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DCSTAMP dendrocyte expressed seven transmembrane protein [ Homo sapiens (human) ]

Gene ID: 81501, updated on 13-Feb-2019

Summary

Official Symbol
DCSTAMPprovided by HGNC
Official Full Name
dendrocyte expressed seven transmembrane proteinprovided by HGNC
Primary source
HGNC:HGNC:18549
See related
Ensembl:ENSG00000164935 MIM:605933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIND; TM7SF4; hDC-STAMP
Summary
This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Expression
Biased expression in lung (RPKM 1.3), liver (RPKM 0.2) and 4 other tissues See more
Orthologs

Genomic context

See DCSTAMP in Genome Data Viewer
Location:
8q22.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (104339087..104356874)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (105352024..105368917)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene regulating synaptic membrane exocytosis 2 Neighboring gene uncharacterized LOC105375688 Neighboring gene uncharacterized LOC107986899 Neighboring gene uncharacterized LOC105375692 Neighboring gene uncharacterized LOC105375691 Neighboring gene dihydropyrimidinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138223, MGC138225, MGC177336

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to macrophage colony-stimulating factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to tumor necrosis factor ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
myeloid dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
osteoclast fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of bone resorption ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of macrophage fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of monocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dendritic cell-specific transmembrane protein
Names
DC-specific transmembrane protein
Dendritic cells (DC)-specific transmembrane protein
IL-4-induced protein
IL-Four (IL-4) induced
IL-Four INDuced
IL-four-induced protein
transmembrane 7 superfamily member 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257317.1NP_001244246.1  dendritic cell-specific transmembrane protein isoform 2

    See identical proteins and their annotated locations for NP_001244246.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region and uses an alternate splice site which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF277290, AP003471, BC171732, DA154308
    Consensus CDS
    CCDS59111.1
    UniProtKB/Swiss-Prot
    Q9H295
    Related
    ENSP00000480546.1, ENST00000622554.1
    Conserved Domains (1) summary
    pfam07782
    Location:242278
    DC_STAMP; DC-STAMP-like protein
  2. NM_030788.4NP_110415.1  dendritic cell-specific transmembrane protein isoform 1

    See identical proteins and their annotated locations for NP_110415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF277290, AP003471, BC069349
    Consensus CDS
    CCDS6301.1
    UniProtKB/Swiss-Prot
    Q9H295
    Related
    ENSP00000297581.2, ENST00000297581.2
    Conserved Domains (1) summary
    pfam07782
    Location:242421
    DC_STAMP; DC-STAMP-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    104339087..104356874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517321.1XP_011515623.1  dendritic cell-specific transmembrane protein isoform X1

    See identical proteins and their annotated locations for XP_011515623.1

    UniProtKB/Swiss-Prot
    Q9H295
    Conserved Domains (1) summary
    pfam07782
    Location:242421
    DC_STAMP; DC-STAMP-like protein
  2. XM_011517324.1XP_011515626.1  dendritic cell-specific transmembrane protein isoform X3

    See identical proteins and their annotated locations for XP_011515626.1

    UniProtKB/Swiss-Prot
    Q9H295
    Conserved Domains (1) summary
    pfam07782
    Location:242278
    DC_STAMP; DC-STAMP-like protein
  3. XM_024447289.1XP_024303057.1  dendritic cell-specific transmembrane protein isoform X2

    Conserved Domains (1) summary
    pfam07782
    Location:242356
    DC_STAMP; DC-STAMP-like protein
  4. XM_024447288.1XP_024303056.1  dendritic cell-specific transmembrane protein isoform X1

    Conserved Domains (1) summary
    pfam07782
    Location:242421
    DC_STAMP; DC-STAMP-like protein
  5. XM_024447290.1XP_024303058.1  dendritic cell-specific transmembrane protein isoform X3

    Conserved Domains (1) summary
    pfam07782
    Location:242278
    DC_STAMP; DC-STAMP-like protein
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