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    DSTN destrin, actin depolymerizing factor [ Homo sapiens (human) ]

    Gene ID: 11034, updated on 5-Sep-2021

    Summary

    Official Symbol
    DSTNprovided by HGNC
    Official Full Name
    destrin, actin depolymerizing factorprovided by HGNC
    Primary source
    HGNC:HGNC:15750
    See related
    Ensembl:ENSG00000125868 MIM:609114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADF; ACTDP; HEL32; bA462D18.2
    Summary
    The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 293.6), esophagus (RPKM 273.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See DSTN in Genome Data Viewer
    Location:
    20p12.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (17569173..17609919)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (17550720..17590564)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene proprotein convertase subtilisin/kexin type 2 Neighboring gene dynein light chain Tctex-type 3 pseudogene 1 Neighboring gene beaded filament structural protein 1 Neighboring gene RPS27A pseudogene 2 Neighboring gene ras homolog family member G pseudogene Neighboring gene RN7SK pseudogene 69 Neighboring gene ribosome binding protein 1 Neighboring gene uncharacterized LOC105372547 Neighboring gene BANF family member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study of antiphospholipid antibodies.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin filament fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin polymerization or depolymerization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    destrin
    Names
    actin-depolymerizing factor
    bA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP))
    epididymis luminal protein 32
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011546.2NP_001011546.1  destrin isoform b

      See identical proteins and their annotated locations for NP_001011546.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional segment in the coding region compared to variant 1. This difference causes translation initiation at a downstream ATG and an isoform (b) with a shorter N-terminus compared to an isoform a.
      Source sequence(s)
      AI597935, AL132765, BC009477, BX647319, S65738
      Consensus CDS
      CCDS46580.1
      UniProtKB/Swiss-Prot
      P60981
      Related
      ENSP00000476975.1, ENST00000474024.5
      Conserved Domains (1) summary
      smart00102
      Location:2136
      ADF; Actin depolymerisation factor/cofilin -like domains
    2. NM_006870.4NP_006861.1  destrin isoform a

      See identical proteins and their annotated locations for NP_006861.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript, but encodes the longer isoform (a).
      Source sequence(s)
      AI597935, AL132765, BC009477, S65738
      Consensus CDS
      CCDS13127.1
      UniProtKB/Swiss-Prot
      P60981
      UniProtKB/TrEMBL
      V9HWA6
      Related
      ENSP00000246069.6, ENST00000246069.12
      Conserved Domains (1) summary
      cd11286
      Location:3152
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

      Range
      17569173..17609919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529144.1XP_011527446.1  destrin isoform X1

      See identical proteins and their annotated locations for XP_011527446.1

      UniProtKB/Swiss-Prot
      P60981
      Conserved Domains (1) summary
      smart00102
      Location:2136
      ADF; Actin depolymerisation factor/cofilin -like domains
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