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MRC2 mannose receptor C type 2 [ Homo sapiens (human) ]

Gene ID: 9902, updated on 15-Apr-2019

Summary

Official Symbol
MRC2provided by HGNC
Official Full Name
mannose receptor C type 2provided by HGNC
Primary source
HGNC:HGNC:16875
See related
Ensembl:ENSG00000011028 MIM:612264
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD280; UPARAP; CLEC13E; ENDO180
Summary
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in gall bladder (RPKM 26.1), ovary (RPKM 24.7) and 24 other tissues See more
Orthologs

Genomic context

See MRC2 in Genome Data Viewer
Location:
17q23.2
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (62627401..62693601)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (60704762..60770962)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tousled like kinase 2 Neighboring gene ribosomal protein S10 pseudogene 26 Neighboring gene uncharacterized LOC112268202 Neighboring gene uncharacterized LOC107985020 Neighboring gene RNA, U6 small nuclear 446, pseudogene Neighboring gene uncharacterized LOC105371855 Neighboring gene membrane associated ring-CH-type finger 10 Neighboring gene uncharacterized LOC101927877

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binds to mannose receptor on vaginal epithelial cells PubMed
env Mannose receptor (MR) dimers bind to soluble monomeric and trimeric HIV envelope and to HIV virion in capture assay PubMed
env Recombinant HIV-1 gp120 blocks Mannose Receptor-mediated phagocytosis in human and murine macrophages and microglial cells PubMed
env HIV-1 gp120 binds to B cells through mannose C-type lectin receptors (MCLRs), such as DC-SIGN, mannose receptor, and langerin PubMed
env HIV-1 gp120 interaction with human mannose receptor (hMR) results in increased production of matrix metalloproteinase-2 (MMP-2) in astrocytes PubMed
Tat tat HIV-1 Tat represses transcription from the rat mannose receptor promoter, thereby downregulating expression of mannose receptor PubMed
tat HIV-1 Tat interaction with cyclin T1 is required for the repression of mannose receptor (MR) and bone morphogenetic protein receptor-2 (BMPR2) promoters PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing-Cross presentation, organism-specific biosystem (from REACTOME)
    Antigen processing-Cross presentation, organism-specific biosystemMHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Cross-presentation of soluble exogenous antigens (endosomes), organism-specific biosystem (from REACTOME)
    Cross-presentation of soluble exogenous antigens (endosomes), organism-specific biosystemExogenous soluble antigens are cross-presented by dendritic cells, albeit with lower efficiency than for particulate substrates. Soluble antigens destined for cross-presentation are taken up by disti...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35911, KIAA0709

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
collagen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation HDA PubMed 
Component Evidence Code Pubs
focal adhesion HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
C-type mannose receptor 2
Names
C-type lectin domain family 13 member E
UPAR-associated protein
endocytic receptor (macrophage mannose receptor family)
endocytic receptor 180
macrophage mannose receptor 2
urokinase-type plasminogen activator receptor-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033955.1 RefSeqGene

    Range
    5001..71201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006039.5NP_006030.2  C-type mannose receptor 2 precursor

    See identical proteins and their annotated locations for NP_006030.2

    Status: REVIEWED

    Source sequence(s)
    AI458446, BC032763, BC146647, BC153884
    Consensus CDS
    CCDS11634.1
    UniProtKB/Swiss-Prot
    Q9UBG0
    Related
    ENSP00000307513.5, ENST00000303375.10
    Conserved Domains (5) summary
    smart00059
    Location:180228
    FN2; Fibronectin type 2 domain
    cd00037
    Location:247361
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:382505
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:46161
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:43127
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    62627401..62693601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525543.2XP_011523845.1  C-type mannose receptor 2 isoform X1

    Conserved Domains (5) summary
    smart00059
    Location:180228
    FN2; Fibronectin type 2 domain
    cd00037
    Location:247361
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:382505
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:46161
    RICIN; Ricin-type beta-trefoil
    cd00161
    Location:43127
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

RNA

  1. XR_934628.2 RNA Sequence

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