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    LILRA3 leukocyte immunoglobulin like receptor A3 [ Homo sapiens (human) ]

    Gene ID: 11026, updated on 5-Aug-2018

    Summary

    Official Symbol
    LILRA3provided by HGNC
    Official Full Name
    leukocyte immunoglobulin like receptor A3provided by HGNC
    Primary source
    HGNC:HGNC:6604
    See related
    MIM:604818
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4
    Summary
    This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]
    Annotation information
    Annotation category: only annotated on alternate loci in reference assembly
    Orthologs

    Genomic context

    See LILRA3 in Genome Data Viewer
    Location:
    19q13.4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_9) NT_187693.1 (270964..275379, complement)
    109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_1) NW_003571054.1 (270735..275150, complement)
    109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_2) NW_003571055.2 (270616..275031, complement)
    109 current GRCh38.p12 (GCF_000001405.38) 19 (ALT_REF_LOCI_8) NW_003571061.2 (270991..275406, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54799854..54804625, complement)

    NW_003571054.1Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B2 Neighboring gene microRNA 4752 Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene vomeronasal 1 receptor 104 pseudogene

    NW_003571055.2Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin-like receptor subfamily B member 3 Neighboring gene microRNA 4752 Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene vomeronasal 1 receptor 104 pseudogene

    NW_003571061.2Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B2 Neighboring gene microRNA 4752 Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene vomeronasal 1 receptor 104 pseudogene

    NT_187693.1Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B2 Neighboring gene microRNA 4752 Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene vomeronasal 1 receptor 104 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    antigen binding TAS
    Traceable Author Statement
    more info
    PubMed 
    signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    specific granule membrane TAS
    Traceable Author Statement
    more info
     
    tertiary granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    leukocyte immunoglobulin-like receptor subfamily A member 3
    Names
    CD85 antigen-like family member E
    immunoglobulin-like transcript 6
    leucocyte Ig-like receptor A3
    leukocyte immunoglobulin-like receptor 4
    leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
    monocyte inhibitory receptor HM43/HM31

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034046.1 RefSeqGene

      Range
      5001..9416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001172654.2NP_001166125.1  leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AF014924, AI655471, BX280714
      UniProtKB/Swiss-Prot
      Q8N6C8
      Conserved Domains (3) summary
      cd05751
      Location:27119
      Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
      smart00410
      Location:271333
      IG_like; Immunoglobulin like
      cl11960
      Location:261355
      Ig; Immunoglobulin domain
    2. NM_006865.4NP_006856.3  leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF014923, AF025527, AI655471
      UniProtKB/Swiss-Prot
      Q8N6C8
      Conserved Domains (3) summary
      cd05751
      Location:27119
      Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
      smart00410
      Location:335397
      IG_like; Immunoglobulin like
      cl11960
      Location:124219
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 ALT_REF_LOCI_1

    Genomic

    1. NW_003571054.1 Reference GRCh38.p12 ALT_REF_LOCI_1

      Range
      270735..275150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p12 ALT_REF_LOCI_2

    Genomic

    1. NW_003571055.2 Reference GRCh38.p12 ALT_REF_LOCI_2

      Range
      270616..275031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p12 ALT_REF_LOCI_8

    Genomic

    1. NW_003571061.2 Reference GRCh38.p12 ALT_REF_LOCI_8

      Range
      270991..275406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p12 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p12 ALT_REF_LOCI_9

      Range
      270964..275379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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