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    TNIP1 TNFAIP3 interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 10318, updated on 13-Apr-2025

    Summary

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    Official Symbol
    TNIP1provided by HGNC
    Official Full Name
    TNFAIP3 interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:16903
    See related
    Ensembl:ENSG00000145901 MIM:607714; AllianceGenome:HGNC:16903
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VAN; NAF1; ABIN-1; nip40-1
    Summary
    This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Ubiquitous expression in fat (RPKM 55.9), spleen (RPKM 36.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TNIP1 in Genome Data Viewer
    Location:
    5q33.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (151029943..151087685, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (151566421..151624171, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150409504..150467246, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378228 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:150376236-150376402 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:150401597-150402796 Neighboring gene glutathione peroxidase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:150435866-150436392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23430 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:150445954-150446696 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:150446697-150447439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16518 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:150460705-150461415 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23435 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:150473600-150474799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23438 Neighboring gene annexin A6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:150503406-150503906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23443 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:150537501-150538357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23444 Neighboring gene uncharacterized LOC107986463 Neighboring gene platelet derived growth factor receptor like 2, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. [The role of TNIP1 in the pathogenesis of myasthenia gravis among patients with thymoma]. Geng Y, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2016 Oct. PMID 27577206
    2. TT genotype of rs10036748 in TNIP1 shows better response to methotrexate in a Chinese population: a prospective cohort study. Yan KX, et al. Br J Dermatol, 2019 Oct. PMID 31020648
    3. TNIP1-mediated TNF-α/NF-κB signalling cascade sustains glioma cell proliferation. Lei Q, et al. J Cell Mol Med, 2020 Jan. PMID 31691497, Free PMC Article
    4. Role of Systemic Lupus Erythematosus Risk Variants With Opposing Functional Effects as a Driver of Hypomorphic Expression of TNIP1 and Other Genes Within a Three-Dimensional Chromatin Network. Pasula S, et al. Arthritis Rheumatol, 2020 May. PMID 31804013, Free PMC Article
    5. TNIP1 in Autoimmune Diseases: Regulation of Toll-like Receptor Signaling. Shamilov R, et al. J Immunol Res, 2018. PMID 30402506, Free PMC Article

    See all (186) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3.
      Title: Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3.
    2. TNFAIP3-interacting protein 1 polymorphisms and their association with symptomatic human respiratory syncytial virus infection and bronchiolitis in infants younger than one year from South Africa: A case-control study.
      Title: TNFAIP3-interacting protein 1 polymorphisms and their association with symptomatic human respiratory syncytial virus infection and bronchiolitis in infants younger than one year from South Africa: A case-control study.
    3. The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR.
      Title: The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR.
    4. TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
      Title: TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
    5. TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.
      Title: TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.
    6. Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms.
      Title: Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms.
    7. ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis.
      Title: ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis.
    8. Assessment of the association between TNIP1 polymorphism with clinical features and risk of systemic lupus erythematosus.
      Title: Assessment of the association between TNIP1 polymorphism with clinical features and risk of systemic lupus erythematosus.
    9. Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1.
      Title: Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1.
    10. A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-kappaB signaling in activated T cells.
      Title: A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells.
    Submit: New GeneRIF Correction See all GeneRIFs (95)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
    EBI GWAS Catalog
    Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
    EBI GWAS Catalog
    Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
    EBI GWAS Catalog
    Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
    EBI GWAS Catalog
    Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Nef-associated factor 1 (Naf1) binds to HIV-1 Nef through amino acids 94-412 of Naf1; overexpression of Naf1 in 293T cells increases CD4 expression, and Nef suppresses this activity of Naf1 to downregulate CD4 PubMed
    matrix gag VAN is efficiently incorporated into HIV-1 virions, presumably as a result of binding to HIV-1 Matrix PubMed
    gag The C-terminus (amino acids 468-637) of virion-associated matrix-interacting protein (VAN) binds to HIV-1 Matrix and has been proposed to play a role in the nuclear import of the HIV-1 preintegration complex PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0113

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mitogen-activated protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitogen-activated protein kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in MyD88-dependent toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in glycoprotein biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukocyte cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of viral genome replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TNFAIP3-interacting protein 1
    Names
    A20-binding inhibitor of NF-kappa-B activation 1
    HIV-1 Nef-interacting protein
    Nef-associated factor 1 SNP
    virion-associated nuclear shuttling protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030590.1 RefSeqGene

      Range
      11627..62716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001252385.2 → NP_001239314.1  TNFAIP3-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001239314.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AB252973, AK074400, AK303573, AW589284
      Consensus CDS
      CCDS75359.1
      UniProtKB/TrEMBL
      A0A0A0MRZ4, B7Z8K2
      Related
      ENSP00000374029.3, ENST00000389378.6
      Conserved Domains (5) summary
      pfam15058
      Location:14 → 149
      Speriolin_N; Speriolin N terminus
      cd16269
      Location:367 → 379
      GBP_C; coiled coil [structural motif]
      cl15254
      Location:452 → 500
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      cl19252
      Location:214 → 251
      MreC; rod shape-determining protein MreC
      cl20817
      Location:298 → 399
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_001252386.2 → NP_001239315.1  TNFAIP3-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001239315.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains multiple differences in the coding region, compared to variant 1, one of which is the use of a downstream start codon. Isoform 2 has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB252975, AK074400, AW589284, BX640647
      Consensus CDS
      CCDS58982.1
      UniProtKB/TrEMBL
      B7Z5B0
      Related
      ENSP00000429891.1, ENST00000520931.5
      Conserved Domains (4) summary
      cd16269
      Location:314 → 326
      GBP_C; coiled coil [structural motif]
      cl15254
      Location:399 → 447
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      cl19252
      Location:161 → 198
      MreC; rod shape-determining protein MreC
      cl20817
      Location:245 → 346
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. NM_001252390.2 → NP_001239319.1  TNFAIP3-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001239319.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
      Source sequence(s)
      AB252970, AC008641, AK074400, AK290999, AW589284
      Consensus CDS
      CCDS34280.1
      UniProtKB/Swiss-Prot
      A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
      UniProtKB/TrEMBL
      A8K4N4
      Related
      ENSP00000428187.1, ENST00000522226.5
      Conserved Domains (2) summary
      cl19252
      Location:214 → 251
      MreC; rod shape-determining protein MreC
      cl25732
      Location:298 → 538
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_001252391.2 → NP_001239320.1  TNFAIP3-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001239320.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
      Source sequence(s)
      AB252970, AK074400, AW589284, DA643531
      Consensus CDS
      CCDS34280.1
      UniProtKB/Swiss-Prot
      A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
      UniProtKB/TrEMBL
      A8K4N4
      Related
      ENSP00000317891.7, ENST00000315050.11
      Conserved Domains (2) summary
      cl19252
      Location:214 → 251
      MreC; rod shape-determining protein MreC
      cl25732
      Location:298 → 538
      SMC_N; RecF/RecN/SMC N terminal domain

    5. NM_001252392.2 → NP_001239321.1  TNFAIP3-interacting protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001239321.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting isoform (4) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 6 and 7 encode the same protein (isoform 4).
      Source sequence(s)
      AB252971, AK074400, AW589284, DA643531
      Consensus CDS
      CCDS58985.1
      UniProtKB/TrEMBL
      A4F1Y0
      Related
      ENSP00000428243.1, ENST00000523338.5
      Conserved Domains (6) summary
      pfam15058
      Location:14 → 149
      Speriolin_N; Speriolin N terminus
      pfam15619
      Location:334 → 507
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cd16269
      Location:367 → 379
      GBP_C; coiled coil [structural motif]
      cl15254
      Location:452 → 500
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      cl19252
      Location:214 → 251
      MreC; rod shape-determining protein MreC
      cl20817
      Location:298 → 399
      GBP_C; Guanylate-binding protein, C-terminal domain

    6. NM_001252393.2 → NP_001239322.1  TNFAIP3-interacting protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001239322.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting isoform (4) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 6 and 7 encode the same protein (isoform 4).
      Source sequence(s)
      AB252973, AK074400, AW589284
      Consensus CDS
      CCDS58985.1
      UniProtKB/TrEMBL
      A4F1Y0
      Related
      ENSP00000430971.1, ENST00000518977.5
      Conserved Domains (6) summary
      pfam15058
      Location:14 → 149
      Speriolin_N; Speriolin N terminus
      pfam15619
      Location:334 → 507
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cd16269
      Location:367 → 379
      GBP_C; coiled coil [structural motif]
      cl15254
      Location:452 → 500
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      cl19252
      Location:214 → 251
      MreC; rod shape-determining protein MreC
      cl20817
      Location:298 → 399
      GBP_C; Guanylate-binding protein, C-terminal domain

    7. NM_001258454.2 → NP_001245383.1  TNFAIP3-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001245383.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
      Source sequence(s)
      AC008641
      Consensus CDS
      CCDS34280.1
      UniProtKB/Swiss-Prot
      A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
      UniProtKB/TrEMBL
      A8K4N4
      Conserved Domains (2) summary
      cl19252
      Location:214 → 251
      MreC; rod shape-determining protein MreC
      cl25732
      Location:298 → 538
      SMC_N; RecF/RecN/SMC N terminal domain

    8. NM_001258455.1 → NP_001245384.1  TNFAIP3-interacting protein 1 isoform 5

      See identical proteins and their annotated locations for NP_001245384.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks an exon and uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 5) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB177543, AC008641
      Consensus CDS
      CCDS58984.1
      UniProtKB/TrEMBL
      A8K4N4
      Related
      ENSP00000431105.1, ENST00000523200.5
      Conserved Domains (3) summary
      pfam15058
      Location:14 → 149
      Speriolin_N; Speriolin N terminus
      cl19252
      Location:214 → 251
      MreC; rod shape-determining protein MreC
      cl25732
      Location:298 → 529
      SMC_N; RecF/RecN/SMC N terminal domain

    9. NM_001258456.1 → NP_001245385.1  TNFAIP3-interacting protein 1 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks two exons in the 3' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 6) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB177544, AC008641
      Consensus CDS
      CCDS58983.1
      UniProtKB/TrEMBL
      E7EMV7
      Related
      ENSP00000429912.1, ENST00000524280.5
      Conserved Domains (6) summary
      pfam15058
      Location:14 → 149
      Speriolin_N; Speriolin N terminus
      cd16269
      Location:367 → 379
      GBP_C; coiled coil [structural motif]
      cl02415
      Location:323 → 365
      DUF922; Bacterial protein of unknown function (DUF922)
      cl15254
      Location:452 → 500
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      cl19252
      Location:214 → 251
      MreC; rod shape-determining protein MreC
      cl20817
      Location:298 → 399
      GBP_C; Guanylate-binding protein, C-terminal domain

    10. NM_001364486.2 → NP_001351415.1  TNFAIP3-interacting protein 1 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' and 3' UTRs and coding sequence and uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (7) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC008641
      UniProtKB/TrEMBL
      B7Z5B0
      Conserved Domains (2) summary
      cl19252
      Location:161 → 198
      MreC; rod shape-determining protein MreC
      cl25732
      Location:245 → 485
      SMC_N; RecF/RecN/SMC N terminal domain

    11. NM_001364487.2 → NP_001351416.1  TNFAIP3-interacting protein 1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) lacks an alternate in-frame exon and uses an alternate splice junction compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC008641
      Consensus CDS
      CCDS58984.1
      UniProtKB/TrEMBL
      A8K4N4
      Related
      ENSP00000483944.1, ENST00000610535.5
      Conserved Domains (3) summary
      pfam15058
      Location:14 → 149
      Speriolin_N; Speriolin N terminus
      cl19252
      Location:214 → 251
      MreC; rod shape-determining protein MreC
      cl25732
      Location:298 → 529
      SMC_N; RecF/RecN/SMC N terminal domain

    12. NM_001437734.1 → NP_001424663.1  TNFAIP3-interacting protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC008641

    13. NM_001437735.1 → NP_001424664.1  TNFAIP3-interacting protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC008641

    14. NM_001437736.1 → NP_001424665.1  TNFAIP3-interacting protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC008641

    15. NM_001437737.1 → NP_001424666.1  TNFAIP3-interacting protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC008641

    16. NM_001437738.1 → NP_001424667.1  TNFAIP3-interacting protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC008641

    17. NM_001437739.1 → NP_001424668.1  TNFAIP3-interacting protein 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC008641

    18. NM_001437740.1 → NP_001424669.1  TNFAIP3-interacting protein 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC008641

    19. NM_001437741.1 → NP_001424670.1  TNFAIP3-interacting protein 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC008641

    20. NM_001437742.1 → NP_001424671.1  TNFAIP3-interacting protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC008641

    21. NM_001437743.1 → NP_001424672.1  TNFAIP3-interacting protein 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC008641

    22. NM_001437744.1 → NP_001424673.1  TNFAIP3-interacting protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008641

    23. NM_001437745.1 → NP_001424674.1  TNFAIP3-interacting protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC008641

    24. NM_001437746.1 → NP_001424675.1  TNFAIP3-interacting protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC008641

    25. NM_001437747.1 → NP_001424676.1  TNFAIP3-interacting protein 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC008641

    26. NM_006058.5 → NP_006049.3  TNFAIP3-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_006049.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is longer and contains a distinct Cz-terminus, compared to isoform 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
      Source sequence(s)
      AB252972, AK074400, AW589284
      Consensus CDS
      CCDS34280.1
      UniProtKB/Swiss-Prot
      A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
      UniProtKB/TrEMBL
      A8K4N4
      Related
      ENSP00000430760.1, ENST00000521591.6
      Conserved Domains (2) summary
      cl19252
      Location:214 → 251
      MreC; rod shape-determining protein MreC
      cl25732
      Location:298 → 538
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      151029943..151087685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416627.1 → XP_047272583.1  TNFAIP3-interacting protein 1 isoform X8

      UniProtKB/TrEMBL
      E7EMV7
      Related
      ENSP00000427854.1, ENST00000519339.5

    2. XM_047416623.1 → XP_047272579.1  TNFAIP3-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      B7Z5B0
      Related
      ENSP00000428487.2, ENST00000522100.6

    3. XM_047416625.1 → XP_047272581.1  TNFAIP3-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      A8K4N4

    4. XM_047416615.1 → XP_047272571.1  TNFAIP3-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
      UniProtKB/TrEMBL
      A8K4N4
      Related
      ENSP00000430279.2, ENST00000520695.6

    5. XM_047416617.1 → XP_047272573.1  TNFAIP3-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
      UniProtKB/TrEMBL
      A8K4N4

    6. XM_047416616.1 → XP_047272572.1  TNFAIP3-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
      UniProtKB/TrEMBL
      A8K4N4

    7. XM_047416618.1 → XP_047272574.1  TNFAIP3-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
      UniProtKB/TrEMBL
      A8K4N4

    8. XM_047416626.1 → XP_047272582.1  TNFAIP3-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      A8K4N4

    9. XM_047416619.1 → XP_047272575.1  TNFAIP3-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
      UniProtKB/TrEMBL
      A8K4N4

    10. XM_047416624.1 → XP_047272580.1  TNFAIP3-interacting protein 1 isoform X5

      UniProtKB/TrEMBL
      B7Z5B0

    11. XM_047416622.1 → XP_047272578.1  TNFAIP3-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MRZ4, B7Z8K2

    12. XM_006714752.4 → XP_006714815.1  TNFAIP3-interacting protein 1 isoform X7

      UniProtKB/TrEMBL
      A4F1Y0
      Conserved Domains (5) summary
      pfam15058
      Location:14 → 149
      Speriolin_N; Speriolin N terminus
      cd16269
      Location:367 → 379
      GBP_C; coiled coil [structural motif]
      cl15254
      Location:452 → 500
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      cl19252
      Location:214 → 251
      MreC; rod shape-determining protein MreC
      cl20817
      Location:298 → 399
      GBP_C; Guanylate-binding protein, C-terminal domain

    13. XM_005268355.3 → XP_005268412.1  TNFAIP3-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MRZ4, B7Z8K2
      Conserved Domains (5) summary
      pfam15058
      Location:14 → 149
      Speriolin_N; Speriolin N terminus
      cd16269
      Location:367 → 379
      GBP_C; coiled coil [structural motif]
      cl15254
      Location:452 → 500
      UBAN; polyubiquitin binding domain of NEMO and related proteins
      cl19252
      Location:214 → 251
      MreC; rod shape-determining protein MreC
      cl20817
      Location:298 → 399
      GBP_C; Guanylate-binding protein, C-terminal domain

    14. XM_047416620.1 → XP_047272576.1  TNFAIP3-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A4F1Y0

    15. XM_047416621.1 → XP_047272577.1  TNFAIP3-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A4F1Y0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      151566421..151624171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351427.1 → XP_054207402.1  TNFAIP3-interacting protein 1 isoform X8

      UniProtKB/TrEMBL
      E7EMV7

    2. XM_054351422.1 → XP_054207397.1  TNFAIP3-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      B7Z5B0

    3. XM_054351424.1 → XP_054207399.1  TNFAIP3-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      A8K4N4

    4. XM_054351414.1 → XP_054207389.1  TNFAIP3-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
      UniProtKB/TrEMBL
      A8K4N4

    5. XM_054351416.1 → XP_054207391.1  TNFAIP3-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
      UniProtKB/TrEMBL
      A8K4N4

    6. XM_054351415.1 → XP_054207390.1  TNFAIP3-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
      UniProtKB/TrEMBL
      A8K4N4

    7. XM_054351425.1 → XP_054207400.1  TNFAIP3-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      A8K4N4

    8. XM_054351417.1 → XP_054207392.1  TNFAIP3-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
      UniProtKB/TrEMBL
      A8K4N4

    9. XM_054351423.1 → XP_054207398.1  TNFAIP3-interacting protein 1 isoform X5

      UniProtKB/TrEMBL
      B7Z5B0

    10. XM_054351421.1 → XP_054207396.1  TNFAIP3-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MRZ4, B7Z8K2

    11. XM_054351426.1 → XP_054207401.1  TNFAIP3-interacting protein 1 isoform X7

      UniProtKB/TrEMBL
      A4F1Y0

    12. XM_054351420.1 → XP_054207395.1  TNFAIP3-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MRZ4, B7Z8K2

    13. XM_054351418.1 → XP_054207393.1  TNFAIP3-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A4F1Y0

    14. XM_054351419.1 → XP_054207394.1  TNFAIP3-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A4F1Y0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15025.2 GenPept UniProtKB/Swiss-Prot:Q15025

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