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CD151 CD151 molecule (Raph blood group) [ Homo sapiens (human) ]

Gene ID: 977, updated on 3-Dec-2024

Summary

Official Symbol
CD151provided by HGNC
Official Full Name
CD151 molecule (Raph blood group)provided by HGNC
Primary source
HGNC:HGNC:1630
See related
Ensembl:ENSG00000177697 MIM:602243; AllianceGenome:HGNC:1630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EBS7; GP27; MER2; RAPH; SFA1; PETA-3; TSPAN24
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 188.8), lung (RPKM 142.9) and 25 other tissues See more
Orthologs
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Genomic context

See CD151 in Genome Data Viewer
Location:
11p15.5
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (832952..838831)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (884376..890206)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (832952..838831)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11801 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4287 Neighboring gene patatin like phospholipase domain containing 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:827342-827880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:828421-828958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:828959-829498 Neighboring gene calcium release activated channel regulator 2B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:829499-830036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:831115-831654 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:831655-832192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3041 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:834349-834888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:837986-838960 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:840788-841532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:841533-842278 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:842279-843022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3045 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:843356-843524 Neighboring gene RNA polymerase II, I and III subunit L Neighboring gene tetraspanin 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:854507-855020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:858925-859458 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:859459-859992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:859993-860525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:860526-861060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:863729-864262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:865863-866396

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Epidermolysis bullosa simplex 7, with nephropathy and deafness
MedGen: C1836823 OMIM: 609057 GeneReviews: Epidermolysis Bullosa Simplex
not available
RAPH BLOOD GROUP SYSTEM
MedGen: C1867341 OMIM: 179620 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Downregulation of guanine nucleotide-releasing protein, CD151/PETA-3, neuronatin, neuroendocrine differentiation factor, mitochondria 16s rRNA, and signal recognition particle is observed in HIV-1 infected and HIV-1 gp120-treated astrocytes PubMed
Nef nef HIV-1 Nef downregulates the cell surface expression of CD151 (TSPAN24) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in focal adhesion HDA PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CD151 antigen
Names
CD151 antigen (Raph blood group)
hemidesmosomal tetraspanin CD151
membrane glycoprotein SFA-1
platelet surface glycoprotein gp27
platelet-endothelial cell tetraspan antigen 3
platelet-endothelial tetraspan antigen 3
tetraspanin-24
tspan-24

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007478.1 RefSeqGene

    Range
    5001..10880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_817

mRNA and Protein(s)

  1. NM_001039490.2NP_001034579.1  CD151 antigen

    See identical proteins and their annotated locations for NP_001034579.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate segment of sequence in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK130369, AU099249, BC001374, BQ957432
    Consensus CDS
    CCDS7719.1
    UniProtKB/Swiss-Prot
    A8KAK8, E9PI15, P48509, Q14826, Q86U54, Q96TE3
    UniProtKB/TrEMBL
    A0A6M5CDG2, A0A6M5CH24, A0A6M5CII8, Q53FU5
    Conserved Domains (2) summary
    cd03155
    Location:112220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:16244
    Tetraspannin; Tetraspanin family
  2. NM_004357.5NP_004348.2  CD151 antigen

    See identical proteins and their annotated locations for NP_004348.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AK130369, AU099249, BC001374
    Consensus CDS
    CCDS7719.1
    UniProtKB/Swiss-Prot
    A8KAK8, E9PI15, P48509, Q14826, Q86U54, Q96TE3
    UniProtKB/TrEMBL
    A0A6M5CDG2, A0A6M5CH24, A0A6M5CII8, Q53FU5
    Related
    ENSP00000380565.3, ENST00000397420.9
    Conserved Domains (2) summary
    cd03155
    Location:112220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:16244
    Tetraspannin; Tetraspanin family
  3. NM_139029.2NP_620598.1  CD151 antigen

    See identical proteins and their annotated locations for NP_620598.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK130369, AU099249, BC001374, BC013302
    Consensus CDS
    CCDS7719.1
    UniProtKB/Swiss-Prot
    A8KAK8, E9PI15, P48509, Q14826, Q86U54, Q96TE3
    UniProtKB/TrEMBL
    A0A6M5CDG2, A0A6M5CH24, A0A6M5CII8, Q53FU5
    Related
    ENSP00000324101.4, ENST00000322008.9
    Conserved Domains (2) summary
    cd03155
    Location:112220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:16244
    Tetraspannin; Tetraspanin family
  4. NM_139030.4NP_620599.1  CD151 antigen

    See identical proteins and their annotated locations for NP_620599.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK130369, AU099249, BC001374
    Consensus CDS
    CCDS7719.1
    UniProtKB/Swiss-Prot
    A8KAK8, E9PI15, P48509, Q14826, Q86U54, Q96TE3
    UniProtKB/TrEMBL
    A0A6M5CDG2, A0A6M5CH24, A0A6M5CII8, Q53FU5
    Related
    ENSP00000380566.1, ENST00000397421.5
    Conserved Domains (2) summary
    cd03155
    Location:112220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:16244
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    832952..838831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448780.2XP_024304548.1  CD151 antigen isoform X1

    UniProtKB/Swiss-Prot
    A8KAK8, E9PI15, P48509, Q14826, Q86U54, Q96TE3
    UniProtKB/TrEMBL
    A0A6M5CDG2, A0A6M5CH24, A0A6M5CII8, Q53FU5
    Conserved Domains (2) summary
    cd03155
    Location:112220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:16244
    Tetraspannin; Tetraspanin family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    884376..890206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370634.1XP_054226609.1  CD151 antigen isoform X1

    UniProtKB/Swiss-Prot
    A8KAK8, E9PI15, P48509, Q14826, Q86U54, Q96TE3
    UniProtKB/TrEMBL
    A0A6M5CDG2, A0A6M5CH24, A0A6M5CII8, Q53FU5