Format

Send to:

Choose Destination

SCARB1 scavenger receptor class B member 1 [ Homo sapiens (human) ]

Gene ID: 949, updated on 21-Apr-2019

Summary

Official Symbol
SCARB1provided by HGNC
Official Full Name
scavenger receptor class B member 1provided by HGNC
Primary source
HGNC:HGNC:1664
See related
Ensembl:ENSG00000073060 MIM:601040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6
Summary
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2019]
Expression
Biased expression in adrenal (RPKM 333.6), placenta (RPKM 91.6) and 4 other tissues See more
Orthologs

Genomic context

See SCARB1 in Genome Data Viewer
Location:
12q24.31
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (124777628..124863973, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (125262174..125348519, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor corepressor 2 Neighboring gene uncharacterized LOC105370047 Neighboring gene uncharacterized LOC101927436 Neighboring gene uncharacterized LOC105370050 Neighboring gene uncharacterized LOC107984444 Neighboring gene uncharacterized LOC105370051 Neighboring gene RNA, U6 small nuclear 927, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
High density lipoprotein cholesterol level quantitative trait locus 6
MedGen: C1853096 OMIM: 610762 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
NHGRI GWA Catalog
Genome-wide association study identifies common variants associated with circulating vitamin E levels.
NHGRI GWA Catalog
Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
NHGRI GWA Catalog
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SCARB1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
    Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
    Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Bile secretion, organism-specific biosystem (from KEGG)
    Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Bile secretion, conserved biosystem (from KEGG)
    Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
    Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
  • Fat digestion and absorption, organism-specific biosystem (from KEGG)
    Fat digestion and absorption, organism-specific biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
  • Fat digestion and absorption, conserved biosystem (from KEGG)
    Fat digestion and absorption, conserved biosystemFat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, die...
  • Folate Metabolism, organism-specific biosystem (from WikiPathways)
    Folate Metabolism, organism-specific biosystem
    Folate Metabolism
  • HDL-mediated lipid transport, organism-specific biosystem (from REACTOME)
    HDL-mediated lipid transport, organism-specific biosystemHDL particles play a central role in the reverse transport of cholesterol, the process by which cholesterol in tissues other than the liver is returned to the liver for conversion to bile salts and e...
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
    Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
  • Lipoprotein metabolism, organism-specific biosystem (from REACTOME)
    Lipoprotein metabolism, organism-specific biosystemBecause of their hydrophobicity, lipids are found in the extracellular spaces of the human body primarily in the form of lipoprotein complexes. Chylomicrons form in the small intestine and transport ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Ovarian steroidogenesis, organism-specific biosystem (from KEGG)
    Ovarian steroidogenesis, organism-specific biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
  • Ovarian steroidogenesis, conserved biosystem (from KEGG)
    Ovarian steroidogenesis, conserved biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Scavenging by Class B Receptors, organism-specific biosystem (from REACTOME)
    Scavenging by Class B Receptors, organism-specific biosystemClass B receptors have two transmembrane domains separated by an extracellular loop (reviewed in Adachi and Tsujimoto 2006, Areschoug and Gordon 2009).
  • Selenium Micronutrient Network, organism-specific biosystem (from WikiPathways)
    Selenium Micronutrient Network, organism-specific biosystem
    Selenium Micronutrient Network
  • Statin Pathway, organism-specific biosystem (from WikiPathways)
    Statin Pathway, organism-specific biosystemStatins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in...
  • Sterol Regulatory Element-Binding Proteins (SREBP) signalling, organism-specific biosystem (from WikiPathways)
    Sterol Regulatory Element-Binding Proteins (SREBP) signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • Vitamin A and Carotenoid Metabolism, organism-specific biosystem (from WikiPathways)
    Vitamin A and Carotenoid Metabolism, organism-specific biosystemThis pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some ...
  • Vitamin B12 Metabolism, organism-specific biosystem (from WikiPathways)
    Vitamin B12 Metabolism, organism-specific biosystem
    Vitamin B12 Metabolism
  • Vitamin digestion and absorption, organism-specific biosystem (from KEGG)
    Vitamin digestion and absorption, organism-specific biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...
  • Vitamin digestion and absorption, conserved biosystem (from KEGG)
    Vitamin digestion and absorption, conserved biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138242

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol binding TAS
Traceable Author Statement
more info
PubMed 
amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 
apolipoprotein A-I binding IPI
Inferred from Physical Interaction
more info
PubMed 
apolipoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
high-density lipoprotein particle binding IEA
Inferred from Electronic Annotation
more info
 
high-density lipoprotein particle receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
high-density lipoprotein particle receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
scavenger receptor activity TAS
Traceable Author Statement
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adhesion of symbiont to host IMP
Inferred from Mutant Phenotype
more info
PubMed 
androgen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
cholesterol catabolic process IEA
Inferred from Electronic Annotation
more info
 
cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cholesterol import IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol import ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
detection of lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
high-density lipoprotein particle clearance IDA
Inferred from Direct Assay
more info
PubMed 
high-density lipoprotein particle clearance TAS
Traceable Author Statement
more info
 
high-density lipoprotein particle remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
intestinal absorption IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide transport IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cholesterol storage IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration TAS
Traceable Author Statement
more info
PubMed 
positive regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
recognition of apoptotic cell IDA
Inferred from Direct Assay
more info
PubMed 
regulation of phagocytosis IC
Inferred by Curator
more info
PubMed 
regulation of phosphatidylcholine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
reverse cholesterol transport IEP
Inferred from Expression Pattern
more info
PubMed 
triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
vitamin transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
caveola TAS
Traceable Author Statement
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosomal membrane HDA PubMed 
microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
scavenger receptor class B member 1
Names
CD36 and LIMPII analogous 1
CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
scavenger receptor class B type III

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028199.1 RefSeqGene

    Range
    5001..91346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001082959.2NP_001076428.1  scavenger receptor class B member 1 isoform 2

    See identical proteins and their annotated locations for NP_001076428.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC073593, AC126309
    Consensus CDS
    CCDS45008.1
    UniProtKB/Swiss-Prot
    Q8WTV0
    Related
    ENSP00000343795.4, ENST00000339570.9
    Conserved Domains (1) summary
    pfam01130
    Location:18446
    CD36; CD36 family
  2. NM_001367981.1NP_001354910.1  scavenger receptor class B member 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC073593, AC126309, BC022087
  3. NM_001367982.1NP_001354911.1  scavenger receptor class B member 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309, AK124112
  4. NM_001367983.1NP_001354912.1  scavenger receptor class B member 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  5. NM_001367984.1NP_001354913.1  scavenger receptor class B member 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  6. NM_001367985.1NP_001354914.1  scavenger receptor class B member 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  7. NM_001367986.1NP_001354915.1  scavenger receptor class B member 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309, BC143319
  8. NM_001367987.1NP_001354916.1  scavenger receptor class B member 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  9. NM_001367988.1NP_001354917.1  scavenger receptor class B member 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  10. NM_001367989.1NP_001354918.1  scavenger receptor class B member 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC073593, AC126309
  11. NM_005505.5NP_005496.4  scavenger receptor class B member 1 isoform 1

    See identical proteins and their annotated locations for NP_005496.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 13 both encode the same isoform (1).
    Source sequence(s)
    AC073593, BC080647, BG770204, CA428516
    Consensus CDS
    CCDS9259.1
    UniProtKB/Swiss-Prot
    Q8WTV0
    UniProtKB/TrEMBL
    A0A024RBS4
    Related
    ENSP00000261693.6, ENST00000261693.11
    Conserved Domains (1) summary
    pfam01130
    Location:18446
    CD36; CD36 family

RNA

  1. NR_160416.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  2. NR_160417.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  3. NR_160418.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  4. NR_160419.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  5. NR_160420.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  6. NR_160421.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  7. NR_160422.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  8. NR_160423.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309
  9. NR_160424.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073593, AC126309

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    124777628..124863973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center