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    CD160 CD160 molecule [ Homo sapiens (human) ]

    Gene ID: 11126, updated on 8-Jul-2021

    Summary

    Official Symbol
    CD160provided by HGNC
    Official Full Name
    CD160 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:17013
    See related
    Ensembl:ENSG00000117281 MIM:604463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NK1; BY55; NK28
    Summary
    CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in spleen (RPKM 5.2), duodenum (RPKM 1.7) and 12 other tissues See more
    Orthologs
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    Genomic context

    See CD160 in Genome Data Viewer
    Location:
    1q21.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (145719312..145739288)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145695798..145715586, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NBPF member 25, pseudogene Neighboring gene G protein-coupled receptor 89A Neighboring gene PDZ domain containing 1 Neighboring gene ring finger protein 115 Neighboring gene RNA polymerase III subunit C Neighboring gene nudix hydrolase 17 Neighboring gene protein inhibitor of activated STAT 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ46513

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MHC class I protein complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MHC class I receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables MHC class Ib receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables activating MHC class I receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mucosal immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of CD4-positive, alpha-beta T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of adaptive immune memory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of endothelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of natural killer cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of natural killer cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of natural killer cell mediated immune response to tumor cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in anchored component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in anchored component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    CD160 antigen
    Names
    CD160-delta Ig
    natural killer cell receptor BY55
    natural killer cell receptor, immunoglobulin superfamily member

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007053.4NP_008984.1  CD160 antigen precursor

      See identical proteins and their annotated locations for NP_008984.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AA463248, AC242845, BC014465, CD638675
      Consensus CDS
      CCDS72861.1
      UniProtKB/Swiss-Prot
      O95971
      UniProtKB/TrEMBL
      Q6FH89
      Related
      ENSP00000358294.1, ENST00000369288.7

    RNA

    1. NR_103845.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AA463248, AC242845, BC014465, CD638675

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      145719312..145739288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509104.2XP_011507406.1  CD160 antigen isoform X1

      See identical proteins and their annotated locations for XP_011507406.1

      UniProtKB/TrEMBL
      B8PRF2
    2. XM_005272929.3XP_005272986.1  CD160 antigen isoform X1

      See identical proteins and their annotated locations for XP_005272986.1

      UniProtKB/TrEMBL
      B8PRF2
      Related
      ENSP00000385199.4, ENST00000401557.7
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