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    TLR6 toll like receptor 6 [ Homo sapiens (human) ]

    Gene ID: 10333, updated on 18-Nov-2018

    Summary

    Official Symbol
    TLR6provided by HGNC
    Official Full Name
    toll like receptor 6provided by HGNC
    Primary source
    HGNC:HGNC:16711
    See related
    Ensembl:ENSG00000174130 MIM:605403; Vega:OTTHUMG00000128579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD286
    Summary
    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]
    Expression
    Broad expression in appendix (RPKM 4.9), spleen (RPKM 4.1) and 20 other tissues See more
    Orthologs

    Genomic context

    See TLR6 in Genome Data Viewer
    Location:
    4p14
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (38823680..38857767, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (38825325..38858438, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene toll like receptor 10 Neighboring gene toll like receptor 1 Neighboring gene family with sequence similarity 114 member A1 Neighboring gene microRNA 574 Neighboring gene transmembrane protein 156

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    NHGRI GWA Catalog
    Identification of genetic loci associated with Helicobacter pylori serologic status.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of toll-like receptor 6 (TLR6) in human B cells PubMed
    Envelope transmembrane glycoprotein gp41 env Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 gp41 increases IL-8 production PubMed
    env The HIV-1 gp41 transmembrane domain (TMD) inhibits the interaction between the TMDs of TLR2 and TLR6 in vitro PubMed
    capsid gag Exposure of the TLR2 transgene cell line, HEK293-TLR2/6, to HIV-1 CA (p24) increases IL-8 production BUT NOT in the TLR2 transgene cell lines, TZM-bl-2 and HEK293-TLR2/1 PubMed
    matrix gag Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 MA (p17) increases the production of IL-8 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
      Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing-Cross presentation, organism-specific biosystem (from REACTOME)
      Antigen processing-Cross presentation, organism-specific biosystemMHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment ...
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases associated with the TLR signaling cascade, organism-specific biosystem (from REACTOME)
      Diseases associated with the TLR signaling cascade, organism-specific biosystemToll like receptors (TLRs) are sensors of the innate immune system that detect danger signals derived from pathogens (pathogen-associated molecular patterns - PAMP) or damaged cells (damage-associate...
    • Diseases of Immune System, organism-specific biosystem (from REACTOME)
      Diseases of Immune System, organism-specific biosystemThe immune system is a complex network of the biological processes that provide defense mechanisms during infection or in response to an intrinsic danger signal. Compromised immune response may prese...
    • ER-Phagosome pathway, organism-specific biosystem (from REACTOME)
      ER-Phagosome pathway, organism-specific biosystemThe other TAP-dependent cross-presentation mechanism in phagocytes is the endoplasmic reticulum (ER)-phagosome model. Desjardins proposed that ER is recruited to the cell surface, where it fuses wit...
    • IRAK4 deficiency (TLR2/4), organism-specific biosystem (from REACTOME)
      IRAK4 deficiency (TLR2/4), organism-specific biosystemInterleukin-1 receptor-associated kinase 4 (IRAK4) is a serine/threonine kinase, that mediates activation of transcriptional factors such as NFkB and AP1 downstream of IL-1 receptors and all toll lik...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • MyD88 deficiency (TLR2/4), organism-specific biosystem (from REACTOME)
      MyD88 deficiency (TLR2/4), organism-specific biosystemMyeloid differentiation primary response (MyD88) is an adaptor protein that mediates intracellular signaling pathways evoked by all Toll-like receptors (TLRs) except for TLR3 and by several interleuk...
    • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Regulation of TLR by endogenous ligand, organism-specific biosystem (from REACTOME)
      Regulation of TLR by endogenous ligand, organism-specific biosystemDiverse molecules of host-cell origin may serve as endogenous ligands of Toll-like receptors (TLRs) (Erridge C 2010; Piccinini AM & Midwood KS 2010). These molecules are known as damage-associated mo...
    • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Regulation of toll-like receptor signaling pathway, organism-specific biosystem
      Regulation of toll-like receptor signaling pathway
    • Simplified Depiction of MYD88 Distinct Input-Output Pathway, organism-specific biosystem (from WikiPathways)
      Simplified Depiction of MYD88 Distinct Input-Output Pathway, organism-specific biosystemThis pathway is based on figure 7 from Li et al. Formation of MyD88 dimer catalyzes formation of IRAK1/TRAF6 complex. UEV1A and Ubc13 ubiquinate TRAF6 which allow for the activation of NFKB and AP-1 ...
    • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
    • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
      Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • Toll-like Receptor Signaling, organism-specific biosystem (from WikiPathways)
      Toll-like Receptor Signaling, organism-specific biosystemThis pathway is based on the figure 1 of "Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study" (see bibliography). TLR and NFkB are important in inflamma...
    • Toll-like Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Toll-like Receptor Signaling Pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Toll-like receptor 2 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Toll-like receptor 2 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    amyloid-beta binding IC
    Inferred by Curator
    more info
    PubMed 
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    lipopeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipopeptide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MyD88-dependent toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    MyD88-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    TRIF-dependent toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    activation of NF-kappaB-inducing kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to amyloid-beta IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to diacyl bacterial lipopeptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to diacyl bacterial lipopeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to oxidised low-density lipoprotein particle stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    defense response to bacterium TAS
    Traceable Author Statement
    more info
    PubMed 
    detection of diacyl bacterial lipopeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1 beta secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microglial cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-8 secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of toll-like receptor 2 signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    nitric oxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of NLRP3 inflammasome complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cytokine production involved in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-6 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of macrophage activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of oxidative stress-induced neuron death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of reactive oxygen species biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    toll-like receptor 6 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    toll-like receptor TLR6:TLR2 signaling pathway TAS
    Traceable Author Statement
    more info
     
    toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Toll-like receptor 2-Toll-like receptor 6 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    receptor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028087.1 RefSeqGene

      Range
      5001..38114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006068.4NP_006059.2  toll-like receptor 6 precursor

      See identical proteins and their annotated locations for NP_006059.2

      Status: REVIEWED

      Source sequence(s)
      AC108044, AK313618
      Consensus CDS
      CCDS3446.1
      UniProtKB/Swiss-Prot
      Q9Y2C9
      UniProtKB/TrEMBL
      B2R933
      Related
      ENSP00000389600.2, ENST00000436693.6
      Conserved Domains (7) summary
      smart00082
      Location:529582
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:641780
      TIR; Toll - interleukin 1 - resistance
      sd00031
      Location:5477
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:3653
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:76133
      LRR_8; Leucine rich repeat
      cl26018
      Location:43208
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:353565
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

      Range
      38823680..38857767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513614.3XP_011511916.1  toll-like receptor 6 isoform X1

      See identical proteins and their annotated locations for XP_011511916.1

      UniProtKB/Swiss-Prot
      Q9Y2C9
      Conserved Domains (7) summary
      smart00082
      Location:529582
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:641780
      TIR; Toll - interleukin 1 - resistance
      sd00031
      Location:5477
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:3653
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:76133
      LRR_8; Leucine rich repeat
      cl26018
      Location:43208
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:353565
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    2. XM_005262637.5XP_005262694.1  toll-like receptor 6 isoform X1

      See identical proteins and their annotated locations for XP_005262694.1

      UniProtKB/Swiss-Prot
      Q9Y2C9
      Conserved Domains (7) summary
      smart00082
      Location:529582
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:641780
      TIR; Toll - interleukin 1 - resistance
      sd00031
      Location:5477
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:3653
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:76133
      LRR_8; Leucine rich repeat
      cl26018
      Location:43208
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:353565
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    3. XM_011513613.3XP_011511915.1  toll-like receptor 6 isoform X1

      See identical proteins and their annotated locations for XP_011511915.1

      UniProtKB/Swiss-Prot
      Q9Y2C9
      Conserved Domains (7) summary
      smart00082
      Location:529582
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:641780
      TIR; Toll - interleukin 1 - resistance
      sd00031
      Location:5477
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:3653
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:76133
      LRR_8; Leucine rich repeat
      cl26018
      Location:43208
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:353565
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    4. XM_024453873.1XP_024309641.1  toll-like receptor 6 isoform X1

      Conserved Domains (7) summary
      smart00082
      Location:529582
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:641780
      TIR; Toll - interleukin 1 - resistance
      sd00031
      Location:5477
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:3653
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:76133
      LRR_8; Leucine rich repeat
      cl26018
      Location:43208
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:353565
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
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