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    CYGB cytoglobin [ Homo sapiens (human) ]

    Gene ID: 114757, updated on 11-Nov-2018

    Summary

    Official Symbol
    CYGBprovided by HGNC
    Official Full Name
    cytoglobinprovided by HGNC
    Primary source
    HGNC:HGNC:16505
    See related
    Ensembl:ENSG00000161544 MIM:608759; Vega:OTTHUMG00000180289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HGB; STAP
    Summary
    This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in fat (RPKM 16.5), urinary bladder (RPKM 7.0) and 23 other tissues See more
    Orthologs

    Genomic context

    See CYGB in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (76527348..76557692, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74523430..74533987, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene aralkylamine N-acetyltransferase Neighboring gene rhomboid 5 homolog 2 Neighboring gene photoreceptor disc component Neighboring gene small nucleolar RNA, C/D box 1C Neighboring gene small nucleolar RNA host gene 16 Neighboring gene small nucleolar RNA, C/D box 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of nitric oxide, organism-specific biosystem (from REACTOME)
      Metabolism of nitric oxide, organism-specific biosystemNitric oxide (NO), a multifunctional second messenger, is implicated in physiological functions in mammals that range from immune response and potentiation of synaptic transmission to dilation of blo...
    • eNOS activation, organism-specific biosystem (from REACTOME)
      eNOS activation, organism-specific biosystemeNOS activity is regulated by numerous post-translational modifications including phosphorylation and acylation, which also modulate its interactions with other proteins and its subcellular localizat...
    • eNOS activation and regulation, organism-specific biosystem (from REACTOME)
      eNOS activation and regulation, organism-specific biosystemOriginally identified as endothelium-derived relaxing factor, eNOS derived NO is a critical signaling molecule in vascular homeostasis. It regulates blood pressure and vascular tone, and is involved...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    catalase activity IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nitric oxide dioxygenase activity TAS
    Traceable Author Statement
    more info
     
    oxygen binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxygen carrier activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of collagen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hepatic stellate cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    oxygen transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    oxygen transport TAS
    Traceable Author Statement
    more info
     
    regulation of nitric-oxide synthase activity TAS
    Traceable Author Statement
    more info
     
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear speck IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    cytoglobin
    Names
    histoglobin
    stellate cell activation-associated protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134268.4NP_599030.1  cytoglobin

      See identical proteins and their annotated locations for NP_599030.1

      Status: VALIDATED

      Source sequence(s)
      AI470692, AK098057, BQ881744
      Consensus CDS
      CCDS11746.1
      UniProtKB/Swiss-Prot
      Q8WWM9
      UniProtKB/TrEMBL
      A0A1K0FUB6
      Related
      ENSP00000293230.4, OTTHUMP00000263836, ENST00000293230.9, OTTHUMT00000450590
      Conserved Domains (1) summary
      cd08924
      Location:22171
      Cygb; Cytoglobin and related globins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      76527348..76557692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024116.1XP_016879605.1  cytoglobin isoform X2

      Conserved Domains (1) summary
      cl21461
      Location:1106
      Globin_like; Globin-like proteins
    2. XM_005257005.3XP_005257062.1  cytoglobin isoform X1

      Conserved Domains (1) summary
      cd08924
      Location:22171
      Cygb; Cytoglobin and related globins
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