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    TNFSF13B TNF superfamily member 13b [ Homo sapiens (human) ]

    Gene ID: 10673, updated on 28-Nov-2021

    Summary

    Official Symbol
    TNFSF13Bprovided by HGNC
    Official Full Name
    TNF superfamily member 13bprovided by HGNC
    Primary source
    HGNC:HGNC:11929
    See related
    Ensembl:ENSG00000102524 MIM:603969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNLG7A; TNFSF20
    Summary
    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
    Expression
    Broad expression in appendix (RPKM 11.4), lymph node (RPKM 7.1) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TNFSF13B in Genome Data Viewer
    Location:
    13q33.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (108268240..108308484)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (108921977..108960832)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13792 Neighboring gene DNA ligase 4 Neighboring gene abhydrolase domain containing 13 Neighboring gene RNA, 5S ribosomal pseudogene 39 Neighboring gene uncharacterized LOC105370355 Neighboring gene host cell factor C2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 cooperates with BAFF and cytokines IL-4 and IL-10 to activate mannose C-type lectin receptors-expressing B cells PubMed
    Nef nef HIV-1 Nef upregulates levels of B lymphocyte stimulator (BLyS) expression in monocyte-derived DCs PubMed
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of tumor necrosis factor superfamily, member 13b (TNFSF13B) in primary human brain microvascular endothelial cells PubMed
    integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that TNFSF13B gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with TNFSF13B PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B cell costimulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell costimulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of B cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of germinal center formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    located_in integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor ligand superfamily member 13B
    Names
    ApoL related ligand TALL-1
    B-cell-activating factor
    B-lymphocyte stimulator
    Delta4 BAFF
    TNF and ApoL-related leukocyte expressed ligand 1
    TNF homolog that activates apoptosis
    delta BAFF
    dendritic cell-derived TNF-like molecule
    epididymis secretory sperm binding protein
    tumor necrosis factor (ligand) superfamily, member 13b
    tumor necrosis factor (ligand) superfamily, member 20
    tumor necrosis factor ligand 7A
    tumor necrosis factor superfamily member 13b
    tumor necrosis factor-like protein ZTNF4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029524.1 RefSeqGene

      Range
      5001..43856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145645.2NP_001139117.1  tumor necrosis factor ligand superfamily member 13B isoform 2

      See identical proteins and their annotated locations for NP_001139117.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) omits an in-frame coding exon, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AL157762, AY302751, BI818459, BQ778438
      Consensus CDS
      CCDS45067.1
      UniProtKB/Swiss-Prot
      Q9Y275
      Related
      ENSP00000389540.1, ENST00000430559.5
      Conserved Domains (1) summary
      cd00184
      Location:135263
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    2. NM_006573.5NP_006564.1  tumor necrosis factor ligand superfamily member 13B isoform 1

      See identical proteins and their annotated locations for NP_006564.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents a longer transcript and encodes the longer protein isoform (1).
      Source sequence(s)
      AL157762
      Consensus CDS
      CCDS9509.1
      UniProtKB/Swiss-Prot
      Q9Y275
      UniProtKB/TrEMBL
      A0A0U5J7Q1
      Related
      ENSP00000365048.3, ENST00000375887.9
      Conserved Domains (1) summary
      cd00184
      Location:146282
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      108268240..108308484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001749468.1 RNA Sequence

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