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    SEMA4D semaphorin 4D [ Homo sapiens (human) ]

    Gene ID: 10507, updated on 16-Oct-2021

    Summary

    Official Symbol
    SEMA4Dprovided by HGNC
    Official Full Name
    semaphorin 4Dprovided by HGNC
    Primary source
    HGNC:HGNC:10732
    See related
    Ensembl:ENSG00000187764 MIM:601866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A8; GR3; BB18; CD100; COLL4; SEMAJ; coll-4; C9orf164; M-sema-G
    Expression
    Broad expression in lymph node (RPKM 12.0), appendix (RPKM 8.6) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SEMA4D in Genome Data Viewer
    Location:
    9q22.2
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (89360787..89498113, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (91975702..92113028, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376136 Neighboring gene microRNA 3153 Neighboring gene SECIS binding protein 2 Neighboring gene CDC28 protein kinase regulatory subunit 2 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene proliferation-associated 2G4 pseudogene 6 Neighboring gene uncharacterized LOC105376137 Neighboring gene uncharacterized LOC105376139

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SEMA4D PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of semaphoring-4D (SEMA4D) in human B cells PubMed
    Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD100 PubMed
    Tat tat Microarray analysis indicates HIV-1 Tat upregulates the expression of many proteins, including Semaphorin (CD100), in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
    Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD100 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ33485, FLJ34282, FLJ39737, FLJ46484, MGC169138, MGC169141

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables semaphorin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables semaphorin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables semaphorin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in leukocyte aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of alkaline phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of axon extension involved in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ossification involved in bone maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ossification involved in bone maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of collateral sprouting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of inhibitory synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell projection organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    semaphorin-4D
    Names
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142287.2NP_001135759.1  semaphorin-4D isoform 2 precursor

      See identical proteins and their annotated locations for NP_001135759.1

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
      Consensus CDS
      CCDS47991.1
      UniProtKB/Swiss-Prot
      Q92854
      Related
      ENSP00000391733.1, ENST00000420987.5
      Conserved Domains (4) summary
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      pfam01437
      Location:503554
      PSI; Plexin repeat
      cd00096
      Location:604612
      Ig; Ig strand A [structural motif]
      cl11960
      Location:603690
      Ig; Immunoglobulin domain
    2. NM_001371194.2NP_001358123.1  semaphorin-4D isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
      Related
      ENSP00000388768.2, ENST00000422704.7
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    3. NM_001371195.1NP_001358124.1  semaphorin-4D isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    4. NM_001371196.1NP_001358125.1  semaphorin-4D isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    5. NM_001371197.1NP_001358126.1  semaphorin-4D isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    6. NM_001371198.1NP_001358127.1  semaphorin-4D isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
      Conserved Domains (4) summary
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      pfam01437
      Location:503554
      PSI; Plexin repeat
      cd00096
      Location:604612
      Ig; Ig strand A [structural motif]
      cl11960
      Location:603690
      Ig; Immunoglobulin domain
    7. NM_001371199.1NP_001358128.1  semaphorin-4D isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
      Related
      ENSP00000344923.4, ENST00000339861.8
      Conserved Domains (4) summary
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      pfam01437
      Location:503554
      PSI; Plexin repeat
      cd00096
      Location:604612
      Ig; Ig strand A [structural motif]
      cl11960
      Location:603690
      Ig; Immunoglobulin domain
    8. NM_001371200.1NP_001358129.1  semaphorin-4D isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
      Conserved Domains (4) summary
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      pfam01437
      Location:503554
      PSI; Plexin repeat
      cd00096
      Location:604612
      Ig; Ig strand A [structural motif]
      cl11960
      Location:603690
      Ig; Immunoglobulin domain
    9. NM_001371201.1NP_001358130.1  semaphorin-4D isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
      Conserved Domains (4) summary
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      pfam01437
      Location:503554
      PSI; Plexin repeat
      cd00096
      Location:604612
      Ig; Ig strand A [structural motif]
      cl11960
      Location:603690
      Ig; Immunoglobulin domain
    10. NM_001371202.1NP_001358131.1  semaphorin-4D isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
      Conserved Domains (2) summary
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    11. NM_006378.4NP_006369.3  semaphorin-4D isoform 1 precursor

      See identical proteins and their annotated locations for NP_006369.3

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
      Consensus CDS
      CCDS6685.1
      UniProtKB/Swiss-Prot
      Q92854
      Related
      ENSP00000405102.2, ENST00000438547.6
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins

    RNA

    1. NR_163884.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    2. NR_163885.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    3. NR_163886.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    4. NR_163887.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    5. NR_163888.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    6. NR_163889.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      89360787..89498113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518133.2XP_011516435.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516435.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    2. XM_011518125.1XP_011516427.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516427.1

      UniProtKB/Swiss-Prot
      Q92854
      Related
      ENSP00000348822.2, ENST00000356444.6
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    3. XM_011518128.2XP_011516430.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516430.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    4. XM_011518127.2XP_011516429.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516429.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    5. XM_011518123.2XP_011516425.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516425.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    6. XM_011518129.1XP_011516431.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516431.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    7. XM_017014198.1XP_016869687.1  semaphorin-4D isoform X1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    8. XM_017014195.1XP_016869684.1  semaphorin-4D isoform X1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    9. XM_017014194.1XP_016869683.1  semaphorin-4D isoform X1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    10. XM_011518124.2XP_011516426.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516426.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    11. XM_017014193.2XP_016869682.1  semaphorin-4D isoform X1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    12. XM_011518131.2XP_011516433.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516433.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    13. XM_011518130.2XP_011516432.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516432.1

      UniProtKB/Swiss-Prot
      Q92854
      Related
      ENSP00000416523.1, ENST00000450295.5
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    14. XM_011518134.2XP_011516436.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516436.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (3) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00423
      Location:503554
      PSI; domain found in Plexins, Semaphorins and Integrins
    15. XM_017014199.1XP_016869688.1  semaphorin-4D isoform X2

      Related
      ENSP00000446394.1, ENST00000537934.5
      Conserved Domains (1) summary
      cd11259
      Location:31485
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)

    RNA

    1. XR_001746153.1 RNA Sequence

    2. XR_001746156.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182635.1: Suppressed sequence

      Description
      NM_182635.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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