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    MRPS31 mitochondrial ribosomal protein S31 [ Homo sapiens (human) ]

    Gene ID: 10240, updated on 5-Sep-2021


    Official Symbol
    MRPS31provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein S31provided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000102738 MIM:611992
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S31mt; IMOGN38; MRP-S31
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. [provided by RefSeq, Jul 2008]
    Ubiquitous expression in lymph node (RPKM 11.9), testis (RPKM 11.7) and 25 other tissues See more
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    Genomic context

    See MRPS31 in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (40729128..40771207, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (41303264..41345326, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene forkhead box O1 Neighboring gene ring finger protein, LIM domain interacting pseudogene 1 Neighboring gene microRNA 320d-1 Neighboring gene solute carrier family 25 member 15 Neighboring gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 5 Neighboring gene microRNA 621 Neighboring gene CYCS pseudogene 34

    Genomic regions, transcripts, and products


    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information



    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    part_of mitochondrial small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info

    General protein information

    Preferred Names
    28S ribosomal protein S31, mitochondrial
    imogen 38
    mitochondrial small ribosomal subunit protein mS31

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005830.4NP_005821.2  28S ribosomal protein S31, mitochondrial

      See identical proteins and their annotated locations for NP_005821.2

      Status: REVIEWED

      Source sequence(s)
      AI343737, AL355132, AV712217, BC010159, BC022045
      Consensus CDS
      ENSP00000315397.6, ENST00000323563.8
      Conserved Domains (1) summary
      MRP-S31; Mitochondrial 28S ribosomal protein S31

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly


    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      40729128..40771207 complement
      GenBank, FASTA, Sequence Viewer (Graphics)


    1. XR_001749454.2 RNA Sequence

    2. XR_001749453.2 RNA Sequence

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