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    Ncf1 neutrophil cytosolic factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114553, updated on 30-Sep-2021

    Summary

    Symbol
    Ncf1provided by RGD
    Full Name
    neutrophil cytosolic factor 1provided by RGD
    Primary source
    RGD:61307
    See related
    EnsemblRapid:ENSRNOG00000001480
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ncf-1; p47phox
    Summary
    involved in the regulation of arthritis severity in rats [RGD, Feb 2006]
    Expression
    Biased expression in Heart (RPKM 326.4), Spleen (RPKM 228.0) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ncf1 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (22485382..22494647)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (25497104..25506300)

    Chromosome 12 - NC_051347.1Genomic Context describing neighboring genes Neighboring gene GTF2I repeat domain containing 1 Neighboring gene general transcription factor II I Neighboring gene uncharacterized LOC103691302 Neighboring gene GTF2I repeat domain containing 2 Neighboring gene RCC1 like Neighboring gene cytosolic arginine sensor for mTORC1 subunit 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular defense response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to fungus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hydrogen peroxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within leukocyte mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within leukotriene metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neutrophil-mediated killing of fungus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neutrophil-mediated killing of gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reactive oxygen species biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of respiratory burst involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in respiratory burst IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in respiratory burst IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within respiratory burst ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within respiratory burst involved in defense response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to yeast ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in superoxide anion generation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within_positive_effect superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of NADPH oxidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of NADPH oxidase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of NADPH oxidase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    neutrophil cytosolic factor 1
    Names
    neutrophil cytosol factor 1
    neutrophil cytosol factor 1-like
    phagocyte oxidase 47 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053734.2NP_446186.2  neutrophil cytosolic factor 1

      See identical proteins and their annotated locations for NP_446186.2

      Status: PROVISIONAL

      Source sequence(s)
      BC061810
      UniProtKB/TrEMBL
      Q811Y3
      Related
      ENSRNOP00000002028.5, ENSRNOT00000002028.9
      Conserved Domains (5) summary
      cd06887
      Location:6123
      PX_p47phox; The phosphoinositide binding Phox Homology domain of the p47phox subunit of NADPH oxidase
      cd12021
      Location:160212
      SH3_p47phox_1; First or N-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1
      cd12022
      Location:230282
      SH3_p47phox_2; Second or C-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1
      pfam08944
      Location:332388
      p47_phox_C; NADPH oxidase subunit p47Phox, C terminal domain
      pfam16621
      Location:282331
      NECFESHC; SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051347.1 Reference mRatBN7.2 Primary Assembly

      Range
      22485382..22494647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089020.1XP_038944948.1  neutrophil cytosolic factor 1 isoform X1

      Conserved Domains (5) summary
      cd06887
      Location:6123
      PX_p47phox; The phosphoinositide binding Phox Homology domain of the p47phox subunit of NADPH oxidase
      cd12022
      Location:189241
      SH3_p47phox_2; Second or C-terminal Src homology 3 domain of the p47phox subunit of NADPH oxidase, also called Neutrophil Cytosolic Factor 1
      pfam08944
      Location:317348
      p47_phox_C; NADPH oxidase subunit p47Phox, C terminal domain
      pfam16621
      Location:241290
      NECFESHC; SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
      cl17036
      Location:151171
      SH3; Src Homology 3 domain superfamily
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