Format

Send to:

Choose Destination
    • Showing Current items.

    ATG7 autophagy related 7 [ Homo sapiens (human) ]

    Gene ID: 10533, updated on 14-Jun-2018
    Official Symbol
    ATG7provided by HGNC
    Official Full Name
    autophagy related 7provided by HGNC
    Primary source
    HGNC:HGNC:16935
    See related
    Ensembl:ENSG00000197548 MIM:608760; Vega:OTTHUMG00000129740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GSA7; APG7L; APG7-LIKE
    Summary
    This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in ovary (RPKM 10.0), thyroid (RPKM 8.3) and 25 other tissues See more
    Orthologs
    See ATG7 in Genome Data Viewer
    Location:
    3p25.3
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (11272324..11564652)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (11314010..11599139)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723663 Neighboring gene histamine receptor H1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 4 Neighboring gene uncharacterized LOC105376952 Neighboring gene vestigial like family member 4 Neighboring gene TAM41 mitochondrial translocator assembly and maintenance homolog

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
    NHGRI GWA Catalog
    Discovery and refinement of loci associated with lipid levels.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of autophagy related 7 homolog (ATG7) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The siRNA-mediated reduction of ATG7 protein reverses Torin-1-induced HIV-1 Tat degradation, suggesting ATG7 is involved in the lysosomal-mediated Tat degradation PubMed
    capsid gag Knockdown of autophagy factor ATG7 results in diminished levels of p24 yields in both primary monocyte- and U937-derived macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - other, organism-specific biosystem (from KEGG)
      Autophagy - other, organism-specific biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
    • Autophagy - other, conserved biosystem (from KEGG)
      Autophagy - other, conserved biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • Ferroptosis, organism-specific biosystem (from KEGG)
      Ferroptosis, organism-specific biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
    • Ferroptosis, conserved biosystem (from KEGG)
      Ferroptosis, conserved biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Macroautophagy, organism-specific biosystem (from REACTOME)
      Macroautophagy, organism-specific biosystemMacroautophagy (hereafter referred to as autophagy) acts as a buffer against starvation by liberating building materials and energy sources from cellular components. It has additional roles in embryo...
    • Nanoparticle triggered autophagic cell death, organism-specific biosystem (from WikiPathways)
      Nanoparticle triggered autophagic cell death, organism-specific biosystemProgrammed cell death: autophagic cell death. Autophagy (self-eating) is a survival mechanism deployed by cells to cope with conditions of nutrient deprivation. However, unrestrained autophagy can re...
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • Oncogenic MAPK signaling, organism-specific biosystem (from REACTOME)
      Oncogenic MAPK signaling, organism-specific biosystemThe importance of the RAS/RAF/MAPK cascade in regulating cellular proliferation, differentiation and survival is highlighted by the fact that components of the pathway are mutated with high frequency...
    • Senescence and Autophagy in Cancer, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy in Cancer, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Signaling by BRAF and RAF fusions, organism-specific biosystem (from REACTOME)
      Signaling by BRAF and RAF fusions, organism-specific biosystemIn addition to the more prevalent point mutations, BRAF and RAF1 are also subject to activation as a result of translocation events that yield truncated or fusion products (Jones et al, 2008; Cin et ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp434N0735

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Atg12 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Atg12 activating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Atg8 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin activating enzyme activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    C-terminal protein lipidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    autophagy of host cells involved in interaction with symbiont IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagy of mitochondrion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular protein modification process TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to hyperoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    late nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    macroautophagy TAS
    Traceable Author Statement
    more info
     
    membrane fusion TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of mitochondrial DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of oxidative stress-induced neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein modification process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein lipidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    response to fluoride IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    suppression by virus of host autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    ubiquitin-like modifier-activating enzyme ATG7
    Names
    APG7 autophagy 7-like
    ATG12-activating enzyme E1 ATG7
    hAGP7
    ubiquitin-activating enzyme E1-like protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136031.2NP_001129503.2  ubiquitin-like modifier-activating enzyme ATG7 isoform b

      See identical proteins and their annotated locations for NP_001129503.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform b.
      Source sequence(s)
      AC022001, AC083855, AL122075, BC000091, DA177126
      Consensus CDS
      CCDS46752.1
      UniProtKB/Swiss-Prot
      O95352
      Related
      ENSP00000347042.5, OTTHUMP00000207592, ENST00000354956.9, OTTHUMT00000339095
      Conserved Domains (1) summary
      cl25654
      Location:15675
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    2. NM_001144912.1NP_001138384.1  ubiquitin-like modifier-activating enzyme ATG7 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform c.
      Source sequence(s)
      AC022001, AC083855, AK303694, AL122075, BC000091, DA177126
      Consensus CDS
      CCDS46753.1
      UniProtKB/Swiss-Prot
      O95352
      Related
      ENSP00000412580.2, OTTHUMP00000207591, ENST00000446450.6, OTTHUMT00000339093
      Conserved Domains (3) summary
      cd01486
      Location:318616
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15614
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13282
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    3. NM_001349232.1NP_001336161.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (a). Variants 1, 4, 5, 6, and 7 all encode the same isoform (a).
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Consensus CDS
      CCDS2605.1
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    4. NM_001349233.1NP_001336162.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 4, 6, and 7, encodes the longest isoform (a).
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Consensus CDS
      CCDS2605.1
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    5. NM_001349234.1NP_001336163.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 4, 5, and 7, encodes the longest isoform (a).
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Consensus CDS
      CCDS2605.1
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    6. NM_001349235.1NP_001336164.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 4, 5, and 6, encodes the longest isoform (a).
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Consensus CDS
      CCDS2605.1
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    7. NM_001349236.1NP_001336165.1  ubiquitin-like modifier-activating enzyme ATG7 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) encodes isoform d.
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Conserved Domains (1) summary
      cl25654
      Location:15663
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    8. NM_001349237.1NP_001336166.1  ubiquitin-like modifier-activating enzyme ATG7 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) encodes isoform e.
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Conserved Domains (1) summary
      cl25654
      Location:15649
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    9. NM_001349238.1NP_001336167.1  ubiquitin-like modifier-activating enzyme ATG7 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) encodes isoform f.
      Source sequence(s)
      AC020750, AC022001, AC026185, AC083855
      Conserved Domains (1) summary
      cd01486
      Location:46371
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
    10. NM_006395.2NP_006386.1  ubiquitin-like modifier-activating enzyme ATG7 isoform a

      See identical proteins and their annotated locations for NP_006386.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 4, 5, 6, and 7, encodes the longest isoform (a).
      Source sequence(s)
      AC022001, AC083855, AK075221, AL122075, BC000091, DA177126
      Consensus CDS
      CCDS2605.1
      UniProtKB/Swiss-Prot
      O95352
      UniProtKB/TrEMBL
      B3KQM6
      Related
      ENSP00000346437.3, OTTHUMP00000160157, ENST00000354449.7, OTTHUMT00000251951
      Conserved Domains (1) summary
      cl25654
      Location:15702
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      11272324..11564652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005547.2XP_016861036.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X5

    2. XM_011533286.2XP_011531588.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X10

      See identical proteins and their annotated locations for XP_011531588.1

      UniProtKB/Swiss-Prot
      O95352
      Conserved Domains (1) summary
      cl25654
      Location:15675
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    3. XM_011533283.2XP_011531585.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X6

      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    4. XM_011533285.3XP_011531587.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X8

      Conserved Domains (3) summary
      TIGR01381
      Location:15640
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
      cl22428
      Location:357629
      E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...
    5. XM_011533280.2XP_011531582.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X3

      Conserved Domains (3) summary
      cd01486
      Location:357655
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15666
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    6. XM_011533277.3XP_011531579.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      See identical proteins and their annotated locations for XP_011531579.1

      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    7. XM_011533281.2XP_011531583.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X4

      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15695
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    8. XM_011533284.2XP_011531586.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X7

      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    9. XM_011533279.2XP_011531581.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X2

      Conserved Domains (1) summary
      cl25654
      Location:15694
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    10. XM_017005549.2XP_016861038.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X8

      Conserved Domains (3) summary
      TIGR01381
      Location:15640
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
      cl22428
      Location:357629
      E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...
    11. XM_006712932.4XP_006712995.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      See identical proteins and their annotated locations for XP_006712995.1

      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    12. XM_017005548.1XP_016861037.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X6

      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15697
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    13. XM_017005551.1XP_016861040.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X11

    14. XM_017005543.1XP_016861032.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X3

      Conserved Domains (3) summary
      cd01486
      Location:357655
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15666
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    15. XM_006712931.4XP_006712994.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      See identical proteins and their annotated locations for XP_006712994.1

      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    16. XM_024453312.1XP_024309080.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X2

      Conserved Domains (1) summary
      cl25654
      Location:15694
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    17. XM_017005550.1XP_016861039.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X9

    18. XM_011533278.2XP_011531580.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      See identical proteins and their annotated locations for XP_011531580.1

      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    19. XM_024453315.1XP_024309083.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X13

      Conserved Domains (1) summary
      cd01486
      Location:46371
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
    20. XM_024453314.1XP_024309082.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X12

      Conserved Domains (1) summary
      cd01486
      Location:46371
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
    21. XM_006712933.3XP_006712996.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      See identical proteins and their annotated locations for XP_006712996.1

      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    22. XM_017005542.1XP_016861031.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

      Conserved Domains (3) summary
      cd01486
      Location:357682
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:15693
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:13321
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    23. XM_024453313.1XP_024309081.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X12

      Conserved Domains (1) summary
      cd01486
      Location:46371
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...

    RNA

    1. XR_940363.2 RNA Sequence

    2. XR_001739980.2 RNA Sequence

    Support Center