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SLC25A27 solute carrier family 25 member 27 [ Homo sapiens (human) ]

Gene ID: 9481, updated on 3-Mar-2026
Official Symbol
SLC25A27provided by HGNC
Official Full Name
solute carrier family 25 member 27provided by HGNC
Primary source
HGNC:HGNC:21065
See related
Ensembl:ENSG00000153291 MIM:613725; AllianceGenome:HGNC:21065
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UCP4
Summary
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Expression
Broad expression in brain (RPKM 13.5), ovary (RPKM 8.8) and 22 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SLC25A27 in Genome Data Viewer
Location:
6p12.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (46652975..46678190)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (46490625..46515839)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (46620712..46645927)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17271 Neighboring gene RCAN2 divergent transcript Neighboring gene cytochrome P450 family 39 subfamily A member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:46542802-46543302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:46543303-46543803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24654 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17273 Neighboring gene TDRD6 and SLC25A27 antisense RNA 1 Neighboring gene tudor domain containing 6 Neighboring gene phospholipase A2 group VII Neighboring gene ankyrin repeat domain 66

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells. Chan SL, et al. J Biol Chem, 2006 Dec 8. PMID 17035241
  2. Mitochondrial UCP4 attenuates MPP+ - and dopamine-induced oxidative stress, mitochondrial depolarization, and ATP deficiency in neurons and is interlinked with UCP2 expression. Chu AC, et al. Free Radic Biol Med, 2009 Mar 15. PMID 19150400
  3. Uncoupling protein 4 (UCP4) gene variability in neurodegenerative disorders: further evidence of association in Frontotemporal dementia. Montesanto A, et al. Aging (Albany NY), 2018 Nov 13. PMID 30425186, Free PMC Article
  4. A homozygous genetic variant of mitochondrial uncoupling protein 4 exerts protection against the occurrence of multiple sclerosis. Szolnoki Z, et al. Neuromolecular Med, 2009. PMID 19536655
  5. Transcriptional regulation of UCP4 by NF-kappaB and its role in mediating protection against MPP+ toxicity. Ho JW, et al. Free Radic Biol Med, 2010 Jul 15. PMID 20385226

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study evaluated the occurrence of a variant of UCP4 in patients with frontotemporal dementia, Parkinson disease, and healthy controls.
    Title: Uncoupling protein 4 (UCP4) gene variability in neurodegenerative disorders: further evidence of association in Frontotemporal dementia.
  2. our results suggested DJ-1 might regulate the expression of UCP4 by oxidation of DJ-1 and partially via NF-kappaB pathway in its protective response to oxidative stress
    Title: Parkinson's disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress.
  3. This study found that the variability of UCP4 does affect the individual susceptibility to Late-Onset Alzheimer's Disease.
    Title: The Genetic Variability of UCP4 Affects the Individual Susceptibility to Late-Onset Alzheimer's Disease and Modifies the Disease's Risk in APOE-ɛ4 Carriers.
  4. Compares and contrasts all the known human SLC25A* genes and includes functional information.
    Title: The mitochondrial transporter family SLC25: identification, properties and physiopathology.
  5. UCP4 is a target effector gene of the NF-kappaB c-Rel prosurvival pathway to mitigate the effects of oxidative stress.
    Title: UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress.
  6. Neuronal UCP4 exhibits transmembrane chloride transport activity.
    Title: Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5.
  7. Findings show how UCP4 overexpression increases ATP synthesis by specifically interacting with Complex II.
    Title: Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells.
  8. UCP4 expression correlated with lymph node metastases, positive estrogen/progesterone receptor expression, and positivity for p53 and Ki-67 in breast carcinomas.
    Title: Mitochondrial UCP4 and bcl-2 expression in imprints of breast carcinomas: relationship with DNA ploidy and classical prognostic factors.
  9. A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis.(
    Title: A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis.
  10. the association found between the ultra-resistant schizophrenia group and the UCP4 haplotype is noteworthy as it may influence treatment outcome in schizophrenia.
    Title: Association of an UCP4 (SLC25A27) haplotype with ultra-resistant schizophrenia.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Replication interactions

Interaction Pubs
Knockdown of solute carrier family 25, member 27 (SLC25A27) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ33552

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chloride transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables proton transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in inner ear development IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular triglyceride homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mitochondrial calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of D-glucose import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cold IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
mitochondrial uncoupling protein 4
Names
UCP 4
uncoupling protein 4

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204051.2 → NP_001190980.1  mitochondrial uncoupling protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001190980.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK295233, AL591242, BC033091, BP310559
    UniProtKB/TrEMBL
    B4DHR4
    Conserved Domains (1) summary
    pfam00153
    Location:125 → 219
    Mito_carr; Mitochondrial carrier protein

  2. NM_001204052.2 → NP_001190981.1  mitochondrial uncoupling protein 4 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 3' UTR, compared to variant 1. The encoded protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL591242, BC033091, BP310559, DR002070
    Consensus CDS
    CCDS56431.1
    UniProtKB/Swiss-Prot
    O95847
    Related
    ENSP00000412024.2, ENST00000411689.6
    Conserved Domains (1) summary
    pfam00153
    Location:123 → 219
    Mito_carr; Mitochondrial carrier protein

  3. NM_004277.5 → NP_004268.3  mitochondrial uncoupling protein 4 isoform 1

    See identical proteins and their annotated locations for NP_004268.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF110532, AL591242, DA144842
    Consensus CDS
    CCDS43470.1
    UniProtKB/Swiss-Prot
    F5GWR4, O95847, Q5VTS9, Q8N518
    Related
    ENSP00000360398.3, ENST00000371347.10
    Conserved Domains (1) summary
    pfam00153
    Location:125 → 219
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    46652975..46678190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249483.3 → XP_005249540.1  mitochondrial uncoupling protein 4 isoform X1

    Conserved Domains (1) summary
    pfam00153
    Location:125 → 219
    Mito_carr; Mitochondrial carrier protein

  2. XM_047419575.1 → XP_047275531.1  mitochondrial uncoupling protein 4 isoform X2

    UniProtKB/TrEMBL
    B4DZG4, C9J0T3

RNA

  1. XR_007059387.1 RNA Sequence

  2. XR_007059388.1 RNA Sequence

  3. XR_007059389.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    46490625..46515839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356852.1 → XP_054212827.1  mitochondrial uncoupling protein 4 isoform X1

  2. XM_054356853.1 → XP_054212828.1  mitochondrial uncoupling protein 4 isoform X2

    UniProtKB/TrEMBL
    B4DZG4, C9J0T3

RNA

  1. XR_008487509.1 RNA Sequence

  2. XR_008487510.1 RNA Sequence

  3. XR_008487511.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95847.1 GenPept UniProtKB/Swiss-Prot:O95847

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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