RPP21 ribonuclease P subunit p21 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPP21provided by HGNC
Official Full Name: ribonuclease P subunit p21provided by HGNC
Primary source: HGNC:HGNC:21300
See related: Ensembl:ENSG00000241370 MIM:612524; AllianceGenome:HGNC:21300
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAT60; C6orf135
Summary: RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]
Expression: Ubiquitous expression in endometrium (RPKM 10.7), ovary (RPKM 10.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p22.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (30345156..30346857)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (30209367..30211068)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (30312933..30314634)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results demonstrate that Rpp29 and Rpp21 depletion impairs double-strand break (DSB) repair by homology-directed repair (HDR), but has no deleterious effect on the integrity of non-homologous end joining. Rpp29 and Rpp21 are rapidly and transiently recruited to laser-microirradiated sites. They bind poly ADP-ribose moieties and are recruited to DNA damage sites in a PARP1-dependent manner.
Title: A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks.
Observational study of gene-disease association. (HuGE Navigator)
Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Readthrough TRIM39-RPP21

Readthrough gene: TRIM39-RPP21, Included gene: TRIM39

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonuclease P RNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to ribonuclease P activity	IDA Inferred from Direct Assay more info	PubMed
enables ribonuclease P activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in tRNA 5'-leader removal	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of endoribonuclease complex	IEA Inferred from Electronic Annotation more info
part_of multimeric ribonuclease P complex	IDA Inferred from Direct Assay more info	PubMed
part_of nucleolar ribonuclease P complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribonuclease P protein subunit p21

Names: RNaseP protein p21; ribonuclease P/MRP 21kDa subunit; ribonuclease P/MRP subunit p21; ribonucleoprotein V

NP_001186049.1

EC 3.1.26.5

NP_001186050.1

EC 3.1.26.5

NP_079115.1

EC 3.1.26.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199120.3 → NP_001186049.1 ribonuclease P protein subunit p21 isoform 1

See identical proteins and their annotated locations for NP_001186049.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AJ504713, BG708140, BI598757, DA270919

Consensus CDS

CCDS56409.1

UniProtKB/TrEMBL

A0A0G2JIT5, A0A140T9R9, A0A1U9X8H1, A0A1U9X8H3

Related

ENSP00000409799.2, ENST00000433076.6

Conserved Domains (1) summary

pfam04032
Location:13 → 103

Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain
NM_001199121.3 → NP_001186050.1 ribonuclease P protein subunit p21 isoform 3

See identical proteins and their annotated locations for NP_001186050.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, and an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AJ504716, BG708140, DA270919

Consensus CDS

CCDS56410.1

UniProtKB/TrEMBL

A0A0G2JJY3

Related

ENSP00000397778.2, ENST00000436442.2

Conserved Domains (1) summary

pfam04032
Location:13 → 96

Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain
NM_024839.4 → NP_079115.1 ribonuclease P protein subunit p21 isoform 2

See identical proteins and their annotated locations for NP_079115.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AJ504713, BG708140, DA270919

Consensus CDS

CCDS4679.1

UniProtKB/Swiss-Prot

A2AAZ8, B0S834, B0S835, Q5JPL9, Q5JPM1, Q5STF8, Q5STF9, Q5STG2, Q5SU41, Q5SU42, Q86Y49, Q86Y50, Q86Y51, Q96F16, Q9H633

UniProtKB/TrEMBL

A0A0G2JJ26

Related

ENSP00000403833.2, ENST00000442966.7

Conserved Domains (1) summary

pfam04032
Location:13 → 96

Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain