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    LPAR6 lysophosphatidic acid receptor 6 [ Homo sapiens (human) ]

    Gene ID: 10161, updated on 12-Jan-2019

    Summary

    Official Symbol
    LPAR6provided by HGNC
    Official Full Name
    lysophosphatidic acid receptor 6provided by HGNC
    Primary source
    HGNC:HGNC:15520
    See related
    Ensembl:ENSG00000139679 MIM:609239
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LAH3; P2Y5; ARWH1; HYPT8; P2RY5
    Summary
    The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
    Expression
    Ubiquitous expression in placenta (RPKM 27.8), fat (RPKM 19.3) and 24 other tissues See more
    Orthologs

    Genomic context

    See LPAR6 in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (48400897..48444704, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (48985181..49018840, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RB transcriptional corepressor 1 Neighboring gene PEST containing nuclear protein pseudogene 5 Neighboring gene uncharacterized LOC112268118 Neighboring gene RCC1 and BTB domain containing protein 2 Neighboring gene uncharacterized LOC105370201

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Nucleotide GPCRs, organism-specific biosystem (from WikiPathways)
      Nucleotide GPCRs, organism-specific biosystem
      Nucleotide GPCRs
    • Nucleotide-like (purinergic) receptors, organism-specific biosystem (from REACTOME)
      Nucleotide-like (purinergic) receptors, organism-specific biosystemPurinergic receptors (Burnstock G, 2006; Abbracchio MP et al, 2009) are a family of newly characterized plasma membrane molecules involved in several cellular functions such as vascular reactivity, a...
    • P2Y receptors, organism-specific biosystem (from REACTOME)
      P2Y receptors, organism-specific biosystemP2Y receptors are a family of purinergic receptors, G protein-coupled receptors stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in hum...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
      Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
      Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC120358

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    lysophosphatidic acid receptor 6
    Names
    G-protein coupled purinergic receptor P2Y5
    LPA receptor 6
    LPA-6
    P2Y purinoceptor 5
    RB intron encoded G-protein coupled receptor
    oleoyl-L-alpha-lysophosphatidic acid receptor
    purinergic receptor 5
    purinergic receptor P2Y G protein-coupled protein 5
    purinergic receptor P2Y, G-protein coupled, 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012874.1 RefSeqGene

      Range
      5001..38660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001162497.1NP_001155969.1  lysophosphatidic acid receptor 6

      See identical proteins and their annotated locations for NP_001155969.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK122856, AK123059, BX647109
      Consensus CDS
      CCDS9410.1
      UniProtKB/Swiss-Prot
      P43657
      UniProtKB/TrEMBL
      A0A024RDT2, B3KVQ5
      Related
      ENSP00000344353.2, ENST00000345941.2
      Conserved Domains (1) summary
      cd15156
      Location:18302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001162498.1NP_001155970.1  lysophosphatidic acid receptor 6

      See identical proteins and their annotated locations for NP_001155970.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK123059, BC040850, BF950635, BF951153, BX647109
      Consensus CDS
      CCDS9410.1
      UniProtKB/Swiss-Prot
      P43657
      UniProtKB/TrEMBL
      A0A024RDT2, B3KVQ5
      Conserved Domains (1) summary
      cd15156
      Location:18302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_005767.5NP_005758.2  lysophosphatidic acid receptor 6

      See identical proteins and their annotated locations for NP_005758.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK123059, BC045651, BX647109
      Consensus CDS
      CCDS9410.1
      UniProtKB/Swiss-Prot
      P43657
      UniProtKB/TrEMBL
      A0A024RDT2, B3KVQ5
      Related
      ENSP00000367691.3, ENST00000378434.8
      Conserved Domains (1) summary
      cd15156
      Location:18302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      48400897..48444704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449304.1XP_024305072.1  lysophosphatidic acid receptor 6 isoform X3

    2. XM_024449303.1XP_024305071.1  lysophosphatidic acid receptor 6 isoform X2

    3. XM_024449302.1XP_024305070.1  lysophosphatidic acid receptor 6 isoform X1

      Related
      ENSP00000482660.1, ENST00000620633.4
      Conserved Domains (1) summary
      cd15156
      Location:18302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
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