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FOXN1 forkhead box N1 [ Homo sapiens (human) ]

Gene ID: 8456, updated on 10-Apr-2019

Summary

Official Symbol
FOXN1provided by HGNC
Official Full Name
forkhead box N1provided by HGNC
Primary source
HGNC:HGNC:12765
See related
Ensembl:ENSG00000109101 MIM:600838
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WHN; RONU; FKHL20
Summary
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 9.7) and esophagus (RPKM 2.5) See more
Orthologs

Genomic context

See FOXN1 in Genome Data Viewer
Location:
17q11.2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (28506211..28538900)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26833249..26865175)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S7 pseudogene 1 Neighboring gene solute carrier family 13 member 2 Neighboring gene unc-119 lipid binding chaperone Neighboring gene phosphatidylinositol glycan anchor biosynthesis class S

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
T cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
hair follicle development IEA
Inferred from Electronic Annotation
more info
 
keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
lymphoid lineage cell migration into thymus IEA
Inferred from Electronic Annotation
more info
 
nail development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of hair follicle development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of positive thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
thymus epithelium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
forkhead box protein N1
Names
Rowett nude
winged-helix nude
winged-helix transcription factor nude

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007260.1 RefSeqGene

    Range
    5001..19217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_61

mRNA and Protein(s)

  1. NM_001369369.1NP_001356298.1  forkhead box protein N1

    Status: REVIEWED

    Source sequence(s)
    AC005726, AI288186, AK313878, Y11739
  2. NM_003593.2NP_003584.2  forkhead box protein N1

    See identical proteins and their annotated locations for NP_003584.2

    Status: REVIEWED

    Source sequence(s)
    Y11739
    Consensus CDS
    CCDS11232.1
    UniProtKB/Swiss-Prot
    O15353
    Related
    ENSP00000226247.2, ENST00000226247.2
    Conserved Domains (1) summary
    pfam00250
    Location:271358
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    28506211..28538900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025228.1XP_016880717.1  forkhead box protein N1 isoform X3

    Conserved Domains (1) summary
    pfam00250
    Location:271358
    Forkhead; Forkhead domain
  2. XM_011525368.2XP_011523670.1  forkhead box protein N1 isoform X7

    See identical proteins and their annotated locations for XP_011523670.1

    Conserved Domains (1) summary
    pfam00250
    Location:59146
    Forkhead; Forkhead domain
  3. XM_011525358.1XP_011523660.1  forkhead box protein N1 isoform X1

    See identical proteins and their annotated locations for XP_011523660.1

    Conserved Domains (1) summary
    pfam00250
    Location:272359
    Forkhead; Forkhead domain
  4. XM_005258046.3XP_005258103.1  forkhead box protein N1 isoform X2

    UniProtKB/Swiss-Prot
    O15353
    Related
    ENSP00000464645.1, ENST00000579795.5
    Conserved Domains (1) summary
    pfam00250
    Location:271358
    Forkhead; Forkhead domain
  5. XM_011525359.1XP_011523661.1  forkhead box protein N1 isoform X1

    See identical proteins and their annotated locations for XP_011523661.1

    Conserved Domains (1) summary
    pfam00250
    Location:272359
    Forkhead; Forkhead domain
  6. XM_017025229.1XP_016880718.1  forkhead box protein N1 isoform X4

  7. XM_017025230.1XP_016880719.1  forkhead box protein N1 isoform X5

  8. XM_017025231.1XP_016880720.1  forkhead box protein N1 isoform X8

  9. XM_011525362.1XP_011523664.1  forkhead box protein N1 isoform X3

    Conserved Domains (1) summary
    pfam00250
    Location:271358
    Forkhead; Forkhead domain
  10. XM_011525369.2XP_011523671.1  forkhead box protein N1 isoform X7

    See identical proteins and their annotated locations for XP_011523671.1

    Conserved Domains (1) summary
    pfam00250
    Location:59146
    Forkhead; Forkhead domain
  11. XM_011525370.2XP_011523672.1  forkhead box protein N1 isoform X7

    See identical proteins and their annotated locations for XP_011523672.1

    Conserved Domains (1) summary
    pfam00250
    Location:59146
    Forkhead; Forkhead domain
  12. XM_011525367.1XP_011523669.1  forkhead box protein N1 isoform X6

    Conserved Domains (1) summary
    pfam00250
    Location:85172
    Forkhead; Forkhead domain
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