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PER3 period circadian regulator 3 [ Homo sapiens (human) ]

Gene ID: 8863, updated on 2-Nov-2024

Summary

Official Symbol
PER3provided by HGNC
Official Full Name
period circadian regulator 3provided by HGNC
Primary source
HGNC:HGNC:8847
See related
Ensembl:ENSG00000049246 MIM:603427; AllianceGenome:HGNC:8847
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIG13; FASPS3
Summary
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in thyroid (RPKM 14.6), fat (RPKM 11.2) and 24 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See PER3 in Genome Data Viewer
Location:
1p36.23
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (7784291..7845177)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (7315337..7376224)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (7844351..7905237)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene calmodulin binding transcription activator 1 Neighboring gene translation initiation factor IF-2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 185 Neighboring gene MPRA-validated peak40 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7798026-7799225 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:7830560-7831256 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:7831283-7831525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 187 Neighboring gene uncharacterized LOC124903833 Neighboring gene MPRA-validated peak42 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7886590-7887789 Neighboring gene NANOG hESC enhancer GRCh37_chr1:7912645-7913333 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:7929285-7930484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7935645-7936144 Neighboring gene vesicle associated membrane protein 3 Neighboring gene NANOG hESC enhancer GRCh37_chr1:7970949-7971450 Neighboring gene tRNA-undetermined (NNN) 4-1 Neighboring gene urotensin 2 Neighboring gene TNF receptor superfamily member 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Advanced sleep phase syndrome 3
MedGen: C4225169 OMIM: 616882 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of period homolog 3 (Drosophila, PER3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
period circadian protein homolog 3
Names
cell growth-inhibiting gene 13 protein
circadian clock protein PERIOD 3
period circadian clock 3
period circadian protein 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046850.1 RefSeqGene

    Range
    4912..65798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001289861.2NP_001276790.1  period circadian protein homolog 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    Z98884
    Consensus CDS
    CCDS76097.1
    UniProtKB/TrEMBL
    A0A087WV69, A6H8X0
    Related
    ENSP00000479223.1, ENST00000614998.4
    Conserved Domains (3) summary
    cd00130
    Location:285377
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:285373
    PAS_3; PAS fold
    pfam12114
    Location:10641179
    Period_C; Period protein 2/3C-terminal region
  2. NM_001289862.2NP_001276791.1  period circadian protein homolog 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    Z98884
    Consensus CDS
    CCDS72695.1
    UniProtKB/TrEMBL
    A6H8X0
    Related
    ENSP00000482093.1, ENST00000613533.4
    Conserved Domains (3) summary
    cd00130
    Location:285377
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam05109
    Location:7561066
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12114
    Location:10831198
    Period_C; Period protein 2/3C-terminal region
  3. NM_001289863.3NP_001276792.1  period circadian protein homolog 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    Z98884
    UniProtKB/TrEMBL
    A6H8X0
    Conserved Domains (3) summary
    cd00130
    Location:285377
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:285373
    PAS_3; PAS fold
    pfam12114
    Location:10571172
    Period_C; Period protein 2/3C-terminal region
  4. NM_001289864.3NP_001276793.1  period circadian protein homolog 3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    Z98884
    UniProtKB/Swiss-Prot
    P56645
    Conserved Domains (1) summary
    pfam12114
    Location:763878
    Period_C; Period protein 2/3C-terminal region
  5. NM_001377275.1NP_001364204.1  period circadian protein homolog 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    Z98884
    Consensus CDS
    CCDS72695.1
    UniProtKB/TrEMBL
    A6H8X0
    Related
    ENSP00000366755.3, ENST00000377532.8
    Conserved Domains (3) summary
    cd00130
    Location:285377
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam05109
    Location:7561066
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12114
    Location:10831198
    Period_C; Period protein 2/3C-terminal region
  6. NM_001377276.1NP_001364205.1  period circadian protein homolog 3 isoform 6

    Status: REVIEWED

    Source sequence(s)
    Z98884
    UniProtKB/TrEMBL
    A6H8X0
    Conserved Domains (3) summary
    cd00130
    Location:285377
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam05109
    Location:7491058
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam12114
    Location:10751190
    Period_C; Period protein 2/3C-terminal region
  7. NM_016831.4NP_058515.1  period circadian protein homolog 3 isoform 4

    See identical proteins and their annotated locations for NP_058515.1

    Status: REVIEWED

    Source sequence(s)
    Z98884
    Consensus CDS
    CCDS89.1
    UniProtKB/Swiss-Prot
    P56645, Q5H8X4, Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
    UniProtKB/TrEMBL
    A2I2N5, A6H8X0
    Conserved Domains (3) summary
    cd00130
    Location:284376
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam12114
    Location:10731186
    Period_C; Period protein 2/3C-terminal region
    cl25496
    Location:7481057
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    7784291..7845177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433449.1XP_047289405.1  period circadian protein homolog 3 isoform X8

  2. XM_047433435.1XP_047289391.1  period circadian protein homolog 3 isoform X2

  3. XM_047433457.1XP_047289413.1  period circadian protein homolog 3 isoform X12

  4. XM_047433442.1XP_047289398.1  period circadian protein homolog 3 isoform X5

  5. XM_047433459.1XP_047289415.1  period circadian protein homolog 3 isoform X13

  6. XM_047433453.1XP_047289409.1  period circadian protein homolog 3 isoform X10

  7. XM_047433437.1XP_047289393.1  period circadian protein homolog 3 isoform X3

  8. XM_047433440.1XP_047289396.1  period circadian protein homolog 3 isoform X4

  9. XM_047433473.1XP_047289429.1  period circadian protein homolog 3 isoform X15

  10. XM_047433454.1XP_047289410.1  period circadian protein homolog 3 isoform X11

    UniProtKB/Swiss-Prot
    P56645, Q5H8X4, Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
    UniProtKB/TrEMBL
    A2I2N5
    Related
    ENSP00000355031.2, ENST00000361923.2
  11. XM_047433434.1XP_047289390.1  period circadian protein homolog 3 isoform X1

  12. XM_047433446.1XP_047289402.1  period circadian protein homolog 3 isoform X7

  13. XM_047433455.1XP_047289411.1  period circadian protein homolog 3 isoform X11

    UniProtKB/Swiss-Prot
    P56645, Q5H8X4, Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
    UniProtKB/TrEMBL
    A2I2N5
  14. XM_047433436.1XP_047289392.1  period circadian protein homolog 3 isoform X2

  15. XM_047433443.1XP_047289399.1  period circadian protein homolog 3 isoform X5

  16. XM_047433466.1XP_047289422.1  period circadian protein homolog 3 isoform X13

  17. XM_047433447.1XP_047289403.1  period circadian protein homolog 3 isoform X7

  18. XM_047433438.1XP_047289394.1  period circadian protein homolog 3 isoform X3

  19. XM_047433451.1XP_047289407.1  period circadian protein homolog 3 isoform X9

  20. XM_005263524.5XP_005263581.1  period circadian protein homolog 3 isoform X6

    UniProtKB/TrEMBL
    A6H8X0
    Conserved Domains (3) summary
    cd00130
    Location:285377
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:285373
    PAS_3; PAS fold
    pfam12114
    Location:10831192
    Period_C; Period protein 2/3C-terminal region
  21. XM_047433448.1XP_047289404.1  period circadian protein homolog 3 isoform X8

  22. XM_024450586.2XP_024306354.1  period circadian protein homolog 3 isoform X2

    UniProtKB/TrEMBL
    A6H8X0
    Conserved Domains (3) summary
    cd00130
    Location:285377
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam12114
    Location:10811194
    Period_C; Period protein 2/3C-terminal region
    cl25496
    Location:7561065
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  23. XM_047433456.1XP_047289412.1  period circadian protein homolog 3 isoform X12

  24. XM_024450587.2XP_024306355.1  period circadian protein homolog 3 isoform X5

    UniProtKB/TrEMBL
    A6H8X0
    Conserved Domains (3) summary
    cd00130
    Location:285377
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam12114
    Location:10751188
    Period_C; Period protein 2/3C-terminal region
    cl25496
    Location:7491059
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  25. XM_047433458.1XP_047289414.1  period circadian protein homolog 3 isoform X13

  26. XM_017002723.3XP_016858212.1  period circadian protein homolog 3 isoform X3

    UniProtKB/TrEMBL
    A6H8X0
  27. XM_017002724.3XP_016858213.1  period circadian protein homolog 3 isoform X4

    UniProtKB/TrEMBL
    A6H8X0
  28. XM_047433468.1XP_047289424.1  period circadian protein homolog 3 isoform X14

  29. XM_017002726.3XP_016858215.1  period circadian protein homolog 3 isoform X9

    UniProtKB/TrEMBL
    A6H8X0
  30. XM_047433472.1XP_047289428.1  period circadian protein homolog 3 isoform X15

  31. XM_024450590.2XP_024306358.1  period circadian protein homolog 3 isoform X11

    UniProtKB/Swiss-Prot
    P56645, Q5H8X4, Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
    UniProtKB/TrEMBL
    A2I2N5, A6H8X0
    Conserved Domains (3) summary
    cd00130
    Location:284376
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam12114
    Location:10731186
    Period_C; Period protein 2/3C-terminal region
    cl25496
    Location:7481057
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  32. XM_047433439.1XP_047289395.1  period circadian protein homolog 3 isoform X2

  33. XM_047433445.1XP_047289401.1  period circadian protein homolog 3 isoform X6

  34. XM_047433444.1XP_047289400.1  period circadian protein homolog 3 isoform X5

  35. XM_047433441.1XP_047289397.1  period circadian protein homolog 3 isoform X4

  36. XM_047433452.1XP_047289408.1  period circadian protein homolog 3 isoform X9

  37. XM_047433474.1XP_047289430.1  period circadian protein homolog 3 isoform X16

  38. XM_047433475.1XP_047289431.1  period circadian protein homolog 3 isoform X17

  39. XM_017002729.2XP_016858218.2  period circadian protein homolog 3 isoform X18

  40. XM_047433476.1XP_047289432.1  period circadian protein homolog 3 isoform X19

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    7315337..7376224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339423.1XP_054195398.1  period circadian protein homolog 3 isoform X2

  2. XM_054339429.1XP_054195404.1  period circadian protein homolog 3 isoform X5

  3. XM_054339445.1XP_054195420.1  period circadian protein homolog 3 isoform X13

  4. XM_054339434.1XP_054195409.1  period circadian protein homolog 3 isoform X7

  5. XM_054339424.1XP_054195399.1  period circadian protein homolog 3 isoform X3

  6. XM_054339437.1XP_054195412.1  period circadian protein homolog 3 isoform X9

  7. XM_054339432.1XP_054195407.1  period circadian protein homolog 3 isoform X6

  8. XM_054339435.1XP_054195410.1  period circadian protein homolog 3 isoform X8

  9. XM_054339422.1XP_054195397.1  period circadian protein homolog 3 isoform X2

  10. XM_054339443.1XP_054195418.1  period circadian protein homolog 3 isoform X12

  11. XM_054339431.1XP_054195406.1  period circadian protein homolog 3 isoform X5

  12. XM_054339444.1XP_054195419.1  period circadian protein homolog 3 isoform X13

  13. XM_054339425.1XP_054195400.1  period circadian protein homolog 3 isoform X3

  14. XM_054339427.1XP_054195402.1  period circadian protein homolog 3 isoform X4

  15. XM_054339446.1XP_054195421.1  period circadian protein homolog 3 isoform X14

  16. XM_054339436.1XP_054195411.1  period circadian protein homolog 3 isoform X9

  17. XM_054339441.1XP_054195416.1  period circadian protein homolog 3 isoform X11

    UniProtKB/Swiss-Prot
    P56645, Q5H8X4, Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
    UniProtKB/TrEMBL
    A2I2N5
  18. XM_054339439.1XP_054195414.1  period circadian protein homolog 3 isoform X10

  19. XM_054339421.1XP_054195396.1  period circadian protein homolog 3 isoform X1

  20. XM_054339440.1XP_054195415.1  period circadian protein homolog 3 isoform X7

  21. XM_054339442.1XP_054195417.1  period circadian protein homolog 3 isoform X11

    UniProtKB/Swiss-Prot
    P56645, Q5H8X4, Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
    UniProtKB/TrEMBL
    A2I2N5
  22. XM_054339426.1XP_054195401.1  period circadian protein homolog 3 isoform X2

  23. XM_054339447.1XP_054195422.1  period circadian protein homolog 3 isoform X15

  24. XM_054339433.1XP_054195408.1  period circadian protein homolog 3 isoform X6

  25. XM_054339430.1XP_054195405.1  period circadian protein homolog 3 isoform X5

  26. XM_054339428.1XP_054195403.1  period circadian protein homolog 3 isoform X4

  27. XM_054339438.1XP_054195413.1  period circadian protein homolog 3 isoform X9

  28. XM_054339448.1XP_054195423.1  period circadian protein homolog 3 isoform X16

  29. XM_054339449.1XP_054195424.1  period circadian protein homolog 3 isoform X17

  30. XM_054339450.1XP_054195425.1  period circadian protein homolog 3 isoform X18

  31. XM_054339451.1XP_054195426.1  period circadian protein homolog 3 isoform X19