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    RGS14 regulator of G protein signaling 14 [ Homo sapiens (human) ]

    Gene ID: 10636, updated on 13-Feb-2019

    Summary

    Official Symbol
    RGS14provided by HGNC
    Official Full Name
    regulator of G protein signaling 14provided by HGNC
    Primary source
    HGNC:HGNC:9996
    See related
    Ensembl:ENSG00000169220 MIM:602513
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 15.0), lymph node (RPKM 11.5) and 23 other tissues See more
    Orthologs

    Genomic context

    See RGS14 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (177357671..177372601)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176784704..176799599)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene PRELI domain containing 1 Neighboring gene MAX dimerization protein 3 Neighboring gene lectin, mannose binding 2 Neighboring gene ribosomal protein S20 pseudogene 17 Neighboring gene VISTA enhancer hs2229 Neighboring gene solute carrier family 34 member 1 Neighboring gene profilin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.
    NHGRI GWA Catalog
    Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
    NHGRI GWA Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.
    NHGRI GWA Catalog
    New loci associated with kidney function and chronic kidney disease.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein alpha-subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    GDP-dissociation inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activating protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activity TAS
    Traceable Author Statement
    more info
     
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    receptor signaling complex scaffold activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long-term memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleocytoplasmic transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    platelet-derived growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of DNA-templated transcription in response to stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    visual learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zygote asymmetric cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    PML body IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    regulator of G-protein signaling 14

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001366617.1NP_001353546.1  regulator of G-protein signaling 14 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC146507
      Conserved Domains (5) summary
      smart00455
      Location:376445
      RBD; Raf-like Ras-binding domain
      cd01817
      Location:303376
      RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
      cd08743
      Location:58186
      RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
      smart00390
      Location:499521
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam16613
      Location:189273
      RGS12_us1; Unstructured region of RGS12
    2. NM_001366618.1NP_001353547.1  regulator of G-protein signaling 14 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC146507
    3. NM_006480.5NP_006471.2  regulator of G-protein signaling 14 isoform 1

      See identical proteins and their annotated locations for NP_006471.2

      Status: REVIEWED

      Source sequence(s)
      BC014094
      Consensus CDS
      CCDS43405.1
      UniProtKB/Swiss-Prot
      O43566
      Related
      ENSP00000386229.3, ENST00000408923.7
      Conserved Domains (4) summary
      smart00455
      Location:375444
      RBD; Raf-like Ras-binding domain
      cd01817
      Location:303375
      RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
      cd08743
      Location:58186
      RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
      smart00390
      Location:498520
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

      Range
      177357671..177372601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005265795.5XP_005265852.1  regulator of G-protein signaling 14 isoform X3

      Conserved Domains (4) summary
      smart00455
      Location:376445
      RBD; Raf-like Ras-binding domain
      cd01817
      Location:303376
      RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
      cd08743
      Location:58186
      RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
      pfam16613
      Location:189273
      RGS12_us1; Unstructured region of RGS12
    2. XM_024454328.1XP_024310096.1  regulator of G-protein signaling 14 isoform X1

      Conserved Domains (5) summary
      smart00455
      Location:376445
      RBD; Raf-like Ras-binding domain
      cd01817
      Location:303376
      RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
      cd08743
      Location:58186
      RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
      smart00390
      Location:525547
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam16613
      Location:189273
      RGS12_us1; Unstructured region of RGS12
    3. XM_005265794.4XP_005265851.1  regulator of G-protein signaling 14 isoform X2

      UniProtKB/TrEMBL
      A0A024R7N4
      Conserved Domains (5) summary
      smart00455
      Location:376445
      RBD; Raf-like Ras-binding domain
      cd01817
      Location:303376
      RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
      cd08743
      Location:58186
      RGS_RGS14; Regulator of G protein signaling (RGS) domain found in the RGS14 protein
      smart00390
      Location:499521
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam16613
      Location:189273
      RGS12_us1; Unstructured region of RGS12
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