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    POLR3G RNA polymerase III subunit G [ Homo sapiens (human) ]

    Gene ID: 10622, updated on 9-Sep-2018

    Summary

    Official Symbol
    POLR3Gprovided by HGNC
    Official Full Name
    RNA polymerase III subunit Gprovided by HGNC
    Primary source
    HGNC:HGNC:30075
    See related
    Ensembl:ENSG00000113356 MIM:617456; Vega:OTTHUMG00000162809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPC7; RPC32
    Expression
    Broad expression in testis (RPKM 1.8), esophagus (RPKM 1.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See POLR3G in Genome Data Viewer
    Location:
    5q14.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (90473929..90514555)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (89769876..89810474)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC731157 Neighboring gene centrin 3 Neighboring gene metallo-beta-lactamase domain containing 2 Neighboring gene LysM domain containing 3 Neighboring gene adhesion G protein-coupled receptor V1 Neighboring gene uncharacterized LOC105379077

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell proliferation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription by RNA polymerase III TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA-directed RNA polymerase III subunit RPC7
    Names
    DNA-directed RNA polymerase III 32 kDa polypeptide
    DNA-directed RNA polymerase III subunit G
    RNA polymerase III 32 kDa apha subunit
    RNA polymerase III 32 kDa subunit
    RNA polymerase III subunit C7
    RPC32-alpha
    polymerase (RNA) III (DNA directed) polypeptide G (32kD)
    polymerase (RNA) III subunit G

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006467.2NP_006458.2  DNA-directed RNA polymerase III subunit RPC7

      See identical proteins and their annotated locations for NP_006458.2

      Status: VALIDATED

      Source sequence(s)
      AC027323, BM788728, BP348952, CD657312
      Consensus CDS
      CCDS43337.1
      UniProtKB/Swiss-Prot
      O15318
      UniProtKB/TrEMBL
      A0A024RAM1
      Related
      ENSP00000382058.1, ENST00000399107.5
      Conserved Domains (1) summary
      pfam11705
      Location:1220
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

      Range
      90473929..90514555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543100.3XP_011541402.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

      See identical proteins and their annotated locations for XP_011541402.1

      UniProtKB/Swiss-Prot
      O15318
      UniProtKB/TrEMBL
      A0A024RAM1
      Related
      ENSP00000422892.1, OTTHUMP00000222697, ENST00000503373.5
      Conserved Domains (1) summary
      pfam11705
      Location:1220
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
    2. XM_011543101.3XP_011541403.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

      See identical proteins and their annotated locations for XP_011541403.1

      UniProtKB/Swiss-Prot
      O15318
      UniProtKB/TrEMBL
      A0A024RAM1
      Conserved Domains (1) summary
      pfam11705
      Location:1220
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
    3. XM_017008957.2XP_016864446.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

      UniProtKB/Swiss-Prot
      O15318
      UniProtKB/TrEMBL
      A0A024RAM1
      Conserved Domains (1) summary
      pfam11705
      Location:1220
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
    4. XM_011543104.3XP_011541406.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

      See identical proteins and their annotated locations for XP_011541406.1

      Conserved Domains (1) summary
      pfam11705
      Location:1219
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
    5. XM_011543102.3XP_011541404.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

      See identical proteins and their annotated locations for XP_011541404.1

      UniProtKB/Swiss-Prot
      O15318
      UniProtKB/TrEMBL
      A0A024RAM1
      Conserved Domains (1) summary
      pfam11705
      Location:1220
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
    6. XM_011543103.3XP_011541405.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

      See identical proteins and their annotated locations for XP_011541405.1

      Conserved Domains (1) summary
      pfam11705
      Location:1219
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
    7. XM_005248404.4XP_005248461.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

      See identical proteins and their annotated locations for XP_005248461.1

      UniProtKB/Swiss-Prot
      O15318
      UniProtKB/TrEMBL
      A0A024RAM1
      Related
      ENSP00000421637.1, OTTHUMP00000222694, ENST00000504930.5
      Conserved Domains (1) summary
      pfam11705
      Location:1220
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
    8. XM_011543105.3XP_011541407.1  DNA-directed RNA polymerase III subunit RPC7 isoform X3

      Conserved Domains (1) summary
      pfam11705
      Location:1164
      RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
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