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    ESM1 endothelial cell specific molecule 1 [ Homo sapiens (human) ]

    Gene ID: 11082, updated on 12-Mar-2019

    Summary

    Official Symbol
    ESM1provided by HGNC
    Official Full Name
    endothelial cell specific molecule 1provided by HGNC
    Primary source
    HGNC:HGNC:3466
    See related
    Ensembl:ENSG00000164283 MIM:601521
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    endocan
    Summary
    This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
    Expression
    Biased expression in thyroid (RPKM 12.6), kidney (RPKM 8.9) and 9 other tissues See more
    Orthologs

    Genomic context

    See ESM1 in Genome Data Viewer
    Location:
    5q11.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (54977867..54985586, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54273695..54281414, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene chondroitin sulfate proteoglycan 4-like Neighboring gene zinc finger protein 561-like Neighboring gene thiosulfate sulfurtransferase like domain containing 1 pseudogene Neighboring gene uncharacterized LOC102467081 Neighboring gene granzyme K

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of endothelial cell-specific molecule 1 (ESM1) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Gastric Cancer Network 1, organism-specific biosystem (from WikiPathways)
      Gastric Cancer Network 1, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Networks generated by Ingenuity Pathway Analysis.

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hepatocyte growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hepatocyte growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    angiogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of hepatocyte growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of hepatocyte growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    endothelial cell-specific molecule 1
    Names
    ESM-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135604.1NP_001129076.1  endothelial cell-specific molecule 1 isoform b precursor

      See identical proteins and their annotated locations for NP_001129076.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC010436, AK300634
      Consensus CDS
      CCDS47206.1
      UniProtKB/Swiss-Prot
      Q9NQ30
      Related
      ENSP00000370810.4, ENST00000381403.4
      Conserved Domains (1) summary
      smart00121
      Location:26100
      IB; Insulin growth factor-binding protein homologues
    2. NM_007036.5NP_008967.1  endothelial cell-specific molecule 1 isoform a precursor

      See identical proteins and their annotated locations for NP_008967.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC010436, AC034238, AK311817
      Consensus CDS
      CCDS3963.1
      UniProtKB/Swiss-Prot
      Q9NQ30
      Related
      ENSP00000370812.4, ENST00000381405.4
      Conserved Domains (1) summary
      smart00121
      Location:26100
      IB; Insulin growth factor-binding protein homologues

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

      Range
      54977867..54985586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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