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PDCD1LG2 programmed cell death 1 ligand 2 [ Homo sapiens (human) ]

Gene ID: 80380, updated on 21-Apr-2019

Summary

Official Symbol
PDCD1LG2provided by HGNC
Official Full Name
programmed cell death 1 ligand 2provided by HGNC
Primary source
HGNC:HGNC:18731
See related
Ensembl:ENSG00000197646 MIM:605723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2
Expression
Broad expression in spleen (RPKM 7.3), lymph node (RPKM 5.3) and 21 other tissues See more
Orthologs

Genomic context

See PDCD1LG2 in Genome Data Viewer
Location:
9p24.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (5510438..5571282)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (5510512..5571282)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene plasminogen receptor with a C-terminal lysine Neighboring gene ring finger protein 152 pseudogene 1 Neighboring gene CD274 molecule Neighboring gene RIC1 homolog, RAB6A GEF complex partner 1 Neighboring gene endoplasmic reticulum metallopeptidase 1 Neighboring gene Sharpr-MPRA regulatory region 2314

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
    Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • PD-1 signaling, organism-specific biosystem (from REACTOME)
    PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142238, MGC142240

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell costimulation TAS
Traceable Author Statement
more info
 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
programmed cell death 1 ligand 2
Names
B7 dendritic cell molecule
B7-DC
PD-1-ligand 2
PDCD1 ligand 2
butyrophilin B7-DC
programmed death ligand 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025239.3NP_079515.2  programmed cell death 1 ligand 2 precursor

    See identical proteins and their annotated locations for NP_079515.2

    Status: VALIDATED

    Source sequence(s)
    AF329193, AF344424, AK001872, BX951459, CA442083
    Consensus CDS
    CCDS6465.1
    UniProtKB/Swiss-Prot
    Q9BQ51
    Related
    ENSP00000380855.3, ENST00000397747.4
    Conserved Domains (2) summary
    smart00410
    Location:35119
    IG_like; Immunoglobulin like
    cl11960
    Location:137193
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    5510438..5571282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251600.3XP_005251657.1  programmed cell death 1 ligand 2 isoform X1

    Conserved Domains (2) summary
    smart00410
    Location:35119
    IG_like; Immunoglobulin like
    cl11960
    Location:137193
    Ig; Immunoglobulin domain
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