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    ARL11 ADP ribosylation factor like GTPase 11 [ Homo sapiens (human) ]

    Gene ID: 115761, updated on 17-Jun-2019

    Summary

    Official Symbol
    ARL11provided by HGNC
    Official Full Name
    ADP ribosylation factor like GTPase 11provided by HGNC
    Primary source
    HGNC:HGNC:24046
    See related
    Ensembl:ENSG00000152213 MIM:609351
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARLTS1
    Summary
    This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]
    Expression
    Broad expression in lymph node (RPKM 2.7), spleen (RPKM 2.1) and 17 other tissues See more
    Orthologs

    Genomic context

    See ARL11 in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (49628456..49633872)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (50202435..50208008)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RCC1 and BTB domain containing protein 1 Neighboring gene uncharacterized LOC105370204 Neighboring gene uncharacterized LOC105370205 Neighboring gene EBP like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ33930, MGC17429

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ADP-ribosylation factor-like protein 11
    Names
    ADP-ribosylation factor-like 11
    ADP-ribosylation factor-like tumor suppressor gene 1
    ADP-ribosylation factor-like tumor suppressor protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021342.1 RefSeqGene

      Range
      5001..10574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138450.6NP_612459.1  ADP-ribosylation factor-like protein 11

      See identical proteins and their annotated locations for NP_612459.1

      Status: REVIEWED

      Source sequence(s)
      AF441378, AK091249
      Consensus CDS
      CCDS9419.1
      UniProtKB/Swiss-Prot
      Q969Q4
      Related
      ENSP00000282026.1, ENST00000282026.1
      Conserved Domains (1) summary
      cd04156
      Location:14172
      ARLTS1; Arf-like tumor suppressor gene 1 (ARLTS1 or Arl11)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      49628456..49633872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266253.3XP_005266310.1  ADP-ribosylation factor-like protein 11 isoform X1

      See identical proteins and their annotated locations for XP_005266310.1

      UniProtKB/Swiss-Prot
      Q969Q4
      Conserved Domains (1) summary
      cd04156
      Location:14172
      ARLTS1; Arf-like tumor suppressor gene 1 (ARLTS1 or Arl11)
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