Format

Send to:

Choose Destination

CDY1 chromodomain Y-linked 1 [ Homo sapiens (human) ]

Gene ID: 9085, updated on 13-Feb-2019

Summary

Official Symbol
CDY1provided by HGNC
Official Full Name
chromodomain Y-linked 1provided by HGNC
Primary source
HGNC:HGNC:1809
See related
Ensembl:ENSG00000172288 MIM:400016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDY; CDY1A
Summary
This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 2.1) See more

Genomic context

See CDY1 in Genome Data Viewer
Location:
Yq11.23
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) Y NC_000024.10 (25622095..25625511)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (27768264..27771049)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene USP9Y pseudogene 33 Neighboring gene chromodomain Y-linked 20 pseudogene Neighboring gene elongin C pseudogene 34 Neighboring gene OFD1 pseudogene 13 Y-linked

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Spermatogenic failure, Y-linked 2
MedGen: C1839071 OMIM: 415000 GeneReviews: Y Chromosome Infertility
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-08-22)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-08-22)

ClinGen Genome Curation Page

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ77185

Gene Ontology Provided by GOA

Function Evidence Code Pubs
histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
histone acetylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
testis-specific chromodomain protein Y 1
Names
chromodomain protein, Y chromosome, 1
chromodomain protein, Y-linked, 1
testis-specific chromodomain protein on Y
NP_004671.1
NP_733841.1
XP_011529814.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_004755.2 

    Range
    3811231..3814016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NG_011754.1 RefSeqGene

    Range
    5001..7786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004680.2NP_004671.1  testis-specific chromodomain protein Y 1 isoform b

    See identical proteins and their annotated locations for NP_004671.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also called the minor variant, lacks a segment in the 3' end of the coding sequence, compared to variant 1. Variant 2 encodes isoform b which has a longer and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AF000981, BC033041
    Consensus CDS
    CCDS14801.1
    UniProtKB/Swiss-Prot
    Q9Y6F8
    Related
    ENSP00000302968.4, ENST00000306609.4
    Conserved Domains (2) summary
    cd06558
    Location:286482
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    smart00298
    Location:558
    CHROMO; Chromatin organization modifier domain
  2. NM_170723.1NP_733841.1  testis-specific chromodomain protein Y 1 isoform a

    See identical proteins and their annotated locations for NP_733841.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also called the major transcript, is unspliced. It encodes isoform a.
    Source sequence(s)
    AF080597, BC033041
    Consensus CDS
    CCDS14802.1
    UniProtKB/Swiss-Prot
    Q9Y6F8
    Related
    ENSP00000354799.2, ENST00000361963.3
    Conserved Domains (2) summary
    cd06558
    Location:286482
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    smart00298
    Location:558
    CHROMO; Chromatin organization modifier domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p12 Primary Assembly

    Range
    25622095..25625511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531512.2XP_011529814.1  testis-specific chromodomain protein Y 1 isoform X1

    See identical proteins and their annotated locations for XP_011529814.1

    Conserved Domains (2) summary
    cd06558
    Location:286464
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    smart00298
    Location:558
    CHROMO; Chromatin organization modifier domain

RNA

  1. XR_938657.2 RNA Sequence

Support Center