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    TNK2 tyrosine kinase non receptor 2 [ Homo sapiens (human) ]

    Gene ID: 10188, updated on 28-Nov-2021

    Summary

    Official Symbol
    TNK2provided by HGNC
    Official Full Name
    tyrosine kinase non receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:19297
    See related
    Ensembl:ENSG00000061938 MIM:606994
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACK; ACK1; ACK-1; p21cdc42Hs
    Summary
    This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 21.9), bone marrow (RPKM 14.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TNK2 in Genome Data Viewer
    Location:
    3q29
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (195863364..195908551, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195590235..195635422, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mucin 4, cell surface associated Neighboring gene Sharpr-MPRA regulatory region 430 Neighboring gene uncharacterized LOC107984010 Neighboring gene long intergenic non-protein coding RNA 1983 Neighboring gene kinesin family member 3A pseudogene 1 Neighboring gene microRNA 6829 Neighboring gene TNK2 antisense RNA 1 Neighboring gene serine/threonine-protein phosphatase 4 regulatory subunit 2-like Neighboring gene RNA, U2 small nuclear 11, pseudogene Neighboring gene mucin-5AC-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ44758, FLJ45547

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables WW domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables epidermal growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine/tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Grb2-EGFR complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoophidium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    activated CDC42 kinase 1
    Names
    activated Cdc42-associated kinase 1
    activated p21cdc42Hs kinase
    tyrosine kinase non-receptor protein 2
    NP_001010938.2
    NP_001294975.1
    NP_001369200.1
    NP_001369201.1
    NP_001369202.1
    NP_001369203.1
    NP_001369204.1
    NP_001373093.1
    NP_001374636.1
    NP_001374637.1
    NP_001374638.1
    NP_001374639.1
    NP_001374640.1
    NP_001374641.1
    NP_001374642.1
    NP_001374643.1
    NP_001374644.1
    NP_001374645.1
    NP_001374646.1
    NP_001374647.1
    NP_001374648.1
    NP_001374649.1
    NP_001374650.1
    NP_005772.3
    XP_005269331.1
    XP_005269332.1
    XP_011510619.1
    XP_011510620.2
    XP_011510623.1
    XP_016860998.1
    XP_024309059.1
    XP_024309060.1
    XP_024309061.1
    XP_024309062.1
    XP_024309063.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029779.1 RefSeqGene

      Range
      5001..50645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001010938.2NP_001010938.2  activated CDC42 kinase 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a distinct 5' UTR and 5' coding region, lacks one alternate 3' coding exon, and contains a different alternate 3' coding exon, as compared to variant 1. The translation remains in-frame, and results in a longer isoform (2) that has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK127455, AK131539, BC020395, L13738
      Consensus CDS
      CCDS33927.1
      Related
      ENSP00000499858.1, ENST00000671753.1
      Conserved Domains (7) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:582888
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:9981037
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
      pfam09027
      Location:471538
      GTPase_binding; GTPase binding
      pfam11555
      Location:813877
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
    2. NM_001308046.2NP_001294975.1  activated CDC42 kinase 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate 5' exon, contains an alternate 5' terminal exon, lacks one alternate 3' coding exon, and initiates translation at an alternate start codon, compared to variant 1. It encodes a shorter isoform (3) that has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS77875.1
      UniProtKB/Swiss-Prot
      Q07912
      UniProtKB/TrEMBL
      C9J1X3
      Related
      ENSP00000392546.1, ENST00000428187.7
      Conserved Domains (7) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:158417
      STYKc; Protein kinase; unclassified specificity
      cd14328
      Location:9911030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    3. NM_001382271.1NP_001369200.1  activated CDC42 kinase 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Related
      ENSP00000503221.1, ENST00000678220.1
      Conserved Domains (8) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:575881
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9931036
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10231062
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    4. NM_001382272.1NP_001369201.1  activated CDC42 kinase 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (8) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:582888
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:10001043
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10301069
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473538
      GTPase_binding; GTPase binding
      pfam11555
      Location:813877
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
    5. NM_001382273.1NP_001369202.1  activated CDC42 kinase 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Related
      ENSP00000499899.1, ENST00000672887.2
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9761019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10061045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    6. NM_001382274.1NP_001369203.1  activated CDC42 kinase 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9761019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10061045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    7. NM_001382275.1NP_001369204.1  activated CDC42 kinase 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (7) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:590896
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:10061045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    8. NM_001386164.1NP_001373093.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Related
      ENSP00000500887.1, ENST00000673420.1
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9611004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9911030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    9. NM_001387707.1NP_001374636.1  activated CDC42 kinase 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (8) summary
      cd09539
      Location:3899
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:590896
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:10081051
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10381077
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427476
      SH3_9; Variant SH3 domain
    10. NM_001387708.1NP_001374637.1  activated CDC42 kinase 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (8) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:567873
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9851028
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10151054
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473538
      GTPase_binding; GTPase binding
      pfam11555
      Location:798862
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
    11. NM_001387709.1NP_001374638.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9611004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9911030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    12. NM_001387710.1NP_001374639.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9611004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9911030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    13. NM_001387711.1NP_001374640.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9611004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9911030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    14. NM_001387712.1NP_001374641.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9611004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9911030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    15. NM_001387713.1NP_001374642.1  activated CDC42 kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9581002
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9891028
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    16. NM_001387714.1NP_001374643.1  activated CDC42 kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9581002
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9891028
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    17. NM_001387715.1NP_001374644.1  activated CDC42 kinase 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (7) summary
      cd09539
      Location:3091
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:567873
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:9831022
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473538
      GTPase_binding; GTPase binding
      pfam11555
      Location:798862
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419468
      SH3_9; Variant SH3 domain
    18. NM_001387716.1NP_001374645.1  activated CDC42 kinase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (7) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:9741013
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    19. NM_001387717.1NP_001374646.1  activated CDC42 kinase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (7) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:9741013
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    20. NM_001387718.1NP_001374647.1  activated CDC42 kinase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (7) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:9741013
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    21. NM_001387719.1NP_001374648.1  activated CDC42 kinase 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (7) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:959998
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    22. NM_001387720.1NP_001374649.1  activated CDC42 kinase 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Related
      ENSP00000500486.1, ENST00000672024.1
      Conserved Domains (7) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:959998
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    23. NM_001387721.1NP_001374650.1  activated CDC42 kinase 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Conserved Domains (7) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:959998
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    24. NM_005781.5NP_005772.3  activated CDC42 kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_005772.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the more frequently occurring transcript and it encodes isoform 1.
      Source sequence(s)
      AC124944, AK127455, AK131539, BG742978, CN411136, L13738
      Consensus CDS
      CCDS33928.1
      UniProtKB/Swiss-Prot
      Q07912
      UniProtKB/TrEMBL
      B3KXJ4
      Related
      ENSP00000329425.6, ENST00000333602.14
      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9581002
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:9891028
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain

    RNA

    1. NR_170678.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    2. NR_170679.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    3. NR_170680.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    4. NR_170681.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    5. NR_170682.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    6. NR_170683.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    7. NR_170684.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    8. NR_170685.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    9. NR_170686.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    10. NR_170687.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    11. NR_170688.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    12. NR_170689.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    13. NR_170690.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    14. NR_170691.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944
    15. NR_170692.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      195863364..195908551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453292.1XP_024309060.1  activated CDC42 kinase 1 isoform X8

      Conserved Domains (6) summary
      cd09539
      Location:2384
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:410461
      SH3; Src homology 3 domains
      PHA03247
      Location:575881
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9931036
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10231062
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:147404
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    2. XM_024453295.1XP_024309063.1  activated CDC42 kinase 1 isoform X9

      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9761019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10061045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    3. XM_024453291.1XP_024309059.1  activated CDC42 kinase 1 isoform X6

      Conserved Domains (8) summary
      cd09539
      Location:70131
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      cd14274
      Location:10401083
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10701109
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:194451
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam14604
      Location:459508
      SH3_9; Variant SH3 domain
      pfam09027
      Location:511578
      GTPase_binding; GTPase binding
      pfam11555
      Location:853917
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      cl26464
      Location:622928
      Atrophin-1; Atrophin-1 family
    4. XM_011512317.3XP_011510619.1  activated CDC42 kinase 1 isoform X1

      Conserved Domains (8) summary
      cd09539
      Location:170231
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:290549
      STYKc; Protein kinase; unclassified specificity
      cd14274
      Location:11401183
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:11701209
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:294551
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:611678
      GTPase_binding; GTPase binding
      pfam11555
      Location:9531017
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:559608
      SH3_9; Variant SH3 domain
    5. XM_005269275.3XP_005269332.1  activated CDC42 kinase 1 isoform X12

      Conserved Domains (6) summary
      cd14274
      Location:662705
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:692731
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      pfam09027
      Location:133200
      GTPase_binding; GTPase binding
      pfam11555
      Location:475539
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:81130
      SH3_9; Variant SH3 domain
      cl21453
      Location:173
      PKc_like; Protein Kinases, catalytic domain
    6. XM_011512318.2XP_011510620.2  activated CDC42 kinase 1 isoform X2

    7. XM_024453293.1XP_024309061.1  activated CDC42 kinase 1 isoform X9

      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9761019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10061045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    8. XM_024453294.1XP_024309062.1  activated CDC42 kinase 1 isoform X9

      Conserved Domains (8) summary
      cd09539
      Location:667
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558864
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:9761019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:10061045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395444
      SH3_9; Variant SH3 domain
    9. XM_011512321.2XP_011510623.1  activated CDC42 kinase 1 isoform X10

      Conserved Domains (7) summary
      smart00221
      Location:50309
      STYKc; Protein kinase; unclassified specificity
      cd14274
      Location:900943
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:930969
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:54311
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:371438
      GTPase_binding; GTPase binding
      pfam11555
      Location:713777
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:319368
      SH3_9; Variant SH3 domain
    10. XM_005269274.3XP_005269331.1  activated CDC42 kinase 1 isoform X11

      Conserved Domains (6) summary
      cd14274
      Location:737780
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:767806
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      pfam09027
      Location:208275
      GTPase_binding; GTPase binding
      pfam11555
      Location:550614
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:156205
      SH3_9; Variant SH3 domain
      cl21453
      Location:1148
      PKc_like; Protein Kinases, catalytic domain
    11. XM_017005509.1XP_016860998.1  activated CDC42 kinase 1 isoform X4

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