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    Ncf1 neutrophil cytosolic factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114553, updated on 2-Oct-2018

    Summary

    Official Symbol
    Ncf1provided by RGD
    Official Full Name
    neutrophil cytosolic factor 1provided by RGD
    Primary source
    RGD:61307
    See related
    Ensembl:ENSRNOG00000001480 Vega:OTTRNOG00000000213
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ncf-1; p47phox
    Summary
    involved in the regulation of arthritis severity in rats [RGD, Feb 2006]
    Expression
    Biased expression in Heart (RPKM 326.4), Spleen (RPKM 228.0) and 8 other tissues See more
    Orthologs

    Genomic context

    See Ncf1 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (25497104..25506300)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (27505793..27514989)

    Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352437 Neighboring gene general transcription factor II I Neighboring gene uncharacterized LOC103691302 Neighboring gene GTF2I repeat domain containing 2 Neighboring gene RCC1 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3,4-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    superoxide-generating NADPH oxidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to superoxide-generating NADPH oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    superoxide-generating NADPH oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    superoxide-generating NADPH oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to superoxide-generating NADPH oxidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular defense response ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to fungus ISO
    Inferred from Sequence Orthology
    more info
     
    hydrogen peroxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    leukotriene metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    neutrophil mediated killing of fungus ISO
    Inferred from Sequence Orthology
    more info
     
    neutrophil mediated killing of gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epidermal growth factor-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    respiratory burst IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    respiratory burst IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    respiratory burst ISO
    Inferred from Sequence Orthology
    more info
     
    respiratory burst involved in defense response ISO
    Inferred from Sequence Orthology
    more info
     
    response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    response to yeast ISO
    Inferred from Sequence Orthology
    more info
     
    superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
     
    superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    superoxide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NADPH oxidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NADPH oxidase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NADPH oxidase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    neutrophil cytosolic factor 1
    Names
    neutrophil cytosol factor 1
    phagocyte oxidase 47 kDa

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053734.2NP_446186.2  neutrophil cytosolic factor 1

      See identical proteins and their annotated locations for NP_446186.2

      Status: PROVISIONAL

      Source sequence(s)
      BC061810
      UniProtKB/TrEMBL
      Q811Y3
      Related
      ENSRNOP00000002028.5, OTTRNOP00000000154, ENSRNOT00000002028.8, OTTRNOT00000000305
      Conserved Domains (5) summary
      cd06887
      Location:6123
      PX_p47phox; The phosphoinositide binding Phox Homology domain of the p47phox subunit of NADPH oxidase
      cd12021
      Location:160212
      SH3_p47phox_1; First or N-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1
      cd12022
      Location:230282
      SH3_p47phox_2; Second or C-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1
      pfam08944
      Location:332388
      p47_phox_C; NADPH oxidase subunit p47Phox, C terminal domain
      pfam16621
      Location:282331
      NECFESHC; SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

      Range
      25497104..25506300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000080.1 Alternate Rn_Celera

      Range
      24246402..24255599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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