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CDCA3 cell division cycle associated 3 [ Homo sapiens (human) ]

Gene ID: 83461, updated on 27-Nov-2024

Summary

Official Symbol
CDCA3provided by HGNC
Official Full Name
cell division cycle associated 3provided by HGNC
Primary source
HGNC:HGNC:14624
See related
Ensembl:ENSG00000111665 MIM:607749; AllianceGenome:HGNC:14624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRCC8; TOME1; TOME-1
Summary
Predicted to be involved in cell division and protein ubiquitination. Located in adherens junction. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 6.4), duodenum (RPKM 3.8) and 20 other tissues See more
Orthologs
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Genomic context

See CDCA3 in Genome Data Viewer
Location:
12p13.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (6844798..6851286, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (6854092..6860585, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6953962..6960450, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6936229-6936797 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:6937955-6938455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6938503-6939038 Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene G protein subunit beta 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5885 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6960952-6961912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4186 Neighboring gene ubiquitin specific peptidase 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6974948-6975610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6975611-6976272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6979885-6980470 Neighboring gene triosephosphate isomerase 1 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC2577

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cell division cycle-associated protein 3
Names
gene-rich cluster protein C8
trigger of mitotic entry protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297602.3NP_001284531.1  cell division cycle-associated protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    U47924
    Consensus CDS
    CCDS76512.1
    UniProtKB/TrEMBL
    B2R749, J3KMY0
    Related
    ENSP00000229265.5, ENST00000229265.10
    Conserved Domains (1) summary
    PHA03247
    Location:2156
    PHA03247; large tegument protein UL36; Provisional
  2. NM_001297603.3NP_001284532.1  cell division cycle-associated protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001284532.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' structure, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (3) has a distinct C-terminus, and is shorter, compared to isoform 1.
    Source sequence(s)
    AK092246, AK291421, U47924
    Consensus CDS
    CCDS76513.1
    UniProtKB/TrEMBL
    F8WDL1
    Related
    ENSP00000415142.2, ENST00000422785.7
  3. NM_001297604.3NP_001284533.1  cell division cycle-associated protein 3 isoform 4

    See identical proteins and their annotated locations for NP_001284533.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (4) has a distinct C-terminus, and is shorter, compared to isoform 1.
    Source sequence(s)
    AK291421, BQ961607, U47924
    Consensus CDS
    CCDS73428.1
    UniProtKB/TrEMBL
    F5GX58
    Related
    ENSP00000441120.1, ENST00000540683.1
  4. NM_001331019.2NP_001317948.1  cell division cycle-associated protein 3 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the both the 5' and 3' coding regions and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus and distict, shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AK291421, AV714087, U47924
    UniProtKB/Swiss-Prot
    Q99618
  5. NM_031299.7NP_112589.1  cell division cycle-associated protein 3 isoform 1

    See identical proteins and their annotated locations for NP_112589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK291421, U47924
    Consensus CDS
    CCDS8565.1
    UniProtKB/Swiss-Prot
    A8K5V6, D3DUS6, Q99618
    UniProtKB/TrEMBL
    B2R749
    Related
    ENSP00000442068.1, ENST00000538862.7

RNA

  1. NR_123727.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK291421, DA735127, U47924
  2. NR_138531.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an exon in the 5' region and uses an alternate splice site in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 6, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    U47924

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    6844798..6851286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429628.1XP_047285584.1  cell division cycle-associated protein 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    6854092..6860585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373379.1XP_054229354.1  cell division cycle-associated protein 3 isoform X1