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CAV1 caveolin 1 [ Homo sapiens (human) ]

Gene ID: 857, updated on 6-May-2021

Summary

Official Symbol
CAV1provided by HGNC
Official Full Name
caveolin 1provided by HGNC
Primary source
HGNC:HGNC:1527
See related
Ensembl:ENSG00000105974 MIM:601047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085
Summary
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
Expression
Biased expression in fat (RPKM 322.1), lung (RPKM 308.8) and 13 other tissues See more
Orthologs
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Try the new Gene table
Try the new Transcript table

Genomic context

See CAV1 in Genome Data Viewer
Location:
7q31.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (116525009..116561185)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116165063..116201239)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986838 Neighboring gene greater CFTR locus negative regulatory element CR2 Neighboring gene caveolin 2 Neighboring gene greater CFTR locus negative regulatory element NR2 Neighboring gene cytosolic oncogenic antisense to MET transcript Neighboring gene greater CFTR locus negative regulatory element CR3 Neighboring gene MET proto-oncogene, receptor tyrosine kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma.
GeneReviews: Not available
Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma.
GeneReviews: Not available
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
GeneReviews: Not available
Genetic determinants of P wave duration and PR segment.
GeneReviews: Not available
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
GeneReviews: Not available
Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations.
GeneReviews: Not available
Genome-wide association study of PR interval.
GeneReviews: Not available
Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.
GeneReviews: Not available
Lipodystrophy, congenital generalized, type 3
MedGen: C2675861 OMIM: 612526 GeneReviews: Not available
Compare labs
Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
GeneReviews: Not available
Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.
GeneReviews: Not available
Partial lipodystrophy, congenital cataracts, and neurodegeneration syndrome
MedGen: C3807567 OMIM: 606721 GeneReviews: Not available
Compare labs
Primary pulmonary hypertension 3 Compare labs
Several common variants modulate heart rate, PR interval and QRS duration.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of caveolin 1 (CAV1) by siRNA enhances HIV-1 infection in human Langerhans cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 forms a stable complex with caveolin-1 through its amino-acid residues 623-631 in HIV-infected cells; antibodies to the caveolin-1 binding domain in gp41 inhibit virus infectivity PubMed
env Amino acid residues 61-101 of caveolin 1 are involved in the binding of caveolin 1 to the N36(L8)C34 domain of gp41 PubMed
Nef nef HIV-1 Nef induces phosphorylation of CAV1 in endothelial cells PubMed
nef HIV-1 Nef redistributes CAV1 during high density lipoprotein stimulation in human aortic endothelial cells (suggesting that HIV interferes with cholesterol efflux by high density lipoproteins) PubMed
nef Cav-1 physically interacts with HIV-1 Nef and restores Nef mediated impairment of apoA-I mediated cholesterol efflux in astrocyte derived glioblastoma cells and macrophages PubMed
Tat tat HIV-1 Tat co-localizes with CAV1 in the cholesterol-enriched lipid rafts of human podocytes PubMed
tat Activation of p38 MAPK in HIV-infected cells mediated by Tat leads to the phosphorylation of p53 which subsequently upregulates CAV-1 expression PubMed
tat Treatment with Tat activates the Ras pathway in human brain micro vascular endothelial cells (HBMECs), an effect that is markedly attenuated by caveolin-1 silencing PubMed
Vpr vpr HIV-1 Vpr C-terminus (residues 52-96) entry into cells is mediated through clathrin- and caveolae/raft-dependent endocytosis PubMed
capsid gag HIV-1 CA co-localizes with langerin and caveolin-1 at the cell membrane of human Langerhans cells PubMed
reverse transcriptase gag-pol CAV-1 expression inhibits HIV-1 replication monitored by reverse transcriptase activity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ATPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cholesterol binding TAS
Traceable Author Statement
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables inward rectifier potassium channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ion channel binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular adaptor activity TAS
Traceable Author Statement
more info
PubMed 
enables nitric-oxide synthase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables patched binding NAS
Non-traceable Author Statement
more info
PubMed 
enables peptidase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell costimulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in angiotensin-activated signaling pathway involved in heart process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in basement membrane organization IEA
Inferred from Electronic Annotation
more info
 
involved_in beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
involved_in calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in caveola assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in caveola assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in caveola assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in caveola assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in caveolin-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hyperoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to peptide hormone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cholesterol homeostasis TAS
Traceable Author Statement
more info
PubMed 
involved_in cholesterol transport TAS
Traceable Author Statement
more info
PubMed 
involved_in inactivation of MAPK activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in insulin receptor internalization IEA
Inferred from Electronic Annotation
more info
 
involved_in lactation IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte migration TAS
Traceable Author Statement
more info
 
involved_in lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in maintenance of protein location in cell ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mammary gland development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mammary gland involution ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in membrane depolarization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of inward rectifier potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of necroptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of peptidyl-tyrosine autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of pinocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of receptor signaling pathway via JAK-STAT ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
involved_in nitric oxide homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ER-associated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of calcium ion transport into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of catalytic activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell adhesion molecule production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gap junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vasoconstriction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in posttranscriptional regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to plasma membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor internalization involved in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor-mediated endocytosis of virus by host cell IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction IC
Inferred by Curator
more info
PubMed 
involved_in regulation of cell communication by electrical coupling involved in cardiac conduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of entry of bacterium into host cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of heart rate by cardiac conduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of membrane repolarization during action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of nitric-oxide synthase activity TAS
Traceable Author Statement
more info
 
involved_in regulation of peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of ruffle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of the force of heart contraction by chemical signal IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ventricular cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within response to estrogen IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to ischemia IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to progesterone IDA
Inferred from Direct Assay
more info
PubMed 
involved_in skeletal muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in triglyceride metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle organization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
part_of caveolar macromolecular signaling complex IEA
Inferred from Electronic Annotation
more info
 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome membrane TAS
Traceable Author Statement
more info
 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion HDA PubMed 
colocalizes_with focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lipid droplet TAS
Traceable Author Statement
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
caveolin-1
Names
caveolin 1, caveolae protein, 22kDa
cell growth-inhibiting protein 32

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012051.1 RefSeqGene

    Range
    5252..41395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172895.1NP_001166366.1  caveolin-1 isoform beta

    See identical proteins and their annotated locations for NP_001166366.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AB209926, AC006159, AK290871, BC006432, BG170208, DB266251
    Consensus CDS
    CCDS55156.1
    UniProtKB/TrEMBL
    A0A024R757, Q2TNI1, Q59E85
    Related
    ENSP00000384348.1, ENST00000405348.6
    Conserved Domains (1) summary
    pfam01146
    Location:14144
    Caveolin
  2. NM_001172896.2NP_001166367.1  caveolin-1 isoform beta

    See identical proteins and their annotated locations for NP_001166367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AB209926, AC006159, AF172085, AK290871, BG170208, DA943080
    Consensus CDS
    CCDS55156.1
    UniProtKB/TrEMBL
    A0A024R757, Q2TNI1, Q59E85, Q7Z4F3
    Related
    ENSP00000377110.1, ENST00000393467.1
    Conserved Domains (1) summary
    pfam01146
    Location:14144
    Caveolin
  3. NM_001172897.2NP_001166368.1  caveolin-1 isoform beta

    See identical proteins and their annotated locations for NP_001166368.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AB209926, AC006159, AK290871, BG170208, DA477166, EF649773
    Consensus CDS
    CCDS55156.1
    UniProtKB/TrEMBL
    A0A024R757, A9XTE5, Q2TNI1, Q59E85
    Related
    ENSP00000377111.1, ENST00000393468.1
    Conserved Domains (1) summary
    pfam01146
    Location:14144
    Caveolin
  4. NM_001753.5NP_001744.2  caveolin-1 isoform alpha

    See identical proteins and their annotated locations for NP_001744.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (alpha).
    Source sequence(s)
    AB209926, AC006159, AK290871, BG170208
    Consensus CDS
    CCDS5767.1
    UniProtKB/Swiss-Prot
    Q03135
    UniProtKB/TrEMBL
    Q2TNI1, Q59E85
    Related
    ENSP00000339191.2, ENST00000341049.7
    Conserved Domains (1) summary
    pfam01146
    Location:45175
    Caveolin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    116525009..116561185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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