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ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 [ Homo sapiens (human) ]

Gene ID: 953, updated on 27-Nov-2024

Summary

Official Symbol
ENTPD1provided by HGNC
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 1provided by HGNC
Primary source
HGNC:HGNC:3363
See related
Ensembl:ENSG00000138185 MIM:601752; AllianceGenome:HGNC:3363
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD39; SPG64; ATP-DPH; ATPDase; NTPDase-1
Summary
The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in urinary bladder (RPKM 6.1), appendix (RPKM 5.8) and 24 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See ENTPD1 in Genome Data Viewer
Location:
10q24.1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (95694186..95877266)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (96573293..96756364)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (97471521..97637023)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3716 Neighboring gene aldehyde dehydrogenase 18 family member A1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3801 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:97454143-97454644 Neighboring gene tectonic family member 3 Neighboring gene MPRA-validated peak1056 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2650 Neighboring gene ENTPD1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3809 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3811 Neighboring gene Sharpr-MPRA regulatory region 13404 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:97645298-97645457 Neighboring gene MPRA-validated peak1059 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3813 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3814 Neighboring gene coiled-coil and C2 domain containing 2B Neighboring gene ribosomal protein L21 pseudogene 90 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:97786197-97787396 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:97802729-97802923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2652 Neighboring gene cyclin J

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ40921, FLJ40959, DKFZp686D194, DKFZp686I093

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
 
enables CDP phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables CTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables IDP phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables ITPase activity IEA
Inferred from Electronic Annotation
more info
 
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables apyrase activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
 
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
 
enables membrane scission GTPase motor activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleoside diphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ribonucleoside triphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ribonucleoside triphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in blood coagulation TAS
Traceable Author Statement
more info
PubMed 
involved_in cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleoside diphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ectonucleoside triphosphate diphosphohydrolase 1
Names
ATP diphosphohydrolase
CD39 antigen
NTPDase1
ecto-ATP diphosphohydrolase 1
ecto-ATPDase 1
ecto-ATPase 1
ecto-apyrase
lymphoid cell activation antigen
nucleoside triphosphate diphosphohydrolase 1
NP_001091645.1
NP_001157650.1
NP_001157651.1
NP_001157653.1
NP_001157654.1
NP_001157655.1
NP_001299583.1
NP_001307845.1
NP_001767.3
XP_011538672.3
XP_011538673.1
XP_011538674.3
XP_011538675.3
XP_011538676.3
XP_011538678.3
XP_016872447.1
XP_016872452.1
XP_016872453.1
XP_047281979.1
XP_047281980.1
XP_047281981.1
XP_047281982.1
XP_047281983.1
XP_047281984.1
XP_047281985.1
XP_054223180.1
XP_054223181.1
XP_054223182.1
XP_054223183.1
XP_054223184.1
XP_054223185.1
XP_054223186.1
XP_054223187.1
XP_054223188.1
XP_054223189.1
XP_054223190.1
XP_054223191.1
XP_054223192.1
XP_054223193.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042803.2 RefSeqGene

    Range
    66979..188082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001098175.2NP_001091645.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 2

    See identical proteins and their annotated locations for NP_001091645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon that results in a distinct 5' UTR and causes translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AJ133133, AL356632, AL365273
    Consensus CDS
    CCDS41554.1
    UniProtKB/Swiss-Prot
    P49961
    Related
    ENSP00000390955.2, ENST00000453258.6
    Conserved Domains (1) summary
    pfam01150
    Location:47478
    GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
  2. NM_001164178.1NP_001157650.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 3

    See identical proteins and their annotated locations for NP_001157650.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon that results in a distinct 5' UTR and causes translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK301459, AK304018, AL365273, CD652289
    Consensus CDS
    CCDS53556.1
    UniProtKB/Swiss-Prot
    P49961
    Related
    ENSP00000360250.3, ENST00000371207.8
    Conserved Domains (1) summary
    pfam01150
    Location:52483
    GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
  3. NM_001164179.2NP_001157651.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AL365273, AL547722
    Conserved Domains (1) summary
    pfam01150
    Location:40430
    GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
  4. NM_001164181.1NP_001157653.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 5

    See identical proteins and their annotated locations for NP_001157653.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in place of the first exon and lacks an alternate internal exon compared to variant 1, that results in a distinct 5' UTR and translation initiation at a downstream start codon. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1. Both variants 5 and 8 encode the same isoform (5).
    Source sequence(s)
    AK304018, AK316009, AL365273, CD652289
    Consensus CDS
    CCDS53557.1
    UniProtKB/Swiss-Prot
    P49961
    Related
    ENSP00000442968.1, ENST00000543964.6
    Conserved Domains (1) summary
    cl17037
    Location:1363
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  5. NM_001164182.2NP_001157654.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 6

    See identical proteins and their annotated locations for NP_001157654.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon that results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1. Both variants 6 and 7 encode the same isoform (6).
    Source sequence(s)
    AK304836, AL365273
    UniProtKB/Swiss-Prot
    P49961
    Conserved Domains (1) summary
    cl17037
    Location:1333
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  6. NM_001164183.2NP_001157655.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 6

    See identical proteins and their annotated locations for NP_001157655.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two alternate internal exons that results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1. Both variants 6 and 7 encode the same isoform (6).
    Source sequence(s)
    AL365273, BC047664, DC423382
    UniProtKB/Swiss-Prot
    P49961
    Conserved Domains (1) summary
    cl17037
    Location:1333
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  7. NM_001312654.1NP_001299583.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains two alternate exons in place of the first two exons compared to variant 1, that results in a distinct 5' UTR and translation initiation at a downstream start codon. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1. Both variants 5 and 8 encode the same isoform (5).
    Source sequence(s)
    AK298648, AL365273
    Consensus CDS
    CCDS53557.1
    UniProtKB/Swiss-Prot
    P49961
    Conserved Domains (1) summary
    cl17037
    Location:1363
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  8. NM_001320916.1NP_001307845.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AA748419, AK301459, BU852091, CD652289
    UniProtKB/Swiss-Prot
    P49961
    Conserved Domains (1) summary
    pfam01150
    Location:52454
    GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
  9. NM_001776.6NP_001767.3  ectonucleoside triphosphate diphosphohydrolase 1 isoform 1

    See identical proteins and their annotated locations for NP_001767.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AK304018, AL365273
    Consensus CDS
    CCDS7444.1
    UniProtKB/Swiss-Prot
    A9Z1X8, B4DWB9, B4E1X1, B7Z599, G3XAF6, P49961, Q5T561, Q5T562, Q86VV3, Q9UQQ9, Q9Y3Q9
    Related
    ENSP00000360248.4, ENST00000371205.5
    Conserved Domains (1) summary
    pfam01150
    Location:40471
    GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    95694186..95877266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426023.1XP_047281979.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

  2. XM_047426024.1XP_047281980.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

  3. XM_011540371.3XP_011538673.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

    See identical proteins and their annotated locations for XP_011538673.1

    UniProtKB/Swiss-Prot
    P49961
    Conserved Domains (1) summary
    pfam01150
    Location:47478
    GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
  4. XM_047426025.1XP_047281981.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

  5. XM_047426026.1XP_047281982.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

  6. XM_047426027.1XP_047281983.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X5

  7. XM_047426028.1XP_047281984.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X8

  8. XM_017016963.2XP_016872452.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X11

  9. XM_017016958.3XP_016872447.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X6

  10. XM_011540370.3XP_011538672.3  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

  11. XM_011540372.3XP_011538674.3  ectonucleoside triphosphate diphosphohydrolase 1 isoform X3

  12. XM_011540373.3XP_011538675.3  ectonucleoside triphosphate diphosphohydrolase 1 isoform X4

  13. XM_011540374.4XP_011538676.3  ectonucleoside triphosphate diphosphohydrolase 1 isoform X7

  14. XM_047426029.1XP_047281985.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X9

  15. XM_011540376.3XP_011538678.3  ectonucleoside triphosphate diphosphohydrolase 1 isoform X10

  16. XM_017016964.3XP_016872453.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X12

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    96573293..96756364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367206.1XP_054223181.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

  2. XM_054367207.1XP_054223182.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

  3. XM_054367208.1XP_054223183.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

  4. XM_054367211.1XP_054223186.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X5

  5. XM_054367214.1XP_054223189.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X8

  6. XM_054367217.1XP_054223192.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X11

  7. XM_054367212.1XP_054223187.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X6

  8. XM_054367210.1XP_054223185.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X4

  9. XM_054367205.1XP_054223180.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

  10. XM_054367209.1XP_054223184.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X3

  11. XM_054367213.1XP_054223188.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X7

  12. XM_054367215.1XP_054223190.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X9

  13. XM_054367216.1XP_054223191.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X10

  14. XM_054367218.1XP_054223193.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X12