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    RGS19 regulator of G protein signaling 19 [ Homo sapiens (human) ]

    Gene ID: 10287, updated on 12-Aug-2018
    Official Symbol
    RGS19provided by HGNC
    Official Full Name
    regulator of G protein signaling 19provided by HGNC
    Primary source
    HGNC:HGNC:13735
    See related
    Ensembl:ENSG00000171700 MIM:605071; Vega:OTTHUMG00000033024
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAIP; RGSGAIP
    Summary
    G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 8.6) and 21 other tissues See more
    Orthologs
    See RGS19 in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (64073181..64080004, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62704534..62711356, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene chromosome 20 open reading frame 204 Neighboring gene transcription elongation factor A2 Neighboring gene SOX18 promoter region Neighboring gene SRY-box 18 Neighboring gene microRNA 6813 Neighboring gene opioid related nociceptin receptor 1 Neighboring gene LKAAEAR motif containing 1 Neighboring gene neuropeptides B and W receptor 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • G alpha (z) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (z) signalling events, organism-specific biosystemThe heterotrimeric G protein Gz, is a member of the Gi family. Unlike other Gi family members it lacks an ADP ribosylation site cysteine four residues from the carboxyl terminus and is thus pertussis...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
      Neurotrophic factor-mediated Trk receptor signaling
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein alpha-subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    brush border IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with heterotrimeric G-protein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    regulator of G-protein signaling 19
    Names
    G alpha interacting protein
    G protein signalling regulator 19
    guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein
    regulator of G-protein signalling 19

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039467.1NP_001034556.1  regulator of G-protein signaling 19

      See identical proteins and their annotated locations for NP_001034556.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1.
      Source sequence(s)
      BC001318, BM554550
      Consensus CDS
      CCDS13555.1
      UniProtKB/Swiss-Prot
      P49795
      Related
      ENSP00000333194.5, OTTHUMP00000031632, ENST00000332298.9, OTTHUMT00000080273
      Conserved Domains (1) summary
      cd08745
      Location:87204
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
    2. NM_005873.2NP_005864.1  regulator of G-protein signaling 19

      See identical proteins and their annotated locations for NP_005864.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript.
      Source sequence(s)
      AF285097, BC063010
      Consensus CDS
      CCDS13555.1
      UniProtKB/Swiss-Prot
      P49795
      Related
      ENSP00000378483.1, ENST00000395042.1
      Conserved Domains (1) summary
      cd08745
      Location:87204
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

      Range
      64073181..64080004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260183.2XP_005260240.1  regulator of G-protein signaling 19 isoform X3

      See identical proteins and their annotated locations for XP_005260240.1

      UniProtKB/TrEMBL
      B4DP94
      Conserved Domains (1) summary
      cd08745
      Location:65182
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
    2. XM_005260182.3XP_005260239.1  regulator of G-protein signaling 19 isoform X3

      See identical proteins and their annotated locations for XP_005260239.1

      UniProtKB/TrEMBL
      B4DP94
      Conserved Domains (1) summary
      cd08745
      Location:65182
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
    3. XM_011528485.2XP_011526787.1  regulator of G-protein signaling 19 isoform X2

      See identical proteins and their annotated locations for XP_011526787.1

      UniProtKB/Swiss-Prot
      P49795
      Conserved Domains (1) summary
      cd08745
      Location:87204
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
    4. XM_011528484.2XP_011526786.1  regulator of G-protein signaling 19 isoform X1

      Conserved Domains (1) summary
      cd08745
      Location:116233
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
    5. XM_011528486.2XP_011526788.1  regulator of G-protein signaling 19 isoform X2

      See identical proteins and their annotated locations for XP_011526788.1

      UniProtKB/Swiss-Prot
      P49795
      Conserved Domains (1) summary
      cd08745
      Location:87204
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
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