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CAPZA1 capping actin protein of muscle Z-line subunit alpha 1 [ Homo sapiens (human) ]

Gene ID: 829, updated on 21-Apr-2019

Summary

Official Symbol
CAPZA1provided by HGNC
Official Full Name
capping actin protein of muscle Z-line subunit alpha 1provided by HGNC
Primary source
HGNC:HGNC:1488
See related
Ensembl:ENSG00000116489 MIM:601580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAPZ; CAZ1; CAPPA1
Summary
CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 69.5), appendix (RPKM 61.9) and 25 other tissues See more
Orthologs

Genomic context

See CAPZA1 in Genome Data Viewer
Location:
1p13.2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (112619453..112671619)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113162075..113214241)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 4256 Neighboring gene Wnt family member 2B Neighboring gene suppression of tumorigenicity 7 like Neighboring gene mitochondrial ribosomal protein L53 pseudogene 1 Neighboring gene RNA, U7 small nuclear 70 pseudogene Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene ras homolog family member C Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1J

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of capping protein (actin filament) muscle Z-line, alpha 1 (CAPZA1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Advanced glycosylation endproduct receptor signaling, organism-specific biosystem (from REACTOME)
    Advanced glycosylation endproduct receptor signaling, organism-specific biosystemAdvanced Glycosylation End- product-specific Receptor (AGER) also known as Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand membrane receptor belonging to the immunoglobulin supe...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding TAS
Traceable Author Statement
more info
PubMed 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
cell junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
WASH complex IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
F-actin-capping protein subunit alpha-1
Names
Cap Z
capZ alpha-1
capping actin protein of muscle Z-line alpha subunit 1
capping protein (actin filament) muscle Z-line, alpha 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006135.3NP_006126.1  F-actin-capping protein subunit alpha-1

    See identical proteins and their annotated locations for NP_006126.1

    Status: REVIEWED

    Source sequence(s)
    BC000144
    Consensus CDS
    CCDS30805.1
    UniProtKB/Swiss-Prot
    P52907
    UniProtKB/TrEMBL
    A0A024R0E5
    Related
    ENSP00000263168.3, ENST00000263168.4
    Conserved Domains (1) summary
    pfam01267
    Location:14282
    F-actin_cap_A; F-actin capping protein alpha subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    112619453..112671619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002424.2XP_016857913.1  F-actin-capping protein subunit alpha-1 isoform X1

  2. XM_011542225.3XP_011540527.1  F-actin-capping protein subunit alpha-1 isoform X2

    Conserved Domains (1) summary
    pfam01267
    Location:14195
    F-actin_cap_A; F-actin capping protein alpha subunit
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