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    ARPC3 actin related protein 2/3 complex subunit 3 [ Homo sapiens (human) ]

    Gene ID: 10094, updated on 10-Oct-2020

    Summary

    Official Symbol
    ARPC3provided by HGNC
    Official Full Name
    actin related protein 2/3 complex subunit 3provided by HGNC
    Primary source
    HGNC:HGNC:706
    See related
    Ensembl:ENSG00000111229 MIM:604225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARC21; p21-Arc
    Summary
    This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
    Expression
    Ubiquitous expression in lymph node (RPKM 232.8), bone marrow (RPKM 231.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See ARPC3 in Genome Data Viewer
    Location:
    12q24.11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (110434823..110450337, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (110872695..110888222, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 7 Neighboring gene high mobility group AT-hook 1 pseudogene 3 Neighboring gene GPN-loop GTPase 3 Neighboring gene ribosomal protein L31 pseudogene 49 Neighboring gene family with sequence similarity 216 member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    actin polymerization-dependent cell motility TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    membrane organization TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Arp2/3 protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    filamentous actin IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion HDA PubMed 
    growth cone leading edge IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane HDA PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    actin-related protein 2/3 complex subunit 3
    Names
    ARP2/3 protein complex subunit p21
    actin related protein 2/3 complex, subunit 3, 21kDa
    arp2/3 complex 21 kDa subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278556.2NP_001265485.1  actin-related protein 2/3 complex subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_001265485.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1)
      Source sequence(s)
      AC144548, AI144468, BC067747, BF434378
      Consensus CDS
      CCDS9146.1
      UniProtKB/Swiss-Prot
      O15145
      Related
      ENSP00000228825.7, ENST00000228825.12
      Conserved Domains (1) summary
      pfam04062
      Location:1173
      P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit
    2. NM_001287222.2NP_001274151.1  actin-related protein 2/3 complex subunit 3 isoform 2

      See identical proteins and their annotated locations for NP_001274151.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the 3' coding region compared to variant 1. The resulting shorter isoform (2) lacks 1 aa compared to isoform 1.
      Source sequence(s)
      AC144548, AI144468, BC078162, BF434378, BG620669
      UniProtKB/Swiss-Prot
      O15145
      Conserved Domains (1) summary
      pfam04062
      Location:1172
      P21-Arc; ARP2/3 complex ARPC3 (21 kDa) subunit

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      110434823..110450337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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