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    LPAR6 lysophosphatidic acid receptor 6 [ Homo sapiens (human) ]

    Gene ID: 10161, updated on 5-Dec-2021

    Summary

    Official Symbol
    LPAR6provided by HGNC
    Official Full Name
    lysophosphatidic acid receptor 6provided by HGNC
    Primary source
    HGNC:HGNC:15520
    See related
    Ensembl:ENSG00000139679 MIM:609239
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LAH3; P2Y5; ARWH1; HYPT8; LPA-6; P2RY5
    Summary
    The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
    Expression
    Ubiquitous expression in placenta (RPKM 27.8), fat (RPKM 19.3) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LPAR6 in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (48400897..48444669, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (48985274..49018805, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RB transcriptional corepressor 1 Neighboring gene PEST containing nuclear protein pseudogene 5 Neighboring gene uncharacterized LOC112268118 Neighboring gene RCC1 and BTB domain containing protein 2 Neighboring gene long intergenic non-protein coding RNA 1077 Neighboring gene long intergenic non-protein coding RNA 462

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC120358

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lysophosphatidic acid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    lysophosphatidic acid receptor 6
    Names
    G-protein coupled purinergic receptor P2Y5
    LPA receptor 6
    P2Y purinoceptor 5
    RB intron encoded G-protein coupled receptor
    oleoyl-L-alpha-lysophosphatidic acid receptor
    purinergic receptor 5
    purinergic receptor P2Y G protein-coupled protein 5
    purinergic receptor P2Y, G-protein coupled, 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012874.1 RefSeqGene

      Range
      5036..38660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001162497.3NP_001155969.1  lysophosphatidic acid receptor 6

      See identical proteins and their annotated locations for NP_001155969.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AL136960, AL392048
      Consensus CDS
      CCDS9410.1
      UniProtKB/Swiss-Prot
      P43657
      UniProtKB/TrEMBL
      A0A024RDT2, B3KVQ5
      Related
      ENSP00000344353.2, ENST00000345941.2
      Conserved Domains (1) summary
      cd15156
      Location:18302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001162498.3NP_001155970.1  lysophosphatidic acid receptor 6

      See identical proteins and their annotated locations for NP_001155970.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AL392048
      Consensus CDS
      CCDS9410.1
      UniProtKB/Swiss-Prot
      P43657
      UniProtKB/TrEMBL
      A0A024RDT2, B3KVQ5
      Related
      ENSP00000482660.1, ENST00000620633.5
      Conserved Domains (1) summary
      cd15156
      Location:18302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001377316.2NP_001364245.1  lysophosphatidic acid receptor 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AL136960, AL392048
      Conserved Domains (1) summary
      cd15156
      Location:18302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_001377317.2NP_001364246.1  lysophosphatidic acid receptor 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AL136960, AL392048
      Conserved Domains (1) summary
      cd15156
      Location:18302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    5. NM_005767.7NP_005758.2  lysophosphatidic acid receptor 6

      See identical proteins and their annotated locations for NP_005758.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AL136960, AL392048
      Consensus CDS
      CCDS9410.1
      UniProtKB/Swiss-Prot
      P43657
      UniProtKB/TrEMBL
      A0A024RDT2, B3KVQ5
      Related
      ENSP00000367691.3, ENST00000378434.8
      Conserved Domains (1) summary
      cd15156
      Location:18302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      48400897..48444669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449304.1XP_024305072.1  lysophosphatidic acid receptor 6 isoform X3

    2. XM_024449303.1XP_024305071.1  lysophosphatidic acid receptor 6 isoform X2

    3. XM_024449302.1XP_024305070.1  lysophosphatidic acid receptor 6 isoform X1

      Conserved Domains (1) summary
      cd15156
      Location:18302
      7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
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