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    CKB creatine kinase B [ Homo sapiens (human) ]

    Gene ID: 1152, updated on 15-Apr-2019

    Summary

    Official Symbol
    CKBprovided by HGNC
    Official Full Name
    creatine kinase Bprovided by HGNC
    Primary source
    HGNC:HGNC:1991
    See related
    Ensembl:ENSG00000166165 MIM:123280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCK; B-CK; CKBB; CPK-B; HEL-211; HEL-S-29
    Summary
    The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in colon (RPKM 268.3), prostate (RPKM 227.9) and 18 other tissues See more
    Orthologs

    Genomic context

    See CKB in Genome Data Viewer
    Location:
    14q32.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (103519658..103522859, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103985995..103989196, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene microtubule affinity regulating kinase 3 Neighboring gene ribosomal protein L10a pseudogene 1 Neighboring gene uncharacterized LOC112268130 Neighboring gene tRNA methyltransferase 61A Neighboring gene RNA, U7 small nuclear 160 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    creatine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular chloride ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cerebellum development IEA
    Inferred from Electronic Annotation
    more info
     
    creatine metabolic process TAS
    Traceable Author Statement
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    substantia nigra development HEP PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    creatine kinase B-type
    Names
    brain creatine kinase
    creatine kinase B chain
    creatine kinase brain
    creatine kinase brain-type
    creatine phosphokinase B-type
    epididymis luminal protein 211
    epididymis secretory protein Li 29
    NP_001814.2
    XP_016876440.1
    XP_016876441.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362531.1NP_001349460.1  creatine kinase B-type isoform 2

      Status: REVIEWED

      Source sequence(s)
      BM684665, BP213119, KU177978
      Conserved Domains (1) summary
      cd00716
      Location:16397
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes
    2. NM_001823.5NP_001814.2  creatine kinase B-type isoform 1

      See identical proteins and their annotated locations for NP_001814.2

      Status: REVIEWED

      Source sequence(s)
      AK312282, BM684665, BP213119
      Consensus CDS
      CCDS9981.1
      UniProtKB/Swiss-Prot
      P12277
      UniProtKB/TrEMBL
      V9HWH2
      Related
      ENSP00000299198.2, ENST00000348956.7
      Conserved Domains (1) summary
      cd00716
      Location:16373
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

      Range
      103519658..103522859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020951.1XP_016876440.1  creatine kinase B-type isoform X1

      UniProtKB/TrEMBL
      A0A0S2Z471
      Conserved Domains (1) summary
      cd00716
      Location:16397
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes
    2. XM_017020952.1XP_016876441.1  creatine kinase B-type isoform X2

      UniProtKB/TrEMBL
      G3V4N7
      Related
      ENSP00000451904.1, ENST00000553878.5
      Conserved Domains (1) summary
      cl02823
      Location:16217
      phosphagen_kinases; Phosphagen (guanidino) kinases
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