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STX11 syntaxin 11 [ Homo sapiens (human) ]

Gene ID: 8676, updated on 17-Jun-2019

Summary

Official Symbol
STX11provided by HGNC
Official Full Name
syntaxin 11provided by HGNC
Primary source
HGNC:HGNC:11429
See related
Ensembl:ENSG00000135604 MIM:605014
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FHL4; HLH4; HPLH4
Summary
This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 13.4), fat (RPKM 5.2) and 8 other tissues See more
Orthologs

Genomic context

See STX11 in Genome Data Viewer
Location:
6q24.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (144140044..144191939)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (144461770..144513076)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378036 Neighboring gene mitochondrial ribosomal protein L42 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 5218 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane fusion TAS
Traceable Author Statement
more info
PubMed 
synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007613.1 RefSeqGene

    Range
    5001..46423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_113

mRNA and Protein(s)

  1. NM_003764.4NP_003755.2  syntaxin-11

    See identical proteins and their annotated locations for NP_003755.2

    Status: REVIEWED

    Source sequence(s)
    AI791689, AL135917, BC033519, BF941242, BM150302, BQ030324, CR739089
    Consensus CDS
    CCDS5205.1
    UniProtKB/Swiss-Prot
    O75558
    Related
    ENSP00000356540.4, ENST00000367568.4
    Conserved Domains (2) summary
    pfam00804
    Location:41238
    Syntaxin; Syntaxin
    cl22856
    Location:207273
    SNARE; SNARE motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    144140044..144191939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536213.2XP_011534515.1  syntaxin-11 isoform X1

    Conserved Domains (3) summary
    cd00179
    Location:67219
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15878
    Location:229291
    SNARE_syntaxin11; SNARE motif of syntaxin 11
    pfam00804
    Location:67264
    Syntaxin; Syntaxin
  2. XM_011536218.2XP_011534520.1  syntaxin-11 isoform X2

    See identical proteins and their annotated locations for XP_011534520.1

    UniProtKB/Swiss-Prot
    O75558
    Conserved Domains (2) summary
    pfam00804
    Location:41238
    Syntaxin; Syntaxin
    cl22856
    Location:207273
    SNARE; SNARE motif
  3. XM_011536214.2XP_011534516.1  syntaxin-11 isoform X2

    See identical proteins and their annotated locations for XP_011534516.1

    UniProtKB/Swiss-Prot
    O75558
    Conserved Domains (2) summary
    pfam00804
    Location:41238
    Syntaxin; Syntaxin
    cl22856
    Location:207273
    SNARE; SNARE motif
  4. XM_017011400.1XP_016866889.1  syntaxin-11 isoform X2

    UniProtKB/Swiss-Prot
    O75558
    Conserved Domains (2) summary
    pfam00804
    Location:41238
    Syntaxin; Syntaxin
    cl22856
    Location:207273
    SNARE; SNARE motif
  5. XM_011536217.2XP_011534519.1  syntaxin-11 isoform X2

    See identical proteins and their annotated locations for XP_011534519.1

    UniProtKB/Swiss-Prot
    O75558
    Conserved Domains (2) summary
    pfam00804
    Location:41238
    Syntaxin; Syntaxin
    cl22856
    Location:207273
    SNARE; SNARE motif

RNA

  1. XR_001743702.1 RNA Sequence

  2. XR_942613.2 RNA Sequence

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