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    SEMA4D semaphorin 4D [ Homo sapiens (human) ]

    Gene ID: 10507, updated on 3-Jul-2019

    Summary

    Official Symbol
    SEMA4Dprovided by HGNC
    Official Full Name
    semaphorin 4Dprovided by HGNC
    Primary source
    HGNC:HGNC:10732
    See related
    Ensembl:ENSG00000187764 MIM:601866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A8; GR3; BB18; CD100; COLL4; SEMAJ; coll-4; C9orf164; M-sema-G
    Expression
    Broad expression in lymph node (RPKM 12.0), appendix (RPKM 8.6) and 22 other tissues See more
    Orthologs

    Genomic context

    See SEMA4D in Genome Data Viewer
    Location:
    9q22.2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (89360791..89498065, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (91975706..92112906, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376136 Neighboring gene microRNA 3153 Neighboring gene SECIS binding protein 2 Neighboring gene CDC28 protein kinase regulatory subunit 2 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene proliferation-associated 2G4 pseudogene 6 Neighboring gene uncharacterized LOC105376137 Neighboring gene uncharacterized LOC105376139

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SEMA4D PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of semaphoring-4D (SEMA4D) in human B cells PubMed
    Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD100 PubMed
    Tat tat Microarray analysis indicates HIV-1 Tat upregulates the expression of many proteins, including Semaphorin (CD100), in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
    Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD100 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Other semaphorin interactions, organism-specific biosystem (from REACTOME)
      Other semaphorin interactions, organism-specific biosystemThere are eight classes of semaphorins and four types of plexins. Semaphorin (SEMA) classes 1 and 2 are found in invertebrates and classes 3-7 are vertebrate sempahorines. Sempahorin class 3 is secre...
    • Sema4D in semaphorin signaling, organism-specific biosystem (from REACTOME)
      Sema4D in semaphorin signaling, organism-specific biosystemSemaphorin 4D (Sema 4D/CD100) is an axon guidance molecule with two disulfide-linked 150-kDa subunits. SEMA4D is structurally defined by a conserved 500-amino acid extracellular domain with 16 cyste...
    • Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem (from REACTOME)
      Sema4D induced cell migration and growth-cone collapse, organism-specific biosystemSema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates ML...
    • Sema4D mediated inhibition of cell attachment and migration, organism-specific biosystem (from REACTOME)
      Sema4D mediated inhibition of cell attachment and migration, organism-specific biosystemRepulsive Sema4D-Plexin-B1 signaling involves four GTPases, Rnd1, R-Ras, Rho and Rac1. Sema4D-Plexin-B1 binding promotes Rnd1-dependent activation of the plexin-B1 GAP domain and transient suppressio...
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ33485, FLJ34282, FLJ39737, FLJ46484, MGC169138, MGC169141

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuropilin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    semaphorin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    semaphorin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    semaphorin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    leukocyte aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of alkaline phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of axon extension involved in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ossification involved in bone maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ossification involved in bone maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of collateral sprouting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of inhibitory synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell projection organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    semaphorin-plexin signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    semaphorin-plexin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    semaphorin-4D
    Names
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142287.2NP_001135759.1  semaphorin-4D isoform 2 precursor

      See identical proteins and their annotated locations for NP_001135759.1

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
      Consensus CDS
      CCDS47991.1
      UniProtKB/Swiss-Prot
      Q92854
      Related
      ENSP00000391733.1, ENST00000420987.5
      Conserved Domains (3) summary
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      pfam01437
      Location:503554
      PSI; Plexin repeat
      cl11960
      Location:600679
      Ig; Immunoglobulin domain
    2. NM_001371194.1NP_001358123.1  semaphorin-4D isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    3. NM_001371195.1NP_001358124.1  semaphorin-4D isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    4. NM_001371196.1NP_001358125.1  semaphorin-4D isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    5. NM_001371197.1NP_001358126.1  semaphorin-4D isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    6. NM_001371198.1NP_001358127.1  semaphorin-4D isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    7. NM_001371199.1NP_001358128.1  semaphorin-4D isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    8. NM_001371200.1NP_001358129.1  semaphorin-4D isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    9. NM_001371201.1NP_001358130.1  semaphorin-4D isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    10. NM_001371202.1NP_001358131.1  semaphorin-4D isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    11. NM_006378.4NP_006369.3  semaphorin-4D isoform 1 precursor

      See identical proteins and their annotated locations for NP_006369.3

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
      Consensus CDS
      CCDS6685.1
      UniProtKB/Swiss-Prot
      Q92854
      Related
      ENSP00000405102.2, ENST00000438547.6
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat

    RNA

    1. NR_163884.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    2. NR_163885.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    3. NR_163886.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    4. NR_163887.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    5. NR_163888.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575
    6. NR_163889.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL590233, AL929575

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      89360791..89498065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518133.2XP_011516435.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516435.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    2. XM_005251654.3XP_005251711.1  semaphorin-4D isoform X1

      UniProtKB/Swiss-Prot
      Q92854
      Related
      ENSP00000388768.2, ENST00000422704.6
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    3. XM_011518125.1XP_011516427.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516427.1

      UniProtKB/Swiss-Prot
      Q92854
      Related
      ENSP00000348822.2, ENST00000356444.6
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    4. XM_011518128.2XP_011516430.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516430.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    5. XM_011518127.2XP_011516429.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516429.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    6. XM_011518123.2XP_011516425.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516425.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    7. XM_011518129.1XP_011516431.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516431.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    8. XM_017014198.1XP_016869687.1  semaphorin-4D isoform X1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    9. XM_017014197.1XP_016869686.1  semaphorin-4D isoform X1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    10. XM_017014196.1XP_016869685.1  semaphorin-4D isoform X1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    11. XM_017014195.1XP_016869684.1  semaphorin-4D isoform X1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    12. XM_017014194.1XP_016869683.1  semaphorin-4D isoform X1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    13. XM_011518124.2XP_011516426.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516426.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    14. XM_017014193.2XP_016869682.1  semaphorin-4D isoform X1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    15. XM_011518131.2XP_011516433.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516433.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    16. XM_011518130.2XP_011516432.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516432.1

      UniProtKB/Swiss-Prot
      Q92854
      Related
      ENSP00000416523.1, ENST00000450295.5
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    17. XM_011518134.2XP_011516436.1  semaphorin-4D isoform X1

      See identical proteins and their annotated locations for XP_011516436.1

      UniProtKB/Swiss-Prot
      Q92854
      Conserved Domains (4) summary
      cd05873
      Location:559645
      Ig_Sema4D_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4D
      cd11259
      Location:31501
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)
      smart00410
      Location:569634
      IG_like; Immunoglobulin like
      pfam01437
      Location:503554
      PSI; Plexin repeat
    18. XM_017014199.1XP_016869688.1  semaphorin-4D isoform X2

      Conserved Domains (1) summary
      cd11259
      Location:31485
      Sema_4D; The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100)

    RNA

    1. XR_001746157.1 RNA Sequence

    2. XR_001746154.1 RNA Sequence

      Related
      ENST00000429836.5
    3. XR_242562.4 RNA Sequence

      Related
      ENST00000537934.5
    4. XR_001746158.1 RNA Sequence

    5. XR_001746155.1 RNA Sequence

    6. XR_001746153.1 RNA Sequence

    7. XR_001746156.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182635.1: Suppressed sequence

      Description
      NM_182635.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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