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KLF4 Kruppel like factor 4 [ Homo sapiens (human) ]

Gene ID: 9314, updated on 15-Apr-2019

Summary

Official Symbol
KLF4provided by HGNC
Official Full Name
Kruppel like factor 4provided by HGNC
Primary source
HGNC:HGNC:6348
See related
Ensembl:ENSG00000136826 MIM:602253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EZF; GKLF
Summary
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Broad expression in colon (RPKM 75.2), esophagus (RPKM 73.6) and 22 other tissues See more
Orthologs

Genomic context

See KLF4 in Genome Data Viewer
Location:
9q31.2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (107484852..107489720, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (110247133..110252047, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1509 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 32 Neighboring gene RNA, U6 small nuclear 492, pseudogene Neighboring gene uncharacterized LOC112268053 Neighboring gene uncharacterized LOC105376206

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4.
NHGRI GWA Catalog
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
NHGRI GWA Catalog
The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 
promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription cofactor binding IEA
Inferred from Electronic Annotation
more info
 
transcription regulatory region DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to cycloheximide IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to laminar fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
cellular response to peptide IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
epidermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
epidermis morphogenesis IEA
Inferred from Electronic Annotation
more info
 
fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
mesodermal cell fate determination TAS
Traceable Author Statement
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration involved in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of chemokine (C-X-C motif) ligand 2 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of heterotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inflammatory response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of interleukin-8 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of leukocyte adhesion to arterial endothelial cell IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of muscle hyperplasia IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cellular protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of core promoter binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of hemoglobin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of telomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
post-embryonic camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
post-embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of axon regeneration IEA
Inferred from Electronic Annotation
more info
 
regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of phosphatidylinositol 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
somatic stem cell population maintenance TAS
Traceable Author Statement
more info
 
stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear euchromatin IEA
Inferred from Electronic Annotation
more info
 
nuclear transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Krueppel-like factor 4
Names
Kruppel-like factor 4 (gut)
endothelial Kruppel-like zinc finger protein
epithelial zinc finger protein EZF
gut Kruppel-like factor
gut-enriched krueppel-like factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001314052.1NP_001300981.1  Krueppel-like factor 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as GKLFa).
    Source sequence(s)
    AF105036, AL360218, BC030811
    UniProtKB/Swiss-Prot
    O43474
    Conserved Domains (4) summary
    COG5048
    Location:425508
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:432454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:430454
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:476501
    zf-H2C2_2; Zinc-finger double domain
  2. NM_004235.6NP_004226.3  Krueppel-like factor 4 isoform 2

    See identical proteins and their annotated locations for NP_004226.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF105036, AL360218, BU739190
    Consensus CDS
    CCDS6770.2
    UniProtKB/Swiss-Prot
    O43474
    Related
    ENSP00000363804.4, ENST00000374672.5
    Conserved Domains (3) summary
    COG5048
    Location:391474
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:398420
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:442467
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    107484852..107489720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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