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    ARPC2 actin related protein 2/3 complex subunit 2 [ Homo sapiens (human) ]

    Gene ID: 10109, updated on 12-Aug-2018
    Official Symbol
    ARPC2provided by HGNC
    Official Full Name
    actin related protein 2/3 complex subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:705
    See related
    Ensembl:ENSG00000163466 MIM:604224; Vega:OTTHUMG00000133618
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARC34; PRO2446; p34-Arc; PNAS-139
    Summary
    This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 92.4), bone marrow (RPKM 89.6) and 25 other tissues See more
    Orthologs
    See ARPC2 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (218217094..218254348)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219081817..219119071)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine receptor 1 Neighboring gene high mobility group box 1 pseudogene 9 Neighboring gene uncharacterized LOC101928487 Neighboring gene transfer RNA-Tyr (ATA) 1-1 Neighboring gene G protein-coupled bile acid receptor 1 Neighboring gene angio associated migratory cell protein

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env M-tropic HIV-1 gp120 enhances the binding of WASp and the actin-related protein 2/3 complex with beta-actin, an interaction essential for the proper formation of podosomes in immature monocyte-derived dendritic cells PubMed
    env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced association of LSP1, Wiskott-Aldrich Syndrome protein (WASp), Actin-Related Protein 2/3 (Arp2/3), and beta-actin in immature monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

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    • CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CDC42 signaling events, organism-specific biosystem
      CDC42 signaling events
    • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
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      EPHB-mediated forward signaling, organism-specific biosystemMultiple EPHB receptors contribute directly to dendritic spine development and morphogenesis. These are more broadly involved in post-synaptic development through activation of focal adhesion kinase ...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
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    • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
      ErbB1 downstream signaling, organism-specific biosystem
      ErbB1 downstream signaling
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    • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
      Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
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      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
      Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
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    • Pathogenic Escherichia coli infection, organism-specific biosystem (from WikiPathways)
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      RAC1 signaling pathway, organism-specific biosystem
      RAC1 signaling pathway
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases Activate WASPs and WAVEs, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate WASPs and WAVEs, organism-specific biosystemWASP and WAVE proteins belong to the Wiskott-Aldrich Syndrome protein family, with recessive mutations in the founding member WASP being responsible for the X-linked recessive immunodeficieny known a...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    structural constituent of cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    actin polymerization-dependent cell motility TAS
    Traceable Author Statement
    more info
    PubMed 
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    membrane organization TAS
    Traceable Author Statement
    more info
     
    positive regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Arp2/3 protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    focal adhesion HDA PubMed 
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    muscle cell projection membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    actin-related protein 2/3 complex subunit 2
    Names
    ARP2/3 protein complex subunit 34
    actin related protein 2/3 complex, subunit 2, 34kDa
    arp2/3 complex 34 kDa subunit
    testis tissue sperm-binding protein Li 53e

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005731.3NP_005722.1  actin-related protein 2/3 complex subunit 2

      See identical proteins and their annotated locations for NP_005722.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AF006085, CN291458
      Consensus CDS
      CCDS2410.1
      UniProtKB/Swiss-Prot
      O15144
      UniProtKB/TrEMBL
      Q53R19
      Related
      ENSP00000295685.10, OTTHUMP00000164144, ENST00000295685.14, OTTHUMT00000256777
      Conserved Domains (1) summary
      pfam04045
      Location:57284
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
    2. NM_152862.2NP_690601.1  actin-related protein 2/3 complex subunit 2

      See identical proteins and their annotated locations for NP_690601.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK290268, BG282181, CN291458
      Consensus CDS
      CCDS2410.1
      UniProtKB/Swiss-Prot
      O15144
      UniProtKB/TrEMBL
      Q53R19
      Related
      ENSP00000327137.5, OTTHUMP00000165866, ENST00000315717.9, OTTHUMT00000259038
      Conserved Domains (1) summary
      pfam04045
      Location:57284
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      218217094..218254348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017003113.1XP_016858602.1  actin-related protein 2/3 complex subunit 2 isoform X1

      Conserved Domains (1) summary
      pfam04045
      Location:2229
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
    2. XM_017003114.1XP_016858603.1  actin-related protein 2/3 complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A024R408
      Conserved Domains (1) summary
      pfam04045
      Location:1170
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
    3. XM_017003115.2XP_016858604.1  actin-related protein 2/3 complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A024R408
      Conserved Domains (1) summary
      pfam04045
      Location:1170
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
    4. XM_024452509.1XP_024308277.1  actin-related protein 2/3 complex subunit 2 isoform X2

      Conserved Domains (1) summary
      pfam04045
      Location:1170
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
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