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    COG5 component of oligomeric golgi complex 5 [ Homo sapiens (human) ]

    Gene ID: 10466, updated on 12-May-2019

    Summary

    Official Symbol
    COG5provided by HGNC
    Official Full Name
    component of oligomeric golgi complex 5provided by HGNC
    Primary source
    HGNC:HGNC:14857
    See related
    Ensembl:ENSG00000164597 MIM:606821
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDG2I; GTC90; GOLTC1
    Summary
    The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 12.7), prostate (RPKM 10.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See COG5 in Genome Data Viewer
    Location:
    7q22.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (107201744..107564514, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (106842189..107204959, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Neighboring gene uncharacterized LOC105375441 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta Neighboring gene HMG-box transcription factor 1 Neighboring gene ribosomal protein L37a pseudogene 6 Neighboring gene G protein-coupled receptor 22 Neighboring gene dihydrouridine synthase 4 like Neighboring gene B cell receptor associated protein 29 Neighboring gene WBP1L pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
      Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
    • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
      COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
    • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
      ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
    • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
      Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
    • Intra-Golgi traffic, organism-specific biosystem (from REACTOME)
      Intra-Golgi traffic, organism-specific biosystemThe mammalian Golgi consists of at least three biochemically distinct cisternae, cis-, medial- and trans (reviewed in Szul and Sztul, 2011; Day et al, 2013). The structure and function of the Golgi a...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Retrograde transport at the Trans-Golgi-Network, organism-specific biosystem (from REACTOME)
      Retrograde transport at the Trans-Golgi-Network, organism-specific biosystemThe trans-Golgi network is the docking site for retrograde cargo from the endolysosomal system and the plasma membrane. Typical cargo includes recycling resident TGN proteins such as TGOLN2 (also kn...
    • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
      Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ41732, FLJ44289

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intra-Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    Golgi transport complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi transport complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi transport complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    membrane HDA PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    conserved oligomeric Golgi complex subunit 5
    Names
    13S golgi transport complex 1 90 kDa subunit
    COG complex subunit 5
    conserved oligomeric Golgi complex protein 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028095.2 RefSeqGene

      Range
      5001..367771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161520.1NP_001154992.1  conserved oligomeric Golgi complex subunit 5 isoform 3

      See identical proteins and their annotated locations for NP_001154992.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC002381, AC004492, AK314270, BC068540
      Consensus CDS
      CCDS55152.1
      UniProtKB/Swiss-Prot
      Q9UP83
      Related
      ENSP00000377228.2, ENST00000393603.6
      Conserved Domains (2) summary
      pfam10392
      Location:66189
      COG5; Golgi transport complex subunit 5
      cl00549
      Location:702780
      ABC_membrane; ABC transporter transmembrane region
    2. NM_006348.3NP_006339.3  conserved oligomeric Golgi complex subunit 5 isoform 1

      See identical proteins and their annotated locations for NP_006339.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC002381, AC004492, AK314270, BC068540
      Consensus CDS
      CCDS5742.1
      UniProtKB/Swiss-Prot
      Q9UP83
      Related
      ENSP00000297135.3, ENST00000297135.7
      Conserved Domains (2) summary
      pfam10392
      Location:66189
      COG5; Golgi transport complex subunit 5
      cl00549
      Location:702780
      ABC_membrane; ABC transporter transmembrane region
    3. NM_181733.2NP_859422.2  conserved oligomeric Golgi complex subunit 5 isoform 2

      See identical proteins and their annotated locations for NP_859422.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC002381, AC004492, AF058718, AK314270, BC068540
      Consensus CDS
      CCDS5743.1
      UniProtKB/Swiss-Prot
      Q9UP83
      Related
      ENSP00000334703.2, ENST00000347053.7
      Conserved Domains (2) summary
      pfam10392
      Location:66189
      COG5; Golgi transport complex subunit 5
      cl00549
      Location:681759
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      107201744..107564514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446634.1XP_024302402.1  conserved oligomeric Golgi complex subunit 5 isoform X1

      Conserved Domains (1) summary
      pfam10392
      Location:66189
      COG5; Golgi transport complex subunit 5

    Reference GRCh38.p12 PATCHES

    Genomic

    1. NW_017852930.1 Reference GRCh38.p12 PATCHES

      Range
      47266..410169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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