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CD27 CD27 molecule [ Homo sapiens (human) ]

Gene ID: 939, updated on 10-Dec-2024

Summary

Official Symbol
CD27provided by HGNC
Official Full Name
CD27 moleculeprovided by HGNC
Primary source
HGNC:HGNC:11922
See related
Ensembl:ENSG00000139193 MIM:186711; AllianceGenome:HGNC:11922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T14; S152; Tp55; TNFRSF7; S152. LPFS2
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 38.5), spleen (RPKM 21.6) and 14 other tissues See more
Orthologs
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Genomic context

See CD27 in Genome Data Viewer
Location:
12p13.31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (6443892..6451713)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (6454276..6462105)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6553058..6560879)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5851 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5853 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:6543574-6544074 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4161 Neighboring gene CD27 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4162 Neighboring gene SRP14 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6554257-6554758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5859 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5861 Neighboring gene TAP binding protein like Neighboring gene vesicle associated membrane protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4165 Neighboring gene plakophilin 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD27 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of CD27molecule (TNFRSF7: tumor necrosis factor receptor superfamily, member 7) in human B cells PubMed
env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp140 upregulates the expression of the B cell activation marker CD38 and the memory B cell marker CD27 PubMed
Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD27 (TNFRSF7) PubMed
Tat tat HIV-1 Tat upregulates the expression of CD27 in stimulated CD8+T lymphocytes PubMed
Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD27 (TNFRSF7) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC20393

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in CD27 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adaptive immune memory response involving T cells and B cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immunoglobulin mediated immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of T cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of B cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of non-canonical NF-kappaB signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CD27 antigen
Names
CD27L receptor
T cell activation antigen S152
T-cell activation antigen CD27
tumor necrosis factor receptor superfamily, member 7

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031995.1 RefSeqGene

    Range
    5001..11834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_357

mRNA and Protein(s)

  1. NM_001242.5NP_001233.2  CD27 antigen isoform b precursor

    Status: REVIEWED

    Source sequence(s)
    AC005840
    Consensus CDS
    CCDS8545.1
    UniProtKB/Swiss-Prot
    B2RDZ0, P26842
    Related
    ENSP00000266557.3, ENST00000266557.4
    Conserved Domains (1) summary
    cd13408
    Location:4124
    TNFRSF7; Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), also known as CD27
  2. NM_001413263.1NP_001400192.1  CD27 antigen isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC005840
  3. NM_001413264.1NP_001400193.1  CD27 antigen isoform c precursor

    Status: REVIEWED

    Source sequence(s)
    AC005840
  4. NM_001413265.1NP_001400194.1  CD27 antigen isoform d precursor

    Status: REVIEWED

    Source sequence(s)
    AC005840
  5. NM_001413266.1NP_001400195.1  CD27 antigen isoform e

    Status: REVIEWED

    Source sequence(s)
    AC005840, KF570263
  6. NM_001413267.1NP_001400196.1  CD27 antigen isoform e

    Status: REVIEWED

    Source sequence(s)
    AC005840, KF570263
  7. NM_001413268.1NP_001400197.1  CD27 antigen isoform e

    Status: REVIEWED

    Source sequence(s)
    AC005840

RNA

  1. NR_182125.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005840
  2. NR_182126.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005840
  3. NR_182127.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005840
  4. NR_182128.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005840

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    6443892..6451713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020234.2XP_016875723.1  CD27 antigen isoform X1

  2. XM_047429900.1XP_047285856.1  CD27 antigen isoform X2

  3. XM_011521042.4XP_011519344.1  CD27 antigen isoform X3

    Conserved Domains (1) summary
    cl22855
    Location:3478
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    6454276..6462105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373867.1XP_054229842.1  CD27 antigen isoform X4

  2. XM_054373868.1XP_054229843.1  CD27 antigen isoform X5

  3. XM_054373869.1XP_054229844.1  CD27 antigen isoform X3