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    ARHGAP33 Rho GTPase activating protein 33 [ Homo sapiens (human) ]

    Gene ID: 115703, updated on 23-May-2018
    Official Symbol
    ARHGAP33provided by HGNC
    Official Full Name
    Rho GTPase activating protein 33provided by HGNC
    Primary source
    HGNC:HGNC:23085
    See related
    Ensembl:ENSG00000004777 MIM:614902; Vega:OTTHUMG00000182071
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SNX26; TCGAP; NOMA-GAP
    Summary
    This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
    Expression
    Broad expression in testis (RPKM 7.3), brain (RPKM 5.7) and 23 other tissues See more
    Orthologs
    See ARHGAP33 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (35775515..35788822)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36266417..36279724)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene heat shock protein family B (small) member 6 Neighboring gene proline and serine rich 3 Neighboring gene long intergenic non-protein coding RNA 1529 Neighboring gene proline dehydrogenase 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ39019

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activator activity TAS
    Traceable Author Statement
    more info
     
    phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    rho GTPase-activating protein 33
    Names
    neurite outgrowth multiadaptor RhoGAP protein
    rho-type GTPase-activating protein 33
    sorting nexin 26
    tc10/CDC42 GTPase-activating protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172630.1NP_001166101.1  rho GTPase-activating protein 33 isoform 2

      See identical proteins and their annotated locations for NP_001166101.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in 5' and 3' coding regions, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, has a bigger additional segment and also lacks a smaller segment in the C-terminal region, as compared to isoform 1.
      Source sequence(s)
      AK127255, BC014084
      Consensus CDS
      CCDS54254.1
      UniProtKB/Swiss-Prot
      O14559
      Related
      ENSP00000368227.5, OTTHUMP00000268281, ENST00000378944.9, OTTHUMT00000459118
      Conserved Domains (3) summary
      cd11835
      Location:54107
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:175369
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:132
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    2. NM_052948.3NP_443180.2  rho GTPase-activating protein 33 isoform 1

      See identical proteins and their annotated locations for NP_443180.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK096338, AK127255, AL137579, BC014084, BC128586
      Consensus CDS
      CCDS12477.1
      UniProtKB/Swiss-Prot
      O14559
      UniProtKB/TrEMBL
      A1A5D2
      Related
      ENSP00000320038.4, OTTHUMP00000268283, ENST00000314737.9, OTTHUMT00000459120
      Conserved Domains (3) summary
      cd07299
      Location:56168
      PX_TCGAP; The phosphoinositide binding Phox Homology domain of Tc10/Cdc42 GTPase-activating protein
      cd11835
      Location:190243
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:311505
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      35775515..35788822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526420.1XP_011524722.1  rho GTPase-activating protein 33 isoform X7

      Conserved Domains (3) summary
      cd11835
      Location:54107
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:176370
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:132
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    2. XM_006722999.2XP_006723062.1  rho GTPase-activating protein 33 isoform X4

      Conserved Domains (3) summary
      cd11835
      Location:190243
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:312506
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:56168
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    3. XM_005258488.2XP_005258545.1  rho GTPase-activating protein 33 isoform X6

      See identical proteins and their annotated locations for XP_005258545.1

      UniProtKB/Swiss-Prot
      O14559
      Conserved Domains (3) summary
      cd11835
      Location:190243
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:311505
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:56168
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    4. XM_017026238.1XP_016881727.1  rho GTPase-activating protein 33 isoform X9

    5. XM_011526421.2XP_011524723.1  rho GTPase-activating protein 33 isoform X10

      Conserved Domains (3) summary
      cd11835
      Location:227280
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:349543
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:93205
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    6. XM_011526418.1XP_011524720.1  rho GTPase-activating protein 33 isoform X3

      Conserved Domains (3) summary
      cd11835
      Location:54107
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:176370
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:132
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    7. XM_011526417.1XP_011524719.1  rho GTPase-activating protein 33 isoform X2

      Conserved Domains (3) summary
      cd11835
      Location:54107
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:176370
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:132
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    8. XM_011526416.1XP_011524718.1  rho GTPase-activating protein 33 isoform X1

      Conserved Domains (3) summary
      cd11835
      Location:54107
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:175369
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:132
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    9. XM_011526419.1XP_011524721.1  rho GTPase-activating protein 33 isoform X5

      See identical proteins and their annotated locations for XP_011524721.1

      UniProtKB/Swiss-Prot
      O14559
      Conserved Domains (3) summary
      cd11835
      Location:54107
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:175369
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
      cl02563
      Location:132
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    10. XM_006723003.2XP_006723066.1  rho GTPase-activating protein 33 isoform X8

      Conserved Domains (1) summary
      PHA03247
      Location:455757
      PHA03247; large tegument protein UL36; Provisional

    RNA

    1. XR_002958249.1 RNA Sequence

    2. XR_935731.2 RNA Sequence

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