462..51767709)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (50799394..50982622)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (52158598..52341845)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene microRNA 4703 Neighboring gene RNA, U6 small nuclear 65, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 413, pseudogene Neighboring gene RNY1 pseudogene 6 Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene 1 Neighboring gene uncharacterized LOC124903177 Neighboring gene dehydrogenase/reductase 12 Neighboring gene uncharacterized LOC107984561 Neighboring gene transmembrane protein 272 Neighboring gene coiled-coil domain containing 70

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WD repeat and FYVE domain-containing protein 2
    Names
    WD40 and FYVE domain containing 2
    WD40- and FYVE domain-containing protein 2
    propeller-FYVE protein
    zinc finger FYVE domain-containing protein 22

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052950.4NP_443182.1  WD repeat and FYVE domain-containing protein 2

      See identical proteins and their annotated locations for NP_443182.1

      Status: REVIEWED

      Source sequence(s)
      AL136525, BC014004, DA124107
      Consensus CDS
      CCDS9429.1
      UniProtKB/Swiss-Prot
      Q96CS1, Q96P53
      Related
      ENSP00000298125.4, ENST00000298125.7
      Conserved Domains (3) summary
      cd15718
      Location:279348
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:159197
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:16272
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      51584462..51767709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534915.3XP_011533217.1  WD repeat and FYVE domain-containing protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011533217.1

      Conserved Domains (5) summary
      smart00320
      Location:269305
      WD40; WD40 repeats
      COG2319
      Location:13305
      WD40; WD40 repeat [General function prediction only]
      cd15718
      Location:190259
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:70108
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:11183
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_011534914.2XP_011533216.1  WD repeat and FYVE domain-containing protein 2 isoform X1

      Conserved Domains (4) summary
      COG2319
      Location:18272
      WD40; WD40 repeat [General function prediction only]
      cd15718
      Location:279348
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:202239
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:16272
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_047430089.1XP_047286045.1  WD repeat and FYVE domain-containing protein 2 isoform X4

    4. XM_024449317.2XP_024305085.1  WD repeat and FYVE domain-containing protein 2 isoform X2

      Conserved Domains (3) summary
      cd15718
      Location:213282
      FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
      sd00039
      Location:93131
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:2210
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_047430088.1XP_047286044.1  WD repeat and FYVE domain-containing protein 2 isoform X3

    6. XM_047430091.1XP_047286047.1  WD repeat and FYVE domain-containing protein 2 isoform X5

    RNA

    1. XR_007063659.1 RNA Sequence

    2. XR_941483.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      50799394..50982622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)