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    TRIM13 tripartite motif containing 13 [ Homo sapiens (human) ]

    Gene ID: 10206, updated on 8-Jul-2021

    Summary

    Official Symbol
    TRIM13provided by HGNC
    Official Full Name
    tripartite motif containing 13provided by HGNC
    Primary source
    HGNC:HGNC:9976
    See related
    Ensembl:ENSG00000204977 MIM:605661
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAR; LEU5; RFP2; DLEU5; RNF77
    Summary
    This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 17.7), bone marrow (RPKM 8.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TRIM13 in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (49997042..50018467)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (50571178..50592603)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene SPRY domain containing 7 Neighboring gene deleted in lymphocytic leukemia 2 Neighboring gene microRNA 3613 Neighboring gene potassium channel regulator Neighboring gene microRNA 16-1 Neighboring gene microRNA 15a

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity TAS
    Traceable Author Statement
    more info
     
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in endoplasmic reticulum mannose trimming TAS
    Traceable Author Statement
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of viral release from host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of viral transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of macroautophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to gamma radiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ubiquitin-dependent ERAD pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum quality control compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM13
    Names
    B-cell chronic lymphocytic leukemia tumor suppressor Leu5
    CLL-associated RING finger
    RING finger protein 77
    RING-type E3 ubiquitin transferase TRIM13
    leukemia-associated protein 5
    putative tumor suppressor RFP2
    ret finger protein 2
    tripartite motif protein 13
    tripartite motif-containing protein 13
    NP_001007279.1
    NP_005789.2
    NP_434698.1
    NP_998755.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007278.3NP_001007279.1  E3 ubiquitin-protein ligase TRIM13 isoform 2

      See identical proteins and their annotated locations for NP_001007279.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an additional internal exon, which contains an upstream in-frame AUG start codon compared to variant 1. The encoded protein (isoform 2) has a longer N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL832695, AY455758, AY764035, KF455768
      Consensus CDS
      CCDS41888.1
      UniProtKB/Swiss-Prot
      O60858
      UniProtKB/TrEMBL
      L7MTJ6
      Related
      ENSP00000348299.4, ENST00000356017.8
      Conserved Domains (2) summary
      smart00336
      Location:93134
      BBOX; B-Box-type zinc finger
      cd00162
      Location:1264
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_005798.5NP_005789.2  E3 ubiquitin-protein ligase TRIM13 isoform 1

      See identical proteins and their annotated locations for NP_005789.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the same protein (isoform 1) as variants 2 and 3.
      Source sequence(s)
      AF241850, AL832695, AY455758, BI668033, KF455768
      Consensus CDS
      CCDS9423.1
      UniProtKB/Swiss-Prot
      O60858
      UniProtKB/TrEMBL
      A0A024RDU3, L7MTJ6
      Related
      ENSP00000412943.2, ENST00000420995.6
      Conserved Domains (3) summary
      smart00336
      Location:90131
      BBOX; B-Box-type zinc finger
      pfam12252
      Location:163234
      SidE; Dot/Icm substrate protein
      cd16762
      Location:561
      RING-HC_TRIM13_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 13 (TRIM13) and similar proteins
    3. NM_052811.4NP_434698.1  E3 ubiquitin-protein ligase TRIM13 isoform 1

      See identical proteins and their annotated locations for NP_434698.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AL832695, AY191002, AY455758, BI668033, KF455768
      Consensus CDS
      CCDS9423.1
      UniProtKB/Swiss-Prot
      O60858
      UniProtKB/TrEMBL
      A0A024RDU3, L7MTJ6
      Related
      ENSP00000399206.2, ENST00000457662.2
      Conserved Domains (3) summary
      smart00336
      Location:90131
      BBOX; B-Box-type zinc finger
      pfam12252
      Location:163234
      SidE; Dot/Icm substrate protein
      cd16762
      Location:561
      RING-HC_TRIM13_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 13 (TRIM13) and similar proteins
    4. NM_213590.3NP_998755.1  E3 ubiquitin-protein ligase TRIM13 isoform 1

      See identical proteins and their annotated locations for NP_998755.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AL832695, AY455758, KF455768
      Consensus CDS
      CCDS9423.1
      UniProtKB/Swiss-Prot
      O60858
      UniProtKB/TrEMBL
      A0A024RDU3, L7MTJ6
      Related
      ENSP00000367424.3, ENST00000378182.4
      Conserved Domains (3) summary
      smart00336
      Location:90131
      BBOX; B-Box-type zinc finger
      pfam12252
      Location:163234
      SidE; Dot/Icm substrate protein
      cd16762
      Location:561
      RING-HC_TRIM13_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 13 (TRIM13) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      49997042..50018467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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