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CALCR calcitonin receptor [ Homo sapiens (human) ]

Gene ID: 799, updated on 3-Mar-2019

Summary

Official Symbol
CALCRprovided by HGNC
Official Full Name
calcitonin receptorprovided by HGNC
Primary source
HGNC:HGNC:1440
See related
Ensembl:ENSG00000004948 MIM:114131
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRT; CTR; CT-R; CTR1
Summary
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See CALCR in Genome Data Viewer
Location:
7q21.3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (93424487..93574730, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (93053799..93204042, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene HEPACAM family member 2 Neighboring gene VPS50 subunit of EARP/GARPII complex Neighboring gene microRNA 653 Neighboring gene microRNA 489 Neighboring gene uncharacterized LOC105375400 Neighboring gene ribosomal protein S27 pseudogene 17 Neighboring gene microRNA 4652

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Postmenopausal osteoporosis
MedGen: C0029458 OMIM: 166710 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat and RANKL/M-CSF enhance osteoclast differentiation and activity by increasing osteoclast differentiation markers, such as cathepsin K and calcitonin receptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Calcitonin-like ligand receptors, organism-specific biosystem (from REACTOME)
    Calcitonin-like ligand receptors, organism-specific biosystemThe calcitonin peptide family comprises calcitonin, amylin, calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and intermedin (AM2). Calcitonin is a 32 amino acid peptide, involved in bone h...
  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway, organism-specific biosystem (from WikiPathways)
    RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway, organism-specific biosystemRANKL (Receptor activator of nuclear factor-kappa B ligand), RANK (Receptor activator of nuclear factor-kappa B) and the natural decoy receptor of RANKL, OPG (Osteoprotegerin) are three important mol...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to amylin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to amylin receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
amylin receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
amyloid-beta binding IC
Inferred by Curator
more info
PubMed 
calcitonin binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT calcitonin binding IDA
Inferred from Direct Assay
more info
PubMed 
calcitonin binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcitonin gene-related peptide receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
calcitonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
NOT activation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
amylin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
amylin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cross-receptor inhibition within G protein-coupled receptor heterodimer IPI
Inferred from Physical Interaction
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of calcium ion import across plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein kinase A signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
response to glucocorticoid IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
amylin receptor complex 1 IDA
Inferred from Direct Assay
more info
PubMed 
amylin receptor complex 2 IDA
Inferred from Direct Assay
more info
PubMed 
amylin receptor complex 3 IDA
Inferred from Direct Assay
more info
PubMed 
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013005.1 RefSeqGene

    Range
    5001..155244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164737.2NP_001158209.2  calcitonin receptor isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC003078, AK313996, L00587
    Consensus CDS
    CCDS55125.1
    Related
    ENSP00000352561.2, ENST00000359558.6
    Conserved Domains (2) summary
    pfam02793
    Location:69137
    HRM; Hormone receptor domain
    cd15274
    Location:145424
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
  2. NM_001164738.1NP_001158210.1  calcitonin receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001158210.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AB022178, AC003078
    Consensus CDS
    CCDS5631.1
    UniProtKB/Swiss-Prot
    P30988
    UniProtKB/TrEMBL
    A0A0C4DG16
    Related
    ENSP00000377959.1, ENST00000394441.5
    Conserved Domains (2) summary
    pfam00002
    Location:145387
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:69137
    HRM; Hormone receptor domain
  3. NM_001742.3NP_001733.1  calcitonin receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001733.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC003078, AC005024, AK313996
    Consensus CDS
    CCDS5631.1
    UniProtKB/Swiss-Prot
    P30988
    UniProtKB/TrEMBL
    A0A0C4DG16
    Related
    ENSP00000389295.1, ENST00000426151.6
    Conserved Domains (2) summary
    pfam00002
    Location:145387
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:69137
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    93424487..93574730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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