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    DLEU1 deleted in lymphocytic leukemia 1 [ Homo sapiens (human) ]

    Gene ID: 10301, updated on 5-Aug-2018

    Summary

    Official Symbol
    DLEU1provided by HGNC
    Official Full Name
    deleted in lymphocytic leukemia 1provided by HGNC
    Primary source
    HGNC:HGNC:13747
    See related
    Ensembl:ENSG00000176124 MIM:605765; Vega:OTTHUMG00000016934
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCMS; DLB1; LEU1; LEU2; XTP6; BCMS1; DLEU2; LINC00021; NCRNA00021
    Expression
    Ubiquitous expression in testis (RPKM 1.6), colon (RPKM 1.5) and 25 other tissues See more

    Genomic context

    See DLEU1 in Genome Data Viewer
    Location:
    13q14.2-q14.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (50082169..50528643)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (50656414..50679433)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene deleted in lymphocytic leukemia 2 Neighboring gene microRNA 16-1 Neighboring gene microRNA 15a Neighboring gene ribosomal protein L18 pseudogene 10 Neighboring gene ST13, Hsp70 interacting protein pseudogene 4 Neighboring gene ribosomal protein L34 pseudogene 26 Neighboring gene DLEU1 antisense RNA 1 Neighboring gene uncharacterized LOC107984568 Neighboring gene uncharacterized LOC107984567 Neighboring gene deleted in lymphocytic leukemia 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog
    Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
    NHGRI GWA Catalog
    Genome-wide association study of lung function decline in adults with and without asthma.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
    NHGRI GWA Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • B-cell neoplasia-associated gene with multiple splicing
    • deleted in lymphocytic leukemia 1 (non-protein coding)
    • leukemia-associated protein 2
    • long intergenic non-protein coding RNA 21

    Clone Names

    • FLJ92453, MGC22430

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002605.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AL137060
    2. NR_109973.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AJ412024, AK095311, AL137060, DB444728
      Related
      ENST00000469754.2, OTTHUMT00000045001
    3. NR_109974.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon and contains multiple additional 3' terminal exons, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AJ412032, AJ412055, AL161424, DB444728
      Related
      ENST00000491615.5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      50082169..50528643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005887.1: Suppressed sequence

      Description
      NM_005887.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
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