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SOCS3 suppressor of cytokine signaling 3 [ Homo sapiens (human) ]

Gene ID: 9021, updated on 30-Apr-2024

Summary

Official Symbol
SOCS3provided by HGNC
Official Full Name
suppressor of cytokine signaling 3provided by HGNC
Primary source
HGNC:HGNC:19391
See related
Ensembl:ENSG00000184557 MIM:604176; AllianceGenome:HGNC:19391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3
Summary
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
Expression
Broad expression in gall bladder (RPKM 130.8), urinary bladder (RPKM 79.6) and 21 other tissues See more
Orthologs
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Genomic context

See SOCS3 in Genome Data Viewer
Location:
17q25.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78356778..78360925, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79250300..79254447, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76352859..76357006, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76311214-76311972 Neighboring gene uncharacterized LOC105371912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12890 Neighboring gene Sharpr-MPRA regulatory region 775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76318420-76318963 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76320051-76320592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76320593-76321136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76321137-76321678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9059 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76338363-76338868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76340895-76341399 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9061 Neighboring gene uncharacterized LOC124904064 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76348009-76348824 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76348825-76349641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76350661-76351162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12891 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:76352361-76352860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76352918-76353567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9063 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:76355514-76356162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76359520-76360097 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76361253-76361828 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76361829-76362406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12892 Neighboring gene SOCS3 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76367859-76368426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76368427-76368994 Neighboring gene RNA, 7SL, cytoplasmic 236, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76374619-76375580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12894 Neighboring gene phosphatidylglycerophosphate synthase 1 Neighboring gene small nucleolar RNA SNORA30/SNORA37 family

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-infected clinical samples upregulate SOCS3 expression in ex vivo cultures of monocyte derived dendritic cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 recruits SOCS-3 through IL-10 activation for suppressing IL-6 and IL-6 dependent STAT3 in immature dentritic cells PubMed
Tat tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of suppressor of cytokine signaling 3 (SOCS3) PubMed
tat HIV-1 Tat upregulates the expression of suppressor of cytokine signaling 3 (SOCS3) in human primary T cells PubMed
tat HIV-1 Tat 47-59 peptide downregulates gene expression of suppressor of cytokine signaling 3 (SOCS3) in U-937 macrophages PubMed
tat HIV-1 Tat-induced SOCS3 expression inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages in a NF-kappaB-dependent manner PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC71791

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables miRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
enables protein tyrosine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in T-helper 17 cell lineage commitment TAS
Traceable Author Statement
more info
PubMed 
involved_in branching involved in labyrinthine layer morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to interleukin-17 IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in placenta blood vessel development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol TAS
Traceable Author Statement
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
suppressor of cytokine signaling 3
Names
STAT-induced STAT inhibitor 3
cytokine-inducible SH2 protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016851.1 RefSeqGene

    Range
    4999..8301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_619

mRNA and Protein(s)

  1. NM_001378932.1NP_001365861.1  suppressor of cytokine signaling 3

    Status: REVIEWED

    Source sequence(s)
    AC061992
    Consensus CDS
    CCDS11756.1
    UniProtKB/Swiss-Prot
    O14509, O14543
    UniProtKB/TrEMBL
    Q5U0H7, Q6FI39
    Conserved Domains (2) summary
    cd10384
    Location:35135
    SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03737
    Location:184225
    SOCS_SOCS3; SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the ...
  2. NM_001378933.1NP_001365862.1  suppressor of cytokine signaling 3

    Status: REVIEWED

    Source sequence(s)
    AC061992
    Consensus CDS
    CCDS11756.1
    UniProtKB/Swiss-Prot
    O14509, O14543
    UniProtKB/TrEMBL
    Q5U0H7, Q6FI39
    Conserved Domains (2) summary
    cd10384
    Location:35135
    SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03737
    Location:184225
    SOCS_SOCS3; SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the ...
  3. NM_003955.5NP_003946.3  suppressor of cytokine signaling 3

    See identical proteins and their annotated locations for NP_003946.3

    Status: REVIEWED

    Source sequence(s)
    AC061992
    Consensus CDS
    CCDS11756.1
    UniProtKB/Swiss-Prot
    O14509, O14543
    UniProtKB/TrEMBL
    Q5U0H7, Q6FI39
    Related
    ENSP00000330341.2, ENST00000330871.3
    Conserved Domains (2) summary
    cd10384
    Location:35135
    SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03737
    Location:184225
    SOCS_SOCS3; SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    78356778..78360925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    79250300..79254447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)