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GRIP2 glutamate receptor interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 80852, updated on 21-Apr-2019

Summary

Official Symbol
GRIP2provided by HGNC
Official Full Name
glutamate receptor interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:23841
See related
Ensembl:ENSG00000144596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in heart (RPKM 7.1), spleen (RPKM 5.7) and 21 other tissues See more
Orthologs

Genomic context

See GRIP2 in Genome Data Viewer
Location:
3p25.1
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (14485105..14602996, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (14530396..14583588, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1267 Neighboring gene uncharacterized LOC105376959 Neighboring gene RNA, 5S ribosomal pseudogene 124 Neighboring gene solute carrier family 6 member 6 Neighboring gene RNA, U6 small nuclear 905, pseudogene Neighboring gene RHBDF1 pseudogene 1 Neighboring gene uncharacterized LOC105376960 Neighboring gene coiled-coil domain containing 174 Neighboring gene chromosome 3 open reading frame 20

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
receptor signaling complex scaffold activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
artery smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter receptor transport, endosome to postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport in synapse IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutamate receptor-interacting protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080423.4NP_001073892.3  glutamate receptor-interacting protein 2

    See identical proteins and their annotated locations for NP_001073892.3

    Status: VALIDATED

    Source sequence(s)
    AB051506, AC090952, AK024507, AK095762
    Consensus CDS
    CCDS46766.2
    UniProtKB/Swiss-Prot
    Q9C0E4
    UniProtKB/TrEMBL
    A0A087WU38
    Related
    ENSP00000478352.1, ENST00000621039.5
    Conserved Domains (1) summary
    cd00992
    Location:655735
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    14485105..14602996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534142.3XP_011532444.1  glutamate receptor-interacting protein 2 isoform X2

    Conserved Domains (1) summary
    cd00992
    Location:660740
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. XM_011534143.3XP_011532445.1  glutamate receptor-interacting protein 2 isoform X3

    Conserved Domains (1) summary
    cd00992
    Location:620700
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. XM_011534141.3XP_011532443.1  glutamate receptor-interacting protein 2 isoform X1

    Conserved Domains (1) summary
    cd00992
    Location:662742
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  4. XM_011534146.3XP_011532448.1  glutamate receptor-interacting protein 2 isoform X5

    Conserved Domains (1) summary
    cd00992
    Location:408488
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. XM_011534145.3XP_011532447.1  glutamate receptor-interacting protein 2 isoform X4

    Conserved Domains (1) summary
    cd00992
    Location:434514
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RNA

  1. XR_940504.3 RNA Sequence

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