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    TRIB1 tribbles pseudokinase 1 [ Homo sapiens (human) ]

    Gene ID: 10221, updated on 23-May-2018
    Official Symbol
    TRIB1provided by HGNC
    Official Full Name
    tribbles pseudokinase 1provided by HGNC
    Primary source
    HGNC:HGNC:16891
    See related
    Ensembl:ENSG00000173334 MIM:609461; Vega:OTTHUMG00000165007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C8FW; GIG2; TRB1; GIG-2; SKIP1; TRB-1
    Expression
    Broad expression in bone marrow (RPKM 87.7), liver (RPKM 53.0) and 20 other tissues See more
    Orthologs
    See TRIB1 in Genome Data Viewer
    Location:
    8q24.13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (125430290..125438405)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (126442563..126450647)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase Neighboring gene HNF1 motif-containing MPRA enhancer 31 Neighboring gene RNA, 7SL, cytoplasmic 329, pseudogene Neighboring gene uncharacterized LOC105375746 Neighboring gene uncharacterized LOC105375747

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
    NHGRI GWA Catalog
    A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
    NHGRI GWA Catalog
    Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.
    NHGRI GWA Catalog
    Biological, clinical and population relevance of 95 loci for blood lipids.
    NHGRI GWA Catalog
    Common variants at 30 loci contribute to polygenic dyslipidemia.
    NHGRI GWA Catalog
    Discovery and refinement of loci associated with lipid levels.
    NHGRI GWA Catalog
    Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
    NHGRI GWA Catalog
    Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
    NHGRI GWA Catalog
    Genome-wide association of lipid-lowering response to statins in combined study populations.
    NHGRI GWA Catalog
    Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
    NHGRI GWA Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
    NHGRI GWA Catalog
    Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
    NHGRI GWA Catalog
    Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT ATP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    mitogen-activated protein kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitogen-activated protein kinase kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein kinase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    ubiquitin-protein transferase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of DNA binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of lipopolysaccharide-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neutrophil differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of eosinophil differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of macrophage differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    NOT protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    tribbles homolog 1
    Names
    G-protein-coupled receptor induced protein
    G-protein-coupled receptor-induced gene 2 protein
    G-protein-coupled receptor-induced protein 2
    phosphoprotein regulated by mitogenic pathways
    tribbles-like protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282985.1NP_001269914.1  tribbles homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_001269914.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC091114, BC012441, DA686993
      Consensus CDS
      CCDS64971.1
      UniProtKB/Swiss-Prot
      Q96RU8
      Related
      ENSP00000429063.1, OTTHUMP00000228188, ENST00000520847.1, OTTHUMT00000381431
      Conserved Domains (2) summary
      smart00220
      Location:1172
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1172
      PKc_like; Protein Kinases, catalytic domain
    2. NM_025195.3NP_079471.1  tribbles homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_079471.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript nd encodes the longer isoform (1).
      Source sequence(s)
      AC091114, AL832388, BC012441
      Consensus CDS
      CCDS6357.1
      UniProtKB/Swiss-Prot
      Q96RU8
      Related
      ENSP00000312150.3, OTTHUMP00000228187, ENST00000311922.3, OTTHUMT00000381430
      Conserved Domains (1) summary
      cd14023
      Location:97338
      PK_TRB1; Pseudokinase domain of Tribbles Homolog 1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

      Range
      125430290..125438405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_428373.3 RNA Sequence

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