Format

Send to:

Choose Destination

MADCAM1 mucosal vascular addressin cell adhesion molecule 1 [ Homo sapiens (human) ]

Gene ID: 8174, updated on 15-Apr-2019

Summary

Official Symbol
MADCAM1provided by HGNC
Official Full Name
mucosal vascular addressin cell adhesion molecule 1provided by HGNC
Primary source
HGNC:HGNC:6765
See related
Ensembl:ENSG00000099866 MIM:102670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MACAM1
Summary
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in appendix (RPKM 6.2), spleen (RPKM 4.9) and 6 other tissues See more
Orthologs

Genomic context

See MADCAM1 in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (496490..505343)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (496487..505343)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SHC adaptor protein 2 Neighboring gene RNA, 5S ribosomal pseudogene 462 Neighboring gene outer dense fiber of sperm tails 3 like 2 Neighboring gene uncharacterized LOC105372232 Neighboring gene tubulin polyglutamylase complex subunit 1 Neighboring gene cell division cycle 34

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
  • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
    Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
  • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
    Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
    Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem (from Pathway Interaction Database)
    Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem
    Paxillin-independent events mediated by a4b1 and a4b7

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
integrin binding involved in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin binding involved in cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
heterotypic cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte tethering or rolling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukocyte tethering or rolling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of leukocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of lymphocyte migration IEA
Inferred from Electronic Annotation
more info
 
receptor clustering IDA
Inferred from Direct Assay
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
mucosal addressin cell adhesion molecule 1
Names
MAdCAM-1
hMAdCAM-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130760.3NP_570116.2  mucosal addressin cell adhesion molecule 1 isoform a precursor

    See identical proteins and their annotated locations for NP_570116.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer, predominant transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC005775, DB323303, U43628, U82483
    Consensus CDS
    CCDS12028.1
    UniProtKB/Swiss-Prot
    Q13477
    Related
    ENSP00000215637.2, ENST00000215637.8
    Conserved Domains (4) summary
    smart00410
    Location:33111
    IG_like; Immunoglobulin like
    pfam09085
    Location:113221
    Adhes-Ig_like; Adhesion molecule, immunoglobulin-like
    pfam12238
    Location:228290
    MSA-2c; Merozoite surface antigen 2c
    cl11960
    Location:26109
    Ig; Immunoglobulin domain
  2. NM_130762.2NP_570118.1  mucosal addressin cell adhesion molecule 1 isoform b precursor

    See identical proteins and their annotated locations for NP_570118.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) that lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AY732484, U82483
    Consensus CDS
    CCDS12029.1
    UniProtKB/Swiss-Prot
    Q13477
    Related
    ENSP00000304247.2, ENST00000346144.8
    Conserved Domains (3) summary
    smart00410
    Location:33111
    IG_like; Immunoglobulin like
    pfam09085
    Location:113221
    Adhes-Ig_like; Adhesion molecule, immunoglobulin-like
    cl11960
    Location:28109
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    496490..505343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center