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    CDC37 cell division cycle 37 [ Homo sapiens (human) ]

    Gene ID: 11140, updated on 7-Jul-2019

    Summary

    Official Symbol
    CDC37provided by HGNC
    Official Full Name
    cell division cycle 37provided by HGNC
    Primary source
    HGNC:HGNC:1735
    See related
    Ensembl:ENSG00000105401 MIM:605065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P50CDC37
    Summary
    The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 70.6), spleen (RPKM 61.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See CDC37 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10391128..10403568, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10501809..10514271, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene intercellular adhesion molecule 3 Neighboring gene tyrosine kinase 2 Neighboring gene microRNA 1181 Neighboring gene phosphodiesterase 4A Neighboring gene kelch like ECH associated protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Aryl Hydrocarbon Receptor, organism-specific biosystem (from WikiPathways)
      Aryl Hydrocarbon Receptor, organism-specific biosystemThe Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression. The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or...
    • Aryl Hydrocarbon Receptor Pathway, organism-specific biosystem (from WikiPathways)
      Aryl Hydrocarbon Receptor Pathway, organism-specific biosystemThe aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic m...
    • Constitutive Signaling by EGFRvIII, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by EGFRvIII, organism-specific biosystemIn glioblastoma, the most prevalent EGFR mutation, present in ~25% of tumors, is the deletion of the ligand binding domain of EGFR, accompanied with amplification of the mutated allele, which results...
    • Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, organism-specific biosystemSignaling by EGFR is frequently activated in cancer through activating mutations in the coding sequence of the EGFR gene, resulting in expression of a constitutively active mutant protein. Epidermal ...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • Downregulation of ERBB2 signaling, organism-specific biosystem (from REACTOME)
      Downregulation of ERBB2 signaling, organism-specific biosystemSignaling by ERBB2 can be downregulated by ubiquitination and subsequent proteasome-dependent degradation of ERBB2 or activated ERBB2 heterodimers. In addition, protein tyrosine phosphatases that dep...
    • LKB1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      LKB1 signaling events, organism-specific biosystem
      LKB1 signaling events
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows signaling by constitutively active EGFR cancer variants in the context of "Signaling by EGFR", allowing users to compare cancer events with the wild-ty...
    • Signaling by EGFRvIII in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFRvIII in Cancer, organism-specific biosystemEGFRvIII (EGFR V30_R297delinsG) is the most prevalent EGFR variant in glioblastoma, but it is also found in other cancer types. In-frame deletion of the ligand binding domain in EGFRvIII is frequentl...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by Ligand-Responsive EGFR Variants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by Ligand-Responsive EGFR Variants in Cancer, organism-specific biosystemLigand-responsive EGFR cancer variants harbor mutations in the kinase domain or point mutations in the extracellular domain. These altered EGFR proteins are able to signal in the absence of ligands, ...
    • Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystem (from WikiPathways)
      Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystemThis pathway Involved in chemo-resistance of cells in bladder cancer begins with LOXL2 activation of CDC37 and COL2A1. COL2A1 activates the complex NRF1/2 and two other complexes that trigger RTK/MAP...
    • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    ERBB2 signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of mitophagy in response to mitochondrial depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    posttranscriptional regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein targeting TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cyclin-dependent protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of interferon-gamma-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    HSP90-CDC37 chaperone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperone complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    hsp90 co-chaperone Cdc37
    Names
    CDC37 (cell division cycle 37, S. cerevisiae, homolog)
    CDC37 cell division cycle 37 homolog
    cell division cycle 37 homolog
    hsp90 chaperone protein kinase-targeting subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007065.4NP_008996.1  hsp90 co-chaperone Cdc37

      See identical proteins and their annotated locations for NP_008996.1

      Status: REVIEWED

      Source sequence(s)
      BC000083, BE796008
      Consensus CDS
      CCDS12237.1
      UniProtKB/Swiss-Prot
      Q16543
      UniProtKB/TrEMBL
      A0A024R7B7
      Related
      ENSP00000222005.1, ENST00000222005.7
      Conserved Domains (3) summary
      smart01071
      Location:1127
      CDC37_N; Cdc37 N terminal kinase binding
      smart01069
      Location:287377
      CDC37_C; Cdc37 C terminal domain
      smart01070
      Location:133275
      CDC37_M; Cdc37 Hsp90 binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      10391128..10403568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527652.3XP_011525954.1  hsp90 co-chaperone Cdc37 isoform X1

      Related
      ENSP00000465724.1, ENST00000593124.1
      Conserved Domains (3) summary
      smart01071
      Location:1126
      CDC37_N; Cdc37 N terminal kinase binding
      smart01069
      Location:338428
      CDC37_C; Cdc37 C terminal domain
      smart01070
      Location:184326
      CDC37_M; Cdc37 Hsp90 binding domain
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