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PSCA prostate stem cell antigen [ Homo sapiens (human) ]

Gene ID: 8000, updated on 10-Dec-2024

Summary

Official Symbol
PSCAprovided by HGNC
Official Full Name
prostate stem cell antigenprovided by HGNC
Primary source
HGNC:HGNC:9500
See related
Ensembl:ENSG00000167653 MIM:602470; AllianceGenome:HGNC:9500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRO232; lncPSCA
Summary
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Expression
Biased expression in stomach (RPKM 721.2), urinary bladder (RPKM 108.9) and 1 other tissue See more
Orthologs
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Genomic context

See PSCA in Genome Data Viewer
Location:
8q24.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (142670297..142682725)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (143813825..143826193)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143751715..143764143)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928087 Neighboring gene Jrk helix-turn-helix protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143743050-143743570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143743571-143744089 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143748299-143749154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143762658-143763304 Neighboring gene uncharacterized LOC124902032 Neighboring gene lncRNA associated with ovarian cancer 1 Neighboring gene lymphocyte antigen 6 family member K

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.
EBI GWAS Catalog
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
EBI GWAS Catalog
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acetylcholine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acetylcholine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables acetylcholine receptor regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011722.3 RefSeqGene

    Range
    15188..17418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005672.5NP_005663.2  prostate stem cell antigen preproprotein

    See identical proteins and their annotated locations for NP_005663.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the functional protein.
    Source sequence(s)
    AI685668, BC048808, CB993163
    Consensus CDS
    CCDS47925.2
    UniProtKB/Swiss-Prot
    O43653, Q6UW92
    Related
    ENSP00000301258.4, ENST00000301258.5
    Conserved Domains (1) summary
    pfam00021
    Location:1484
    UPAR_LY6; u-PAR/Ly-6 domain

RNA

  1. NR_033343.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in its 5'-most exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame coding region, compared to variant 1.
    Source sequence(s)
    AC108002, AI685668, BC048808, BI758811, BU157227

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    142670297..142682725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    143813825..143826193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)